# MISSHA Time Revolution Night Repair Probio Ampoule for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [MISSHA](https://lovi.care/skincare/brands/missha)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as Bifida Lysate Ferment and Niacinamide provide hydration and soothing benefits supportive for acne-prone skin, but they do not directly target blemishes.
- Glycerin and Niacinamide offer humectant action and potential seboregulation, which are beneficial for combination skin, though they may not fully address oiliness in your T-zone.
- The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-probio-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-probio-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-probio-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/p/missha/time-revolution-night-repair-probio-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-probio-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-probio-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-probio-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Bifida Lysate Ferment, Niacinamide, Sodium Hyaluronate, Probio Lactobacillus Complex, Panthenol

## What the research says

- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Probiotic-derived lotion successfully reduced inflammatory acne lesion counts and erythema index comparably to 2.5% benzoyl peroxide in patients with mild-to-moderate acne vulgaris, while causing fewer side effects. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35384257/))
- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))
- Lactobacillus plantarum extracellular vesicles modulated extracellular matrix related gene expression in vitro and suppressed wrinkle formation and pigmentation in clinical trials. ([Current Issues in Molecular Biology, 2022](https://pubmed.ncbi.nlm.nih.gov/35723322/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))

## Why other serums fit acne-prone skin better

- Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

This ampoule is frequently praised for delivering a 'glass skin' effect overnight, making dry and mature skin appear plump, hydrated, and glowing. A very large amount of data suggests that while it's a highly effective and affordable alternative to luxury serums, the high concentration of fermented ingredients may cause breakouts in individuals with fungal acne or sensitivities.

- Liked: Instant Glow (mostly mentioned)
- Liked: Deep Hydration (often mentioned)
- Liked: Lightweight Texture (often mentioned)
- Liked: Texture Improvement (sometimes noted)
- Liked: Value for Money (sometimes noted)
- Disliked: Breakouts & Reactions (sometimes noted)
- Disliked: Fragrance & Oils (sometimes noted)
- Disliked: Dropper Issues (rarely noted)
- Disliked: Ineffective for Some (rarely noted)
- Disliked: Sticky Residue (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does MISSHA Time Revolution Night Repair Probio Ampoule work for acne-prone skin?

This product works moderately well for acne-prone skin, providing soothing hydration while being gentle and safe, though it does not directly target blemishes. Acne-prone skin needs treatments with ingredients like niacinamide, propolis, or zinc PCA that directly target breakouts and help control oiliness.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for acne-prone skin?

Bifida Lysate Ferment and Niacinamide help make this serum a good fit for acne-prone skin by providing soothing benefits and hydration, though it does not directly target blemishes. To work best for acne-prone skin, a treatment of this type needs ingredients like niacinamide and zinc PCA to actively control oiliness and target breakouts while keeping skin balanced.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### What does Bifida Ferment Lysate do for acne-prone skin?

Bifida Ferment Lysate helps acne-prone skin by calming redness and keeping the skin barrier strong. This ingredient may also support the skin's defenses against irritation, making it less likely to flare up.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Putting it in the PM routine keeps things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the serum first to calm and hydrate your skin before following with your retinol product. This helps maintain moisture while minimizing potential dryness or irritation.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this treatment in your evening routine for simplicity and extra safety around sun exposure. It is safe for your skin with no risks of irritation, though acne-prone skin needs targeted blemish-fighting ingredients and oil-control agents to fully address breakouts and T-zone oiliness.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36798538/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to cause irritation for your acne-prone skin, but some reviewers do mention breakouts and reactions. Acne-prone skin works best with products that include targeted blemish-fighting ingredients and oil-balancing agents to properly clear pores.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — $28.88 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — $39.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — $15.60 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — $15.50 at Amazon

## Where to buy

- Amazon.com: $31.10 (https://www.amazon.com/dp/B09648RPKJ?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Bifida Lysate Ferment, Butylene Glycol, Glycerin, Propanediol, Betaine, Water, Niacinamide, Pentylene Glycol, 1,2-Hexanediol, Diethoxyethyl Succinate, Chondrus Crispus Extract, Squalane, Panthenol, Polyglyceryl-10 Laurate, Saccharum Officinarum Extract, Hydrogenated Lecithin, Carbomer, Tromethamine, Xanthan Gum, Polyquaternium-51, Ethylhexylglycerin, Adenosine, Dextrin, Theobroma Cacao Extract, Beta Vulgaris Root Extract, Brassica Oleracea Capitata Leaf Extract, Daucus Carota Sativa Root Extract Carrot Root Extract, Solanum Melongena Fruit Extract, Blueberry Fruit Extract, Bergamot Oil Fruit, Disodium Edta, Sodium Hyaluronate, Lactobacillus Soybean Extract Ferment, Leuconostoc Radish Root Ferment Filtrate, Bifida Ferment Filtrate, Lactobacillus Ferment, Lactobacillus Lysate Ferment, Lactobacillus Acerola Cherry Ferment, Lactobacillus Punica Granatum Extract Fruit Ferment, Pelargonium Graveolens Oil Flower, Helianthus Annuus Seed Oil Sunflower Seed Oil, Citrus Aurantium Dulcis Peel Oil, Lavandula Angustifolia Oil Lavender Oil, Lupinus Albus Seed Extract, Aspergillus Ferment, Swiftlet Nest Extract, Anthemis Nobilis Oil Flower, Sandalwood Oil, Tocopherol, Ceramide Np, Cholesterol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin