# MISSHA Time Revolution Night Repair Ampoule for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/missha/time-revolution-night-repair-ampoule/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [MISSHA](https://lovi.care/skincare/brands/missha)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for skin with dark spots; a few serums fit it even better.

## Why this fit

- Offers high suitability for your normal skin, as Bifida Lysate Ferment and Niacinamide work to repair your skin barrier and provide hydration. Ascorbyl tetraisopalmitate is also included to address your pigmentation concerns by promoting skin brightening and offering antioxidant effects.
- The formulation is safe for your normal skin, with Bifida Lysate Ferment and Chamomilla Recutita Flower Extract providing soothing benefits and minimizing irritation risk.
- This product is well-suited for your skin type and goals, offering effective treatment for pigmentation and barrier support.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-ampoule/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/missha/time-revolution-night-repair-ampoule/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-ampoule/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/missha/time-revolution-night-repair-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Bifida Lysate Ferment, Niacinamide, Retinol, Copper Tripeptide-1, Ubiquinone

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of CoQ10 improves mitochondrial function in aging skin in vivo, combating cellular signs of aging caused by an age-dependent shift to a functionally anaerobic energy metabolism. ([BioFactors, 2008](https://pubmed.ncbi.nlm.nih.gov/19096122/))
- Encapsulating coenzyme Q10 in lipid nanoparticles for topical use improves skin compatibility, protects against degradation, increases skin penetration, and provides controlled release to counteract aging effects. ([Colloids and Surfaces. B, Biointerfaces, 2023](https://pubmed.ncbi.nlm.nih.gov/37574615/))
- Review of topical administration of carotenoids and coenzyme Q10 loaded in lipid nanoparticles highlights their improved bioavailability, chemical stability, skin absorption, and photoprotective effects. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34206935/))

## What reviewers say

Based on a very large amount of data, this anti-aging overnight treatment is highly regarded for its ability to deeply hydrate, plump, and brighten the skin, significantly improving texture and reducing fine lines, particularly for those with dry, mature, or dull complexions. While generally well-tolerated, a moderate number of users with sensitive or acne-prone skin reported experiencing breakouts or irritation, and a small number noted a sticky or oily feel and a noticeable herbal scent.

- Liked: Deeply hydrates skin (mostly mentioned)
- Liked: Brightens and adds glow (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Affordable luxury dupe (sometimes noted)
- Disliked: May cause breakouts (sometimes noted)
- Disliked: Feels sticky or oily (rarely noted)
- Disliked: Noticeable herbal scent (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes MISSHA Night Repair Ampoule a great fit for skin with dark spots?

This treatment is a great fit because Niacinamide and Ascorbyl Tetraisopalmitate work to brighten dark spots, while Bifida Lysate Ferment and Niacinamide help repair your skin barrier and provide hydration. These ingredients make it very suitable for addressing pigmentation concerns safely and effectively.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Which ingredients make this serum a good fit for skin with dark spots?

This serum is a great fit for skin with dark spots because it includes Niacinamide and Ascorbyl Tetraisopalmitate, which help fade dark spots and brighten your complexion. Niacinamide works by slowing down pigment transfer, while Ascorbyl Tetraisopalmitate supports cell renewal and reduces pigmentation.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### What does Bifida Ferment Lysate do for skin with dark spots?

Bifida Ferment Lysate helps strengthen the skin barrier and calm irritation, making it a supportive addition for skin with dark spots. It works to keep your skin balanced and protected against daily stress, which may prevent new marks from forming.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Niacinamide do for skin with dark spots?

Niacinamide helps fade dark spots and uneven pigmentation by slowing down the transfer of pigment in the skin. It is generally well tolerated and may improve overall skin brightness with consistent use.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for skin with dark spots?

This treatment serum goes in the evening routine after cleansing and before moisturizing, which keeps it simple and safe for your skin. Niacinamide and retinol help address dark spots and support the skin barrier while you sleep.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38406974/)

### Can I use this serum with AHA, and in what order?

You can use this treatment alongside an AHA by applying the AHA first, letting it absorb, and then following with this serum. Because both products contain active ingredients that may cause dryness or irritation, you should introduce them slowly into your routine to ensure your skin adjusts comfortably.

### How often should I use this serum?

This treatment is intended for evening use, starting once a week and gradually increasing frequency as your skin adjusts. The formula helps address dark spots while supporting your skin barrier, with ingredients like niacinamide and retinol that improve skin tone and texture.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38406974/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This product may occasionally cause breakouts, as reviewers note this risk for skin with dark spots. However, its ingredients like Niacinamide and Bifida Lysate Ferment generally support a healthy barrier and are unlikely to cause severe issues.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [AMOREPACIFIC Time Response Skin Reserve Serum](https://lovi.care/skincare/p/amorepacific/time-response-skin-reserve-serum/for/dark-spots) — Superior fit — $525.00 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots) — Superior fit — $53.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dark-spots) — High fit — $16.75 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — $16.99 at Amazon
- Moisturizer: [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/p/isntree/green-tea-fresh-serum/for/dark-spots) — Superior fit — $17.90 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Bifida Lysate Ferment, Glycereth-26, Juniperus Chinensis Xylem Extract, Sorbus Commixta Extract, Bis-Peg-18 Methyl Ether Dimethyl Silane, Butylene Glycol, Glycerin, Niacinamide, Betaine, Leuconostoc Radish Ferment Filtrate, Cyclopentasiloxane, Ethyl Hexanediol, Dimethicone, Grifola Frondosa Extract Ferment Filtrate Maitake Extract Ferment Filtrate Ophioglossum Vulgatum Extract Ferment Filtrate, Peg-11 Methyl Ether Dimethicone, Peg-40 Hydrogenated Castor Oil, Ppg-26-Buteth-26, Polysorbate 20, Carbomer, Glyceryl Caprylate, Triethanolamine, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Dimethicone Vinyl Dimethicone Crosspolymer, Hydrolyzed Rice Extract, Lactobacillus Rice Ferment Filtrate, Portulaca Oleracea Extract, Sea Water, Sodium Hyaluronate, Octyldodecanol, Carthamus Tinctorius Oleosomes, Acacia Arabica Bark Extract Stem, Hydrolyzed Extensin, Adenosine, Xanthan Gum, Aronia Arbutifolia Extract, Beta Vulgaris Root Extract, Brassica Oleracea Capitata Leaf Extract, Daucus Carota Sativa Root Extract Carrot Root Extract, Blueberry Fruit Extract, Dipropylene Glycol, Echium Plantagineum Seed Oil, Tocopheryl Acetate, Cyclomethicone, Hydrogenated Lecithin, Disodium Edta, Ascorbyl Tetraisopalmitate, Dextrin, Lactobacillus Ferment, Lactococcus Lysate Ferment, Laminaria Digitata Extract, Manilkara Multinervis Leaf Extract, Theobroma Cacao Seed Extract, Lauryl Methacrylate Glycol Dimethacrylate Crosspolymer, Saccharomyces Ferment Filtrate, Lactobacillus Soybean Extract Ferment, Glyceryl Polyacrylate, Saccharomyces Viscum Album Extract Ferment Mistletoe Extract Ferment, Yeast Extract Ferment, Pogostemon Cablin Oil, Dimethiconol, Cardiospermum Halicacabum Vine Extract Flower Leaf, Helianthus Annuus Seed Oil Sunflower Seed Oil, Pseudoalteromonas Extract Ferment, Alpha-Glucan Oligosaccharide, Limnanthes Alba Seed Oil, Hydrolyzed Wheat Protein, Beta-Sitosterol, Panthenol, Hydrolyzed Soy Protein, Propylene Glycol, Cholesterol, Ceteth-24, Choleth-24, Glyceryl Arachidonate, Glyceryl Linoleate, Glyceryl Linolenate, Ubiquinone, Hydroxypropyltrimonium Maltodextrin Crosspolymer, Cetyl Phosphate, Caprylic Capric Triglyceride, Macadamia Ternifolia Seed Oil, Retinol, Lecithin, Phenoxyethanol, Cucumis Melo Fruit Extract, Amaranthus Caudatus Seed Extract, Biotin, Brassica Campestris Sterols, Peg-5 Rapeseed Sterol, Sodium Ascorbyl Phosphate, Tripeptide-10 Citrulline, Acetyl Hexapeptide-8, Bht, Ceteth-3, Ceteth-5, Copper Tripeptide-1, Silica, Tripeptide-1
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/missha/time-revolution-night-repair-ampoule/for/dark-spots (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/missha/time-revolution-night-repair-ampoule/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/missha/time-revolution-night-repair-ampoule/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-ampoule/for/dark-spots
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- Italy: https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-ampoule/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/missha/time-revolution-night-repair-ampoule/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/missha/time-revolution-night-repair-ampoule/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/missha/time-revolution-night-repair-ampoule/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/missha/time-revolution-night-repair-ampoule/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/missha/time-revolution-night-repair-ampoule/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/missha/time-revolution-night-repair-ampoule/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-ampoule/for/dark-spots