# NATURIUM Multi-Peptide Advanced Serum for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [NATURIUM](https://lovi.care/skincare/brands/naturium)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your combination skin as Ferulic Acid and Glycerin provide antioxidant activity and humectant action, but it lacks sufficient ingredients for optimal oil control on your oily areas.
- The serum provides general skincare benefits, such as hydration and soothing, for acne and blemishes due to the presence of Glycerin and Squalane.
- The product is safe for your combination skin with no risks of irritation due to the absence of harsh ingredients and the presence of soothing ingredients like sunflower extract and rosemary leaf extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/naturium/multi-peptide-advanced-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/naturium/multi-peptide-advanced-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/naturium/multi-peptide-advanced-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/p/naturium/multi-peptide-advanced-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/naturium/multi-peptide-advanced-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/naturium/multi-peptide-advanced-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/naturium/multi-peptide-advanced-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Multi-Peptide Blend, Ferulic Acid, Hydrolyzed Collagen, Squalane, Acetyl Hexapeptide-8

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A topical antioxidant solution of 15% L-ascorbic acid, 1% alpha-tocopherol, and 0.5% ferulic acid provides significant photoprotection against solar-simulated UV radiation in human skin compared to its vehicle. ([Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/))
- A topical serum with a peptide blend showed superior or comparable skin recovery to a moisturizer following fractional CO2 laser and radiofrequency microneedling in Asian subjects. ([Dermatology and Therapy, 2026](https://pubmed.ncbi.nlm.nih.gov/42322532/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))
- Combining fractional microneedle radiofrequency with a topical antioxidant serum significantly reduced wrinkle severity by 29.9% versus 18.0%, increased elasticity by 12.9% versus 2.3%, and improved aesthetic outcomes in 31 participants compared to radiofrequency and placebo. ([The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/40464749/))
- Pretreatment with a topical antioxidant mixture of vitamin C, ferulic acid, and phloretin attenuated ultraviolet-induced sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, p53 protein expression, and the suppression of CD1a-expressing Langerhans cells in human skin compared to vehicle control. ([Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))

## Why other serums fit acne-prone skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/))

## What reviewers say

Users with dry, mature, and sensitive skin frequently praise this serum for its ability to visibly plump fine lines and deliver a "glass-skin" radiance without irritation. Many report smoother texture and improved hydration, while a minority of users experienced breakouts or frustration with the packaging design.

- Liked: Elegant texture (often mentioned)
- Liked: Hydrating and plumping (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Great value (sometimes noted)
- Liked: Visible anti-aging (sometimes noted)
- Disliked: Poor pump design (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Runs out quickly (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Naturium Multi-Peptide work for acne-prone skin?

Naturium Multi-Peptide Advanced Serum works moderately well for acne-prone skin, providing helpful hydration and soothing benefits while lacking sufficient oil control for oily areas. To fit this skin better, a product needs effective ingredients like niacinamide and zinc PCA to control oiliness while keeping the skin balanced and clear.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for acne-prone skin?

Glycerin and squalane make this serum work for your skin because they provide hydration and soothing benefits for blemishes. However, products that fit this skin best need ingredients like niacinamide, zinc PCA, and propolis to properly control oil.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What do Peptides do for acne-prone skin?

Peptides help acne-prone skin by fighting acne-causing bacteria and calming redness and swelling. They may also support the skin barrier, which is often delicate when you deal with breakouts.
Sources: [Biochemical Pharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/39662606/), [Antibiotics, 2020](https://pubmed.ncbi.nlm.nih.gov/31940992/)

### What does Ferulic Acid do for acne-prone skin?

Ferulic acid helps protect acne-prone skin from UV damage and may reduce redness and dark spots left behind after breakouts clear. Combining it with supportive treatments can also improve skin texture and tone while helping calm inflammation.
Sources: [Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/), [Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum fits into an evening routine for acne-prone skin, though a product of this type needs more oil-controlling ingredients to be a great fit for this skin.

### Can I use it with retinol, and in what order?

You can use this serum in the evening after your cleanser and toner, applying it before your moisturizer and letting it absorb before using retinol. It is unlikely to cause irritation due to its soothing ingredients, though acne-prone skin needs extra oil-controlling ingredients for an optimal fit.

### How often should I use this serum?

This serum fits your acne-prone skin on average, working well for hydration while lacking strong oil control. You can use it in the evening as part of your routine. Acne-prone skin needs products with oil-absorbing minerals, salicylic acid, or niacinamide to help manage oil and keep pores clear.

### Can it clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to cause breakouts for your acne-prone skin because it contains soothing ingredients and lacks harsh components, though some reviewers have reported minor breakouts. This type of skin needs lightweight, balancing formulas with ingredients that help control oil and keep pores clear.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — $28.88 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — $39.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — $15.60 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — $15.50 at Amazon

## Where to buy

- Amazon.com: $24.88 (https://www.amazon.com/dp/B0CQTSM65J?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Propanediol, Caprylic Capric Triglyceride, Isopentyldiol, Ethylhexyl Polyhydroxystearate, Squalane, Tetradecane, Glyceryl Stearate Citrate, Butyrospermum Parkii Butter Shea Butter, Polyglyceryl-3 Stearate, Helianthus Annuus Extract Sunflower Extract, Rice Bran Extract, Mannitol, Phosphatidylcholine, Ferulic Acid, Arginine, Acetyl Hexapeptide-8, Copper Palmitoyl Heptapeptide-14, Palmitoyl Sh-Hexapeptide-13 Serine Sp Amide, Hydrolyzed Collagen, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Lactic Acid Glycolic Acid Copolymer, Glycerin, Tocopherol, Pullulan, Lysolecithin, Sclerotium Gum, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Dimethicone, Sodium Phytate, Diglycerin, Hydrogenated Lecithin, Silica, Cetyl Alcohol, Hydroxyacetophenone, Polysorbate 60, Sorbitan Isostearate, Sodium Hydroxide, Sodium Benzoate, Potassium Sorbate, Polyvinyl Alcohol, Decyl Glucoside, Xanthan Gum, Tocopheryl Acetate, Sodium Chloride, Citric Acid, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin