# Natura Bissé C+C Vitamin Complex for sensitive skin

**Lovi Fit: Low fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Natura Bissé](https://lovi.care/skincare/brands/natura-bisse)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A weak match for sensitive skin; the serums alongside fit it better.

## Why this fit

- Offers moderate skin brightening for your normal skin due to Sodium Ascorbyl Phosphate and Tocopheryl Acetate, which provide antioxidant activity and support barrier repair. While these ingredients offer general skincare benefits, they are not specifically targeted to address your redness and irritation.
- The formula is generally safe for your sensitive skin as it lacks harsh or prohibited ingredients, ensuring no risks of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/natura-bisse/c-c-vitamin-complex/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/p/natura-bisse/c-c-vitamin-complex/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/natura-bisse/c-c-vitamin-complex/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin): Low (this page)
- [Acne-prone skin](https://lovi.care/skincare/p/natura-bisse/c-c-vitamin-complex/for/acne-prone-skin): Low
- [Skin with dark spots](https://lovi.care/skincare/p/natura-bisse/c-c-vitamin-complex/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/natura-bisse/c-c-vitamin-complex/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/natura-bisse/c-c-vitamin-complex/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin): Low

## Key ingredients

Ascorbic Acid, Vitamin E, Rosa Canina Oil Fruit, Hydrolyzed Collagen, Tocopherol

## What the research says

- Co-encapsulation of alpha-tocopherol and alpha-tocopheryl acetate in nanostructured lipid carrier gel formulations significantly enhanced moisture retention up to 68% and improved skin elasticity in human volunteers compared to a solution gel. ([Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41309687/))
- Transdermal emulgel preparations containing 5% ascorbic acid and sodium ascorbyl phosphate both effectively reduced wrinkle depth and enhanced skin elasticity in human volunteers with no statistically significant difference between them. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32383548/))
- Vitamin E in O/W and W/O emulsions significantly increased stratum corneum hydration and enhanced water-binding capacity, with an optimum concentration of 5%. ([Arzneimittel-Forschung, 1998](https://pubmed.ncbi.nlm.nih.gov/9706379/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/))
- Topical treatments containing rosehip extract may reduce the size and erythema of postsurgical scars through macrophage polarization and inflammatory cytokine inhibition, though current clinical evidence remains insufficient to recommend its routine use. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37605366/))
- Sunflower and rosehip oil nanoemulsions prepared with a mix of phospholipids and synthetic emulsifiers permeated intact skin to the dermis and showed a more prominent healing effect in a human organotypic skin explant culture wound model compared to nanoemulsions prepared only with phospholipids. ([Pharmaceutics, 2023](https://pubmed.ncbi.nlm.nih.gov/36986857/))
- A nanoemulsion containing 1 mg/mL kojic dipalmitate and 5% rosehip oil demonstrated high incorporation efficiency, suitable physicochemical stability, antioxidant and depigmenting efficacy close to 1 mM ascorbic acid, and no cytotoxicity at concentrations from 0.06% to 1% in vitro. ([Pharmaceutics, 2023](https://pubmed.ncbi.nlm.nih.gov/36839792/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))

## Why other serums fit sensitive skin better

- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))

## What reviewers say

Based on limited data, users consistently praise this serum for its potent brightening abilities, noting that it effectively revitalizes dull, tired-looking skin and improves overall radiance. The lightweight, fast-absorbing texture is a hit, though some users with sensitive skin caution against potential irritation due to the high concentration of Vitamin C and strong citrus fragrance.

- Liked: Brightens dull skin (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Lightweight texture (sometimes noted)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Potential irritation (sometimes noted)
- Liked: Firming effect (rarely noted)
- Disliked: Availability issues (rarely noted)
- Disliked: Strong fragrance (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### Why is Natura Bissé C+C Vitamin Complex a weak match for sensitive skin?

Natura Bisse C+C Vitamin Complex is a weak match for sensitive skin because it lacks specific ingredients to target redness and irritation. A treatment for this skin needs soothing ingredients like niacinamide and snail secretion filtrate to calm redness while supporting skin health safely.
Sources: [Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41309687/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32383548/)

### Which ingredients make this serum a poor fit for sensitive skin?

This serum is a weak match for sensitive skin because its ingredients target general brightening rather than calming redness and irritation. To fit this skin type well, a treatment needs soothing components like niacinamide and snail secretion filtrate.

### What does Vitamin C do for sensitive skin?

Vitamin C helps brighten skin, smooth out fine lines, and fade dark spots. Clinical studies show it is generally safe and well-tolerated when improving overall skin quality.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### What does Vitamin E do for sensitive skin?

Vitamin E helps calm sensitive skin by reducing redness, swelling, and irritation while strengthening the skin barrier against everyday environmental stress. Regular use is unlikely to cause trouble and may improve overall comfort.
Sources: [Archives of Biochemistry and Biophysics, 1992](https://pubmed.ncbi.nlm.nih.gov/1632644/), [Scanning Microscopy, 1993](https://pubmed.ncbi.nlm.nih.gov/8023094/)

### Where does it go in a skincare routine for sensitive skin?

This treatment goes in the evening routine for sensitive skin, applied after the soothing toner and before the moisturizer. While this product is generally safe and unlikely to cause irritation, it is a weak match because it does not target redness and irritation, so sensitive skin needs calming ingredients like centella asiatica and soothing plant extracts.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the vitamin C serum in the morning and saving your retinol for your evening routine. This timing helps you get the antioxidant benefits of Ascorbic Acid and Vitamin E safely while keeping redness and irritation less likely.

### How often should I use it?

This treatment is best used in the evening once a week for sensitive skin, and people who tolerate it well and see good results can carefully use it more often. Because this product is a weak match for sensitive skin, a treatment of this type needs soothing and calming ingredients like centella asiatica, green tea, or aloe vera to help manage redness and irritation.

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This treatment is unlikely to clog pores or cause breakouts for sensitive skin because its ingredients have a safe profile without harsh elements, though a product of this type needs calming agents and soothing botanical extracts to properly comfort sensitive skin.
Sources: [Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/)

### Is it fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, limonene, and linalool).

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — $53.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — $39.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — $25.08 at Amazon

## Routine for sensitive skin

### AM

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — $28.08 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — $28.05 at Amazon
- Moisturizer with Sun Protection: [innisfree Daily Mild Sunscreen](https://lovi.care/skincare/p/innisfree/daily-mild-sunscreen/for/sensitive-skin) — Superior fit — $18.00 at Amazon

### PM

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/p/missha/ultra-hyalon-cleansing-cream/for/sensitive-skin) — Superior fit — $21.70 at Amazon
- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — $28.08 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — $28.05 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/p/peach-and-lily/glass-skin-refining-serum/for/sensitive-skin) — Superior fit — $39.00 at Amazon
- Moisturizer: [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/sensitive-skin) — Superior fit — $22.00 at Amazon

### Weekly

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/p/missha/ultra-hyalon-cleansing-cream/for/sensitive-skin) — Superior fit — $21.70 at Amazon
- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — $28.08 at Amazon
- Enzyme Powder: [Fancl Facial Washing Powder](https://lovi.care/skincare/p/fancl/facial-washing-powder/for/sensitive-skin) — Superior fit — $22.00 at Amazon
- Nourishing Mask: [MEDIHEAL Vita Essential Mask](https://lovi.care/skincare/p/mediheal/vita-essential-mask/for/sensitive-skin) — Superior fit — $22.00 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/p/peach-and-lily/glass-skin-refining-serum/for/sensitive-skin) — Superior fit — $39.00 at Amazon
- Moisturizer: [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/sensitive-skin) — Superior fit — $22.00 at Amazon

## Where to buy

- Amazon.com: $165.00 (https://www.amazon.com/dp/B0032Z3CDW?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Sodium Ascorbyl Phosphate, Sodium Acrylates Copolymer, Propanediol, Glycerin, Hydrogenated Polyisobutene, Rosa Canina Oil Fruit, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Citric Acid, Tocopheryl Acetate, Anogeissus Leiocarpus Bark Extract, Helianthus Annuus Seed Oil Sunflower Seed Oil, Hydrolyzed Collagen, Sodium Chondroitin Sulfate, Prunus Amygdalus Dulcis Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Polysorbate 60, Sorbitan Stearate, Disodium Edta, Tocopherol, Potassium Sorbate, Phenoxyethanol, Parfum, Limonene, Linalool, Citrus Nobilis Oil Mandarin Orange Oil, Citrus Aurantium Dulcis Oil, Amyl Cinnamal, Yellow 5 Ci 19140
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin