# Medik8 Liquid Peptides for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/medik8/liquid-peptides/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Medik8](https://lovi.care/skincare/brands/medik8)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other serums fit it better.

## Why this fit

- Excellent suitability for your dry skin is provided by humectants like glycerin and hyaluronic acid, which draw moisture to the skin, complemented by lecithin's emollient properties for enhanced hydration.
- The peptides, Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-1, offer good plumping and firming benefits, addressing your skin's need for hydration and a smoother appearance.
- The product is safe for your dry skin, as it contains no harsh or irritating ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/medik8/liquid-peptides/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/medik8/liquid-peptides/for/oily-acne-prone-skin): Average

## Key ingredients

Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Lecithin-based nanoemulsions showed superior viability in human skin cells compared to SDS-based formulations, with components remaining in superficial stratum corneum layers indicating low skin irritation risk. ([International Journal of Pharmaceutics, 2020](https://pubmed.ncbi.nlm.nih.gov/32165223/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## What reviewers say

Users consistently praise this serum as a "Botox in a bottle" alternative that delivers immediate hydration and visible plumping, particularly for fine lines on the forehead and around the eyes. It is widely celebrated for its ability to smooth skin texture and restore bounce to dry or mature skin without causing irritation, making it a staple for those targeting early to advanced signs of aging.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Elegant, lightweight texture (often mentioned)
- Liked: Visibly plumps and smooths (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Gentle and non-irritating (sometimes noted)
- Disliked: Packaging fragility (sometimes noted)
- Disliked: Results require patience (rarely noted)
- Disliked: Slight tackiness (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Medik8 Liquid Peptides work for dry skin?

Medik8 Liquid Peptides works for your dry skin, though other products fit it better. It helps draw moisture and smooth your skin with glycerin, hyaluronic acid, and peptides, but dry skin typically needs a treatment rich in deeper hydrators, barrier-supporting ceramides, and soothing ingredients like niacinamide or propolis for the best results.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### Which ingredients make this serum a good fit for dry skin?

Glycerin and hyaluronic acid draw moisture into dry skin, while lecithin softens it and peptides help smooth its appearance. To fit dry skin even better, a treatment of this type needs deeply soothing and barrier-supporting ingredients like ceramides, niacinamide, and antioxidants.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### What does Argireline do for dry skin?

Argireline helps smooth out fine lines and reduce skin roughness when applied twice a day. It may also improve overall hydration, though it works best when paired with ingredients that deeply moisturize dry skin.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Palmitoyl Tripeptide-1 do for dry skin?

Palmitoyl tripeptide-1 helps improve firmness, smoothness, and overall skin architecture. When paired with the right routine, it may also help reduce the appearance of fine lines and wrinkles by supporting collagen levels.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/)

### Where does this serum go in a skincare routine for dry skin?

This treatment goes in the evening routine after cleansing and before moisturizing. A product of this type needs ingredients that draw moisture to the skin like glycerin and hyaluronic acid, softening ingredients like lecithin, and plumping peptides for dry skin.

### Can I use it with retinol, and in what order?

You can use this treatment with retinol by applying the treatment first in your evening routine, followed by your moisturizer. This product helps smooth and firm the skin while being safe and free of harsh ingredients, though dry skin generally benefits most from added moisture-attracting humectants and softening ingredients.

### How often should I use this serum?

You can use this serum in your evening routine, applying it after cleansing and before your moisturizer. To best support dry skin, products of this type need hydrating ingredients like glycerin and hyaluronic acid to draw moisture, softening ingredients for enhanced hydration, and firming peptides.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### Can it clog pores, cause breakouts or purging for dry skin?

This product is unlikely to clog pores or cause breakouts for dry skin. It contains no heavy or greasy ingredients that typically block pores, making it safe for your skin type.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — $16.75 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — $53.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — $19.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — $19.99 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — $16.99 at Amazon
- Moisturizer: [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/dry-skin) — Superior fit — $22.00 at Amazon

## Where to buy

- Amazon.com: $95.00 (https://www.amazon.com/dp/B0DT1LYVZ6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycerin, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Carbomer, Phenoxyethanol, Ethylhexylglycerin, Hyaluronic Acid, Lecithin, Caprylyl Glycol, Disodium Edta, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medik8/liquid-peptides/for/dry-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/medik8/liquid-peptides/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/medik8/liquid-peptides/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/medik8/liquid-peptides/for/dry-skin
- France: https://lovi.care/skincare/fr/p/medik8/liquid-peptides/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/medik8/liquid-peptides/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/medik8/liquid-peptides/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/medik8/liquid-peptides/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/medik8/liquid-peptides/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/medik8/liquid-peptides/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/medik8/liquid-peptides/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medik8/liquid-peptides/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medik8/liquid-peptides/for/dry-skin