# MEDIHEAL AGE-R for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/mediheal/age-r/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [MEDIHEAL](https://lovi.care/skincare/brands/mediheal)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your wrinkles and fine lines as collagen and peptides support skin elasticity and reduce the appearance of aging. This product is highly suitable for your normal skin type due to the presence of collagen and peptides which support collagen stimulation and boosting ECM synthesis.
- Glutathione offers antioxidant benefits, contributing to overall skin health and radiance.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/mediheal/age-r/for/oily-skin): Caution
- [Dry skin](https://lovi.care/skincare/p/mediheal/age-r/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/mediheal/age-r/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/p/mediheal/age-r/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/mediheal/age-r/for/acne-prone-skin): Low
- [Skin with dark spots](https://lovi.care/skincare/p/mediheal/age-r/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/p/mediheal/age-r/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/mediheal/age-r/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/mediheal/age-r/for/oily-acne-prone-skin): Caution

## Key ingredients

Glutathione, Collagen, Peptides

## What the research says

- Both oral and topical collagen supplements help delay the skin aging process by improving moisture, elasticity, and hydration, with no differences arising between the two types of collagen. ([Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/))
- The use of cosmetic products containing collagen or its peptides improves the general condition of the skin, reduces wrinkle depth, improves hydration and density, reduces transepithelial water loss, and delays the aging process, while oral bioactive collagen peptides also reduce nail breakage. ([Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation. ([American Journal of Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/15862509/))
- Combining high-intensity focused ultrasound with a topical agent containing glutathione and hyaluronic acid significantly improves skin quality, fine wrinkles, hyperpigmentation, hydration, and brightness in female volunteers compared to the topical agent alone. ([The Journal of Dermatological Treatment, 2024](https://pubmed.ncbi.nlm.nih.gov/39326871/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))

## What reviewers say

Based on a very large amount of data, users frequently achieve a 'glass skin' appearance and improved facial contouring, with many reporting enhanced product absorption and a more radiant complexion. While effective for dullness and mild sagging, results are highly dependent on consistent daily use, which some users find difficult to maintain. The device is also noted for improving skin texture and reducing pore visibility.

- Liked: Enhanced absorption (mostly mentioned)
- Liked: Glass skin glow (often mentioned)
- Disliked: Time-consuming routine (often mentioned)
- Liked: Improved texture (sometimes noted)
- Liked: Visible lifting (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Unpleasant sensation (sometimes noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Mediheal AGE-R work for mature skin?

Mediheal AGE-R works reasonably well for mature skin, offering moderate benefits for wrinkles and fine lines while keeping skin safe and calm without irritation. To fit this skin type even better, a product needs exceptionally high effectiveness against aging with potent antioxidants, deep hydration, and skin-repairing ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/)

### Which ingredients make this cream a good fit for mature skin?

Collagen and peptides make this treatment a good fit by supporting firmness and helping reduce the look of fine lines, while glutathione provides antioxidant benefits for overall skin health. To work best for mature skin, a product of this type needs high concentrations of potent antioxidants, deeply hydrating components, and skin-repairing ingredients that target wrinkles exceptionally well.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/)

### What does Glutathione do for mature skin?

Glutathione helps mature skin by improving moisture, smoothness, and elasticity while reducing wrinkles and age spots. It also protects skin cells from everyday oxidative stress and environmental damage with a very safe profile.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [Molecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41900080/)

### What does Collagen do for mature skin?

Collagen helps smooth mature skin by reducing wrinkles, improving hydration, and keeping the skin firm and plump. It is a weak fit for your skin, so a product of this type needs added hyaluronic acid, antioxidants, and peptides to properly nourish and support aging skin.
Sources: [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/), [Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/)

### Where does it go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing. Mature skin needs a product that uses ingredients like collagen, peptides, and antioxidants to smooth fine lines and support elasticity while keeping the skin safe from irritation.

### Can I use this cream with retinol, and in what order?

You can use this treatment with retinol by applying your retinol first and following with this cream, or by alternating the nights you use each product to keep your skin calm and comfortable. This product has a very safe profile and is unlikely to cause irritation, but mature skin also needs ingredients like retinoids or intensive firming peptides to provide better anti-aging results.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/)

### How often should I use it?

You can use this treatment in your evening routine, applying it once a day or a few times a week as your skin adjusts. Mature skin often needs a routine that combines antioxidants like glutathione with collagen-boosting ingredients and peptides to improve firmness and smooth out fine lines.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin since it has an excellent safety profile without harsh ingredients. However, a product for this skin needs rich moisturizers and barrier-supporting ingredients to keep mature skin feeling soft and smooth.
Sources: [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/), [Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/)

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — $53.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — $39.99 at Amazon
- [Drunk Elephant A-Passioni Retinol Cream](https://lovi.care/skincare/p/drunk-elephant/a-passioni-retinol-cream/for/mature-skin) — High fit — $76.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Glutathione, Collagen, Peptides
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mediheal/age-r/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/mediheal/age-r/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/mediheal/age-r/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/mediheal/age-r/for/mature-skin
- France: https://lovi.care/skincare/fr/p/mediheal/age-r/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/mediheal/age-r/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/mediheal/age-r/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/mediheal/age-r/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/mediheal/age-r/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/mediheal/age-r/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/mediheal/age-r/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/mediheal/age-r/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/mediheal/age-r/for/mature-skin