# MEDIHEAL Collagen Ampoule Pad for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [MEDIHEAL](https://lovi.care/skincare/brands/mediheal)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- This formulation offers high suitability for your combination skin, with glycerin and hydroxyethyl urea providing excellent humectant action to hydrate the skin.
- While collagen extract and multiple peptides work to improve skin elasticity and offer general soothing benefits, the absence of ingredients like salicylic acid means it does not directly target your acne, blemishes, and breakouts.
- The safety profile is excellent, with no risks of irritation due to the absence of prohibited or harsh ingredients for your skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin): High

## Key ingredients

Collagen Extract, Adenosine, Ceramide Np, Betaine, Lactobacillus Ferment

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Soaps containing betaine caused the least skin irritation compared to other tested soaps in twenty-eight healthy subjects, though irritation did not decrease with increasing concentrations of betaine. ([Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Topical dry mouth products containing olive oil, betaine, and xylitol significantly increased unstimulated whole salivary flow rates, reduced xerostomia complaints, and improved quality of life in adults with polypharmacy-induced xerostomia compared to their normal routine care, with no clinically significant adverse events. ([Journal of Oral Rehabilitation, 2007](https://pubmed.ncbi.nlm.nih.gov/17824884/))
- A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/))
- Mixed surfactant systems of sodium dodecyl sulfate and dimethyl dodecyl amido betaine significantly reduce acute skin irritation potential in human volunteers compared with the individual surfactants, demonstrating that irritation potential cannot be predicted by simple summation. ([Food and Chemical Toxicology, 1998](https://pubmed.ncbi.nlm.nih.gov/9609395/))
- Probiotic-derived lotion successfully reduced inflammatory acne lesion counts and erythema index comparably to 2.5% benzoyl peroxide in patients with mild-to-moderate acne vulgaris, while causing fewer side effects. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35384257/))
- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))
- Lactobacillus plantarum extracellular vesicles modulated extracellular matrix related gene expression in vitro and suppressed wrinkle formation and pigmentation in clinical trials. ([Current Issues in Molecular Biology, 2022](https://pubmed.ncbi.nlm.nih.gov/35723322/))

## What reviewers say

Based on a very large amount of data, users consistently praise these pads for their ability to deeply hydrate and plump the skin, often describing a "glass skin" effect that serves as an excellent base for makeup. They are highly effective for soothing redness and improving texture on sensitive skin. Some users note a sticky finish and a fragrance that may not suit everyone.

- Liked: Deep hydration & plumping (mostly mentioned)
- Liked: Generous essence (often mentioned)
- Liked: Versatile & convenient (often mentioned)
- Liked: High-quality pad (sometimes noted)
- Liked: Soothing & cooling (sometimes noted)
- Disliked: Noticeable fragrance (sometimes noted)
- Disliked: Lack of immediate glow (rarely noted)
- Disliked: Price and value (rarely noted)
- Disliked: Sticky residue (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes MEDIHEAL Collagen Ampoule Pad a great fit for acne-prone skin?

This product is a great fit for your acne-prone skin because it hydrates deeply with ingredients like glycerin while offering soothing benefits, and it has an excellent safety profile without harsh or irritating ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this treatment a good fit for acne-prone skin?

Glycerin and hydroxyethyl urea make this treatment a great fit by providing deep hydration for acne-prone skin, while calming ingredients like allantoin and betaine help soothe irritation. Its gentle formulation has an excellent safety profile with very low risk of causing breakouts or redness.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Collagen Extract do for acne-prone skin?

Collagen Extract is unlikely to clog pores and may help soothe redness and keep acne-prone skin calm. Because this type of product is a poor fit for oily skin, acne-prone skin needs lightweight formulas with soothing ingredients and gentle acne-fighting extracts to stay clear and smooth.
Sources: [Nutrients, 2022](https://pubmed.ncbi.nlm.nih.gov/36501011/)

### What does Adenosine do for acne-prone skin?

Adenosine helps calm acne-prone skin by reducing redness and swelling. It is unlikely to clear breakouts on its own, so acne-prone skin needs ingredients that clear pores and balance oil, like salicylic acid.
Sources: [Experimental Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24889129/)

### Where does this treatment go in a skincare routine for acne-prone skin?

This treatment goes in your evening routine as a step after cleansing and toning, and before moisturizing. Lovi routines put treatments in the evening for simplicity and extra safety around sun exposure.

### Can I use this treatment with retinol, and in what order?

Yes, you can use this treatment with retinol by applying it right before your retinol step to help keep your skin calm and hydrated. This approach is unlikely to cause irritation because the product has a very gentle safety profile and lacks harsh ingredients.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this treatment?

You can use this treatment in your evening routine, applying it once a day or a few times a week as your skin adjusts. The formula has an excellent safety profile with no harsh ingredients, so it is unlikely to cause irritation.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this treatment clog pores, cause breakouts or purging for acne-prone skin?

This treatment is unlikely to clog pores or cause breakouts on acne-prone skin because it has an excellent safety profile with no harsh ingredients. While it hydrates and soothes, it lacks ingredients like salicylic acid, so it does not directly target active breakouts.
Sources: [Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/)

### Can I use this treatment around the eyes or on my body?

You can safely use this moisturizing treatment around the eyes and on the body because it features a very safe formula with no harsh ingredients. The thin skin around the eyes and various body areas readily tolerate its hydrating ingredients, such as glycerin and betaine, which help keep skin soft and smooth without irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/acne-prone-skin) — Superior fit — $8.40 at Amazon
- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/acne-prone-skin) — High fit — $125.00 at Amazon
- [SK-II LXP Ultimate Revival Essence](https://lovi.care/skincare/p/sk-ii/ultimate-revival-essence/for/acne-prone-skin) — High fit — $315.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — $15.60 at Amazon
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/p/d-alba/piedmont-waterfull-mild-sunscreen/for/acne-prone-skin) — Superior fit — $15.99 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Glycereth-26, 1,2-Hexanediol, Diphenyl Dimethicone, Triethylhexanoin, Betaine, Hydroxyacetophenone, Hydrogenated Lecithin, Polyglyceryl-10 Oleate, Hydroxyethyl Urea, Dipotassium Glycyrrhizate, Sodium Citrate, Allantoin, Octyldodeceth-16, Xanthan Gum, Hydroxyethylcellulose, Collagen Extract, Adenosine, Citric Acid, Disodium Edta, Olea Europaea Oil Fruit Olive Oil Fruit, Butylene Glycol, Pelargonium Graveolens Oil Flower, Lavandula Angustifolia Oil Lavender Oil, Anthemis Nobilis Oil Flower, Citrus Aurantium Dulcis Peel Oil, Juniperus Mexicana Oil, Mangifera Indica Fruit Extract, Lactobacillus Ferment, Ceramide Np, Extract Milk Protein, Caprylyl Glycol, Tripeptide-1, Acetyl Hexapeptide-8, Copper Tripeptide-1, Palmitoyl Tripeptide-1, Palmitoyl Pentapeptide-4
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin