# Medicube One Day Exosome Shot 7500 for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Medicube](https://lovi.care/skincare/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- This product offers moderate exfoliation and pore-refining effects suitable for your oily skin, with Lactobacillus Extracellular Vesicles and Niacinamide improving texture and tone.
- It provides general hydration and supportive benefits for acne, blemishes, and breakouts, addressing oiliness with mild exfoliating and seboregulating properties.
- The formula is generally safe for your skin, though Betaine Salicylate and Citric Acid may pose a slight risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/medicube/one-day-exosome-shot-7500/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/medicube/one-day-exosome-shot-7500/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/medicube/one-day-exosome-shot-7500/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/medicube/one-day-exosome-shot-7500/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/medicube/one-day-exosome-shot-7500/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/medicube/one-day-exosome-shot-7500/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/medicube/one-day-exosome-shot-7500/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Lactobacillus Extracellular Vesicles, Niacinamide, Adenosine, Betaine Salicylate, Oenothera Biennis Flower Extract

## What the research says

- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport. ([Biomaterials Advances, 2022](https://pubmed.ncbi.nlm.nih.gov/35929319/))
- A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides. ([Medicina Cutanea Ibero-latino-americana, 1986](https://pubmed.ncbi.nlm.nih.gov/3528709/))
- Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models. ([Metabolites, 2021](https://pubmed.ncbi.nlm.nih.gov/34436468/))

## What reviewers say

Users frequently report a "glass skin" effect with noticeable improvements in skin texture and pore size after overnight use, though the application involves a distinct prickly sensation due to the spicules. While highly effective for smoothing and tightening, it is polarizing due to the "needle-like" pain and potential for irritation on sensitive skin.

- Liked: Smoother skin texture (mostly mentioned)
- Disliked: Painful application (mostly mentioned)
- Liked: Fast/overnight results (often mentioned)
- Liked: Visible pore reduction (often mentioned)
- Liked: Enhanced product absorption (sometimes noted)
- Disliked: Not for sensitive skin (sometimes noted)
- Disliked: Skin irritation (sometimes noted)
- Disliked: High price point (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Medicube Exosome Shot 7500 work for oily acne-prone skin?

This treatment provides moderate exfoliation and pore-refining effects for your oily skin, helping improve texture and tone while addressing breakouts and excess oiliness. The formula is generally safe, though certain exfoliating acids may pose a slight risk of irritation. A product of this type needs effective ingredients like niacinamide and soothing extracts that control oil and provide comfort without irritation, along with a balance of hydrating agents and antioxidants to support skin health.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/), [Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23545907/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Lactobacillus Extracellular Vesicles and niacinamide make this serum a fit by refining pores, smoothing texture, and helping with breakouts on oily skin. To work best for this skin, a product of this type needs soothing extracts, oil-controlling ingredients, and gentle hydrators that keep the face comfortable without heavy or breakout-causing components.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/), [Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23545907/)

### What do Lactobacillus Extracellular Vesicles do for oily acne-prone skin?

Lactobacillus extracellular vesicles help calm irritated skin and support the natural skin barrier, which is beneficial for oily acne-prone skin. These ingredients may help reduce redness and soothe breakouts while keeping the skin balanced. A product for oily acne-prone skin needs soothing ingredients and lightweight hydrators to calm flare-ups without feeling heavy.
Sources: [World Journal of Microbiology & Biotechnology, 2026](https://pubmed.ncbi.nlm.nih.gov/42804019/), [Frontiers in Immunology, 2026](https://pubmed.ncbi.nlm.nih.gov/42643438/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in your evening routine after cleansing and toning, and before your moisturizer. Oily acne-prone skin needs a well-rounded routine that includes balancing ingredients like niacinamide and gentle exfoliants to help refine pores and control breakouts without causing irritation.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this serum with retinol, and in what order?

It is best to use this treatment and a retinol on alternate nights to lower the risk of skin irritation. Because this formula contains exfoliating acids, layering both at the same time may be too harsh for your skin.

### How often should I use this serum?

Start by using this treatment once a week in the evening, and if your skin tolerates it well and you see good results, you can carefully use it more often. This product of this type needs soothing and gentle exfoliating ingredients like Lactobacillus Extracellular Vesicles and Niacinamide to refine pores and improve texture without causing too much irritation.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/), [Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23545907/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

Medicube One Day Exosome Shot 7500 helps clear pores and control oil with Betaine Salicylate, but it may cause irritation and breakouts for oily acne-prone skin due to mild exfoliating acids and active ingredients. To better fit this skin type, a product needs soothing ingredients and gentle pore-clearing agents that calm inflammation without stinging.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/), [Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23545907/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — $25.08 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — $25.08 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $21.97 (https://www.amazon.com/dp/B0D137TMRB?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Lactobacillus Extracellular Vesicles, Butylene Glycol, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Hydrolyzed Sponge, Calcium Silicate, Sodium Silicate, Sodium Polyacrylate, Hydrogenated Polydecene, Caprylyl Capryl Glucoside, C12-14 Alketh-12, Campsis Grandiflora Flower Extract, Ethylhexylglycerin, Adenosine, Disodium Edta, Panthenol, Betaine Salicylate, Citric Acid, Gluconolactone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin