# Mediheal N.M.F Intensive Hydrating Cream for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/p/mediheal/n-m-f-intensive-hydrating-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Mediheal](https://lovi.care/skincare/brands/mediheal)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Excellent for your normal skin, this product effectively addresses wrinkles and fine lines with ingredients like Adenosine and Copper Tripeptide-1, which promote collagen synthesis and elasticity, complemented by Tremella Fuciformis Extract Mushroom Extract and Sodium Hyaluronate for superior hydration.
- Glycerin and Centella Asiatica Extract further support skin health by providing humectant and soothing benefits, ensuring a comfortable and beneficial experience.
- The formulation is safe for your skin, containing no harsh ingredients and including soothing extracts that minimize irritation risk.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/mediheal/n-m-f-intensive-hydrating-cream/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/mediheal/n-m-f-intensive-hydrating-cream/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/p/mediheal/n-m-f-intensive-hydrating-cream/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/mediheal/n-m-f-intensive-hydrating-cream/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/p/mediheal/n-m-f-intensive-hydrating-cream/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/mediheal/n-m-f-intensive-hydrating-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/mediheal/n-m-f-intensive-hydrating-cream/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/mediheal/n-m-f-intensive-hydrating-cream/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/p/mediheal/n-m-f-intensive-hydrating-cream/for/oily-acne-prone-skin): High

## Key ingredients

N.M.F, Sodium Hyaluronate, Hydrolyzed Collagen, Tremella Fuciformis Extract Mushroom Extract, Centella Asiatica Extract

## What the research says

- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Snow mushroom alcohol-based hand rub gel significantly improved skin moisture better than the placebo through 180 minutes while maintaining comparable antiseptic efficacy in 20 human volunteers. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32531816/))
- Tremella fuciformis extract demonstrates potential cutaneous benefits including skin antiaging, photoprotection, wound healing, and barrier protection based on in vitro and animal models. ([Archives of Dermatological Research, 2023](https://pubmed.ncbi.nlm.nih.gov/36757441/))
- Tremella fuciformis inhibits melanogenesis by decreasing melanin content and tyrosinase expression in B16F10 cells while promoting wound healing in human HaCaT keratinocytes and Detroit 551 fibroblasts. ([In Vivo, 2022](https://pubmed.ncbi.nlm.nih.gov/35241526/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))

## What reviewers say

Based on limited data, this rich cream is highly praised for deeply hydrating dry and dehydrated skin, creating a protective barrier. Users love its emollient texture that leaves skin soft and smooth with a non-sticky finish. However, a small number of users have reported severe allergic reactions, and the product is currently very difficult to find.

- Liked: Deep hydration (mostly mentioned)
- Disliked: Product availability (mostly mentioned)
- Liked: Rich texture (often mentioned)
- Liked: Non-sticky finish (sometimes noted)
- Liked: Softens skin (sometimes noted)
- Disliked: Too heavy (sometimes noted)
- Disliked: Allergic reactions (rarely noted)
- Disliked: Fragrance sensitivity (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Mediheal N.M.F Intensive Hydrating Cream one of the best fits for mature skin?

This cream is one of the best fits for mature skin because it tackles wrinkles and fine lines with ingredients like Adenosine and Copper Tripeptide-1 to boost elasticity, while Sodium Hyaluronate and mushroom extract provide deep hydration. It also includes Glycerin and Centella Asiatica Extract to calm and comfort your skin with a very low risk of irritation.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for mature skin?

Adenosine and Copper Tripeptide-1 make this cream a great fit for mature skin by helping smooth wrinkles and fine lines, while Sodium Hyaluronate and Tremella Fuciformis Extract Mushroom Extract bring deep hydration to keep skin soft and plump. Glycerin and Centella Asiatica Extract further support skin health by adding moisture and calming the skin.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What do Natural Moisturizing Factors do for mature skin?

Natural moisturizing factors help keep mature skin feeling soft and smooth by holding onto water and supporting the outer skin barrier. Because aging skin can lose moisture easily, these components help maintain comfortable hydration and a healthy balance.
Sources: [Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41422283/), [Dermatologic Therapy, 2004](https://pubmed.ncbi.nlm.nih.gov/14728698/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this cream go in a skincare routine for mature skin?

This cream is used as the moisturizer step in both your morning and evening routines. It helps smooth fine lines and provides deep hydration while keeping your skin calm and comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this cream with retinol, and in what order?

Yes, you can use this cream with retinol by applying the retinol first and following with this moisturizer to help keep your skin comfortable and hydrated. Using a nourishing moisturizer alongside retinol helps reduce dryness and supports your skin barrier while you treat fine lines and wrinkles.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/)

### How often should I use this cream?

This cream is well suited for daily use to keep mature skin hydrated and smooth. Applying it regularly helps soften fine lines and maintains a comfortable, healthy moisture barrier.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin, as it has a very safe formula with soothing extracts that help keep irritation low. While some reviewers occasionally find it a bit heavy, it provides deep hydration and targets fine lines without harsh ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/)

### Can I use this cream around the eyes or on my body?

This cream is safe to use around the eyes and on the body because it features a gentle formula with soothing extracts that minimize the risk of irritation. Ingredients like hyaluronic acid and plant extracts help smooth fine lines and boost hydration in delicate areas.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon
- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/mature-skin) — Superior fit — $22.00 at Amazon
- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — $120.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — $46.00 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Cetyl Ethylhexanoate, Sea Water, Glycerin, Caprylic Capric Triglyceride, Butylene Glycol, 1,2-Hexanediol, Glyceryl Stearate, Peg-100 Stearate, Stearic Acid, Dimethicone, Cetearyl Alcohol, Tremella Fuciformis Extract Mushroom Extract, Sugar Maple Extract, Sodium Polyacrylate, Sorbitan Sesquioleate, Hydrogenated Polydecene, Phenoxyethanol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Tocopheryl Acetate, Hydrolyzed Collagen, Rosa Centifolia Flower Water, Honey Extract, Parfum, Allantoin, Adenosine, Disodium Edta, Trideceth-6, Sodium Hyaluronate, Centella Asiatica Extract, Copper Tripeptide-1, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mediheal/n-m-f-intensive-hydrating-cream/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/mediheal/n-m-f-intensive-hydrating-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/mediheal/n-m-f-intensive-hydrating-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/mediheal/n-m-f-intensive-hydrating-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/mediheal/n-m-f-intensive-hydrating-cream/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/mediheal/n-m-f-intensive-hydrating-cream/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/mediheal/n-m-f-intensive-hydrating-cream/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/mediheal/n-m-f-intensive-hydrating-cream/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/mediheal/n-m-f-intensive-hydrating-cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/mediheal/n-m-f-intensive-hydrating-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/mediheal/n-m-f-intensive-hydrating-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/mediheal/n-m-f-intensive-hydrating-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/mediheal/n-m-f-intensive-hydrating-cream/for/mature-skin