# Medik8 Liquid Peptides for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/medik8/liquid-peptides/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Medik8](https://lovi.care/skincare/brands/medik8)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate plumping and firming for your oily skin due to Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-1, which improve elasticity and reduce fine lines, though these peptides do not directly target your acne or breakouts.
- Glycerin and Hyaluronic Acid provide general hydration and skin conditioning beneficial for oily skin, supporting overall skin health without exacerbating oiliness.
- The product is safe for your oily skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/medik8/liquid-peptides/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## Why other serums fit oily acne-prone skin better

- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Users consistently praise this serum as a "Botox in a bottle" alternative that delivers immediate hydration and visible plumping, particularly for fine lines on the forehead and around the eyes. It is widely celebrated for its ability to smooth skin texture and restore bounce to dry or mature skin without causing irritation, making it a staple for those targeting early to advanced signs of aging.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Elegant, lightweight texture (often mentioned)
- Liked: Visibly plumps and smooths (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Gentle and non-irritating (sometimes noted)
- Disliked: Packaging fragility (sometimes noted)
- Disliked: Results require patience (rarely noted)
- Disliked: Slight tackiness (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Medik8 Liquid Peptides work for oily acne-prone skin?

Medik8 Liquid Peptides works moderately well for oily acne-prone skin, offering general hydration and firming without triggering excess oil, even though its peptides do not directly target breakouts. A treatment for this skin needs ingredients like niacinamide, propolis, or Vitamin C to control excess oil and clear blemishes while keeping the skin calm and comfortable.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Glycerin and hyaluronic acid make this serum a good fit for oily acne-prone skin by providing general hydration and skin conditioning without exacerbating oiliness, while acetyl hexapeptide-8 and palmitoyl tripeptide-1 offer moderate plumping and firming. However, because this product does not directly target breakouts, treatments for this skin type need to include ingredients like niacinamide, propolis, or vitamin C to actively address acne and blemishes while controlling excess oil.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### What does Argireline do for oily acne-prone skin?

Argireline is unlikely to treat acne or oiliness directly, as it focuses on reducing fine lines and making skin smooth. Oily acne-prone skin needs lightweight, non-greasy ingredients that clear pores and calm breakouts.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Palmitoyl Tripeptide-1 do for oily acne-prone skin?

Palmitoyl tripeptide-1 helps firm the skin and smooth out fine lines, but it is not specifically designed to treat oily or acne-prone skin. To care for oily and acne-prone skin while targeting aging, this type of product needs lightweight hydrators and pore-clearing ingredients that keep the skin clear without feeling heavy.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in your evening routine, applied after cleansing and toning and before moisturizing. Oily acne-prone skin needs a treatment that contains blemish-clearing actives like salicylic acid or niacinamide to help directly target breakouts alongside anti-aging ingredients.

### Can I use this serum with retinol, and in what order?

You can use this serum in your evening routine after cleansing and before your moisturizer. It is unlikely to cause irritation on oily skin, but to treat breakouts effectively, this skin type also needs targeted acne-fighting ingredients like salicylic acid or benzoyl peroxide.
Sources: [American Family Physician, 2012](https://pubmed.ncbi.nlm.nih.gov/23062156/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### How often should I use this serum?

This treatment works well in the evening for your oily acne-prone skin, helping smooth fine lines without causing irritation. Oily acne-prone skin needs a treatment that controls breakouts and clears pores with active ingredients like salicylic acid or retinoids.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to clog pores or cause breakouts for oily acne-prone skin. It contains hydrating ingredients that support overall skin health without adding excess oil, though an oily acne-prone skin also needs targeted ingredients that actively clear pores and manage blemishes.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — $25.08 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — $25.08 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $95.00 (https://www.amazon.com/dp/B0DT1LYVZ6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycerin, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Carbomer, Phenoxyethanol, Ethylhexylglycerin, Hyaluronic Acid, Lecithin, Caprylyl Glycol, Disodium Edta, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medik8/liquid-peptides/for/oily-acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/medik8/liquid-peptides/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medik8/liquid-peptides/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medik8/liquid-peptides/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/medik8/liquid-peptides/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medik8/liquid-peptides/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medik8/liquid-peptides/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/medik8/liquid-peptides/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/medik8/liquid-peptides/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medik8/liquid-peptides/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/medik8/liquid-peptides/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medik8/liquid-peptides/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medik8/liquid-peptides/for/oily-acne-prone-skin