# MEDIHEAL Collagen Ampoule Pad for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [MEDIHEAL](https://lovi.care/skincare/brands/mediheal)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- Offers excellent moisturizing and treatment for your oily skin, as collagen extract and multiple peptides hydrate and improve skin elasticity, though it lacks strong seboregulating ingredients to directly address acne and breakouts.
- The presence of glycerin and hydroxyethyl urea provides humectant action, supporting overall skin hydration for oily skin.
- The product is safe for your oily skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like Dipotassium Glycyrrhizate and Anthemis Nobilis Oil Flower.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Collagen Extract, Adenosine, Ceramide Np, Betaine, Lactobacillus Ferment

## What the research says

- Collagen peptides induced cell proliferation and pro-collagen-1α expression, increased TGF-β and VEGF, and suppressed the LPS-induced inflammatory response in human skin fibroblasts and keratinocytes. ([Nutrients, 2022](https://pubmed.ncbi.nlm.nih.gov/36501011/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A topical formulation containing panthenol, niacinamide, and dipotassium glycyrrhizate increased skin hydration by 74.1% and reduced transepidermal water loss by 13.5% at 28 days compared to baseline and untreated control in 35 individuals with xerosis. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42108609/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Topical dry mouth products containing olive oil, betaine, and xylitol significantly increased unstimulated whole salivary flow rates, reduced xerostomia complaints, and improved quality of life in adults with polypharmacy-induced xerostomia compared to their normal routine care, with no clinically significant adverse events. ([Journal of Oral Rehabilitation, 2007](https://pubmed.ncbi.nlm.nih.gov/17824884/))
- Soaps containing betaine caused the least skin irritation compared to other tested soaps in twenty-eight healthy subjects, though irritation did not decrease with increasing concentrations of betaine. ([Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/))
- A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/))
- Probiotic-derived lotion successfully reduced inflammatory acne lesion counts and erythema index comparably to 2.5% benzoyl peroxide in patients with mild-to-moderate acne vulgaris, while causing fewer side effects. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35384257/))
- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))
- Lactobacillus plantarum extracellular vesicles modulated extracellular matrix related gene expression in vitro and suppressed wrinkle formation and pigmentation in clinical trials. ([Current Issues in Molecular Biology, 2022](https://pubmed.ncbi.nlm.nih.gov/35723322/))

## What reviewers say

Based on a very large amount of data, users consistently praise these pads for their ability to deeply hydrate and plump the skin, often describing a "glass skin" effect that serves as an excellent base for makeup. They are highly effective for soothing redness and improving texture on sensitive skin. Some users note a sticky finish and a fragrance that may not suit everyone.

- Liked: Deep hydration & plumping (mostly mentioned)
- Liked: Generous essence (often mentioned)
- Liked: Versatile & convenient (often mentioned)
- Liked: High-quality pad (sometimes noted)
- Liked: Soothing & cooling (sometimes noted)
- Disliked: Noticeable fragrance (sometimes noted)
- Disliked: Lack of immediate glow (rarely noted)
- Disliked: Price and value (rarely noted)
- Disliked: Sticky residue (rarely noted)

## How to apply

- Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
- Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
- Gently press a small amount into your skin and avoid rubbing to keep pores clear.
- Apply on clean, slightly damp skin to help the product absorb better and control oil.
- Avoid the sensitive eye area and do a simple patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes MEDIHEAL Collagen Ampoule Pad a great fit for oily acne-prone skin?

This product is a great fit because collagen extract and multiple peptides hydrate and improve skin elasticity, while glycerin and hydroxyethyl urea help keep oily skin properly hydrated. It is also safe and unlikely to cause irritation thanks to soothing components and the absence of harsh ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Nutrients, 2022](https://pubmed.ncbi.nlm.nih.gov/36501011/)

### Which ingredients make this pad a good fit for oily acne-prone skin?

Collagen extract and multiple peptides make this pad a great fit by hydrating and improving skin elasticity without clogging pores. Glycerin and hydroxyethyl urea also help keep oily skin comfortable and balanced, while soothing components keep irritation unlikely.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Collagen Extract do for oily acne-prone skin?

Collagen Extract is unlikely to clog pores and may help calm oily, acne-prone skin by supporting skin repair and reducing inflammation. This type of product works best when it also includes ingredients like niacinamide or gentle exfoliating acids to help balance oil and keep pores clear.
Sources: [Nutrients, 2022](https://pubmed.ncbi.nlm.nih.gov/36501011/), [Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611748/)

### What does Adenosine do for oily acne-prone skin?

Adenosine helps calm oily, acne-prone skin and supports a smooth, balanced look. It is generally well-tolerated and is unlikely to clog pores or cause irritation.
Sources: [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/), [The Journal of Clinical Investigation, 2014](https://pubmed.ncbi.nlm.nih.gov/25061872/)

### Where does this pad go in a skincare routine for oily acne-prone skin?

This treatment pad goes in your evening routine, after cleansing and before your moisturizer. It is unlikely to cause irritation on oily skin, but to directly address breakouts it needs extra oil-balancing ingredients.

### Can I use it with retinol, and in what order?

You can use this treatment alongside retinol to help keep your skin hydrated and comfortable. Apply the retinol first, let it absorb, and then follow with this moisturizing treatment.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this pad?

You can use this pad in your evening routine, applying it once a week at first, and then using it more often if your skin tolerates it well and you see good results. It is safe for your oily skin and is unlikely to cause irritation.

### Can it clog pores, cause breakouts or purging for oily acne-prone skin?

This product is a great fit for oily acne-prone skin because it hydrates well without causing irritation, though it does not directly treat breakouts. It is unlikely to clog pores or cause purging, and soothing ingredients help keep skin calm.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42108609/)

### Can I use it around the eyes or on my body?

This product is a great fit for your oily acne-prone skin, offering deep moisture and soothing care without heavy oils. Because the skin around your eyes is thin, you can safely apply this gentle treatment there, and it works equally well on the skin of your body.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this pad fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/oily-acne-prone-skin) — Superior fit — $8.40 at Amazon
- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/oily-acne-prone-skin) — High fit — $125.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — $25.60 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-acne-prone-skin) — Superior fit — $25.99 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Glycereth-26, 1,2-Hexanediol, Diphenyl Dimethicone, Triethylhexanoin, Betaine, Hydroxyacetophenone, Hydrogenated Lecithin, Polyglyceryl-10 Oleate, Hydroxyethyl Urea, Dipotassium Glycyrrhizate, Sodium Citrate, Allantoin, Octyldodeceth-16, Xanthan Gum, Hydroxyethylcellulose, Collagen Extract, Adenosine, Citric Acid, Disodium Edta, Olea Europaea Oil Fruit Olive Oil Fruit, Butylene Glycol, Pelargonium Graveolens Oil Flower, Lavandula Angustifolia Oil Lavender Oil, Anthemis Nobilis Oil Flower, Citrus Aurantium Dulcis Peel Oil, Juniperus Mexicana Oil, Mangifera Indica Fruit Extract, Lactobacillus Ferment, Ceramide Np, Extract Milk Protein, Caprylyl Glycol, Tripeptide-1, Acetyl Hexapeptide-8, Copper Tripeptide-1, Palmitoyl Tripeptide-1, Palmitoyl Pentapeptide-4
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin