# medicube Exosome Cica Calming Toner for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/medicube/exosome-cica-calming-toner/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [medicube](https://lovi.care/skincare/brands/medicube)
Category: [Toners](https://lovi.care/skincare/best/toners)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other toners fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as Centella Asiatica Extract and Heart Leaf Extract provide excellent soothing and calming effects to reduce redness and irritation.
- While these ingredients offer general soothing benefits for your acne-prone skin, the formula lacks targeted ingredients to effectively address acne, blemishes, and breakouts.
- The safety profile is good, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-toner/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-toner/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-toner/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-toner/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-toner/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/p/medicube/exosome-cica-calming-toner/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-toner/for/mature-skin): Low
- [Dry sensitive skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-toner/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-toner/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica Extract, Exosome, Heart Leaf Extract

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Adjuvant application of human adipose tissue stem cell-derived exosomes gel following fractional CO2 laser significantly improved the reduction of acne scars (32.5% vs 19.9%, p < 0.01) and reduced erythema and downtime in 25 patients compared to the control gel. ([Acta Dermato-venereologica, 2020](https://pubmed.ncbi.nlm.nih.gov/33073298/))
- Topical mesenchymal stem cell-derived exosomes reduced Ocular Surface Disease Index scores, increased tear secretion, lowered fluorescein scores, prolonged tear-film break-up time, increased Epidermal Growth Factor and thrombospondin-1, and decreased interleukin-6 and Matrix metalloproteinase-9 in patients with Sjögren's syndrome-related dry eye compared to phosphate buffered saline control. ([BMC Ophthalmology, 2025](https://pubmed.ncbi.nlm.nih.gov/40394561/))
- Topical human platelet extract exosome serum improved skin health scores and reduced redness, wrinkles, and melanin production while enhancing luminosity and color evenness at 6 weeks. ([Aesthetic Surgery Journal, 2022](https://pubmed.ncbi.nlm.nih.gov/35689936/))
- Quercetin phospholipids 1% cream significantly reduced UV-, histamine-, and chemical-induced skin erythema (-10.05%) and mean wheal diameter in 30 healthy human volunteers, showing comparable efficacy to 1% dexchlorpheniramine cream. ([Clinical, Cosmetic and Investigational Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27013898/))
- Quercetin-loaded niosomes formulated with Span60-RH40 at a 9:11 mass ratio improved quercetin solubility, photostability, sustained release, and transdermal penetration, yielding a skin retention 2.95 times higher than quercetin solution. ([Molecules, 2019](https://pubmed.ncbi.nlm.nih.gov/31238562/))
- Optimized rutin-loaded glycerosomes formulated into a nanosunscreen gel demonstrated sustained drug release, greater skin permeation, good antioxidant activity, and better epidermal retention compared to the dermis, indicating high safety, stability, and sun protection factor values for topical administration. ([Gels, 2023](https://pubmed.ncbi.nlm.nih.gov/37754433/))

## Why other toners fit acne-prone skin better

- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))

## What reviewers say

This toner is highly praised for its lightweight, watery texture that absorbs quickly without stickiness, making it suitable for oily and acne-prone skin. It is very effective at reducing redness and soothing irritation, with many users reporting improved skin balance. Some users noted concerns about the scent, price, and potential for fungal acne, though these were less common observations.

- Liked: Calms redness (mostly mentioned)
- Liked: Lightweight absorption (mostly mentioned)
- Liked: Deeply hydrating (often mentioned)
- Liked: Improves acne (sometimes noted)
- Disliked: Not fungal acne safe (rarely noted)
- Disliked: Price point (rarely noted)
- Disliked: Scent preferences (rarely noted)
- Disliked: Unclear long-term benefits (rarely noted)

## How to apply

- Use your soothing toner AM and PM daily to help keep breakouts under control.
- Apply this soothing toner right after cleansing and before your moisturizer or SPF.
- Gently press 2-3 drops of the soothing toner into your skin and let it absorb.
- Pat the soothing toner onto clean, slightly damp skin for the best absorption.
- Always do a patch test before first use and avoid getting the soothing toner in your eyes.
- Video: https://storage.pora.ai/25abe7eb181ba53153fd15de2058c2a9.mp4

## Questions and answers

### How well does medicube Exosome Cica Calming Toner work for acne-prone skin?

This toner works moderately well for acne-prone skin because Centella Asiatica Extract and Heart Leaf Extract help calm redness and irritation. However, the formula lacks targeted ingredients to actively clear breakouts. To work best for this skin, a product of this type needs effective ingredients that fight acne and blemishes while keeping skin calm.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Which ingredients make this toner a good fit for acne-prone skin?

Centella Asiatica Extract and Heart Leaf Extract make this toner a good fit by providing calming effects that help reduce redness and irritation on acne-prone skin. Because it lacks targeted ingredients to address breakouts directly, a soothing toner for this skin needs added ingredients that tackle blemishes along with gentle calming extracts.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### What does Centella Asiatica Extract do for acne-prone skin?

Centella asiatica extract helps calm angry skin, reduces redness, and supports healing for breakouts. It is unlikely to cause irritation and may improve overall skin clarity when used consistently.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/)

### What do Exosomes do for acne-prone skin?

Exosomes help calm acne-prone skin by reducing inflammation and supporting healing from breakouts and marks. They are unlikely to cause major issues when used properly, though proper application method matters to avoid unwanted reactions.
Sources: [FASEB Journal, 2026](https://pubmed.ncbi.nlm.nih.gov/41474360/), [The Journal of Craniofacial Surgery, 2025](https://pubmed.ncbi.nlm.nih.gov/40257450/)

### Where does it go in a skincare routine for acne-prone skin?

This soothing toner goes after cleansing in your routine, helping calm redness and irritation with Centella Asiatica and heart leaf extract. Because it lacks targeted acne-fighting ingredients, an acne-prone routine also needs specialized treatments with active ingredients to properly address blemishes and breakouts.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Can I use this toner with retinol, and in what order?

You can use this toner with retinol by applying the toner first to calm your skin and then following with your retinol treatment. This toner helps soothe redness and irritation, and an average-fit product for acne-prone skin needs targeted blemish-fighting ingredients to effectively clear breakouts.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### How often should I use it?

You can use this soothing toner daily as part of your morning and evening routine, since it is very gentle on the skin. Centella Asiatica Extract and Heart Leaf Extract help calm irritation, though acne-prone skin needs targeted blemish-fighting ingredients to clear breakouts.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Can this toner clog pores, cause breakouts or purging for acne-prone skin?

This toner is unlikely to clog pores or cause irritation because it contains gentle, soothing ingredients with a good safety profile. However, since it lacks targeted blemish-fighting ingredients, an acne-prone skin type needs a routine that includes acne-clearing actives like salicylic acid or benzoyl peroxide to effectively manage breakouts.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

## Alternatives for acne-prone skin

- [Medicube Super Cica Pad](https://lovi.care/skincare/p/medicube/super-cica-pad/for/acne-prone-skin) — Superior fit — $18.90 at Amazon
- [Susanne Kaufmann Tonic Soothing](https://lovi.care/skincare/p/susanne-kaufmann/tonic-soothing/for/acne-prone-skin) — High fit — $35.27 at Amazon
- [iUnik Tea Tree Relief Toner](https://lovi.care/skincare/p/iunik/tea-tree-relief-toner/for/acne-prone-skin) — High fit — $14.17 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — $15.97 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — $15.50 at Amazon
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/p/d-alba/piedmont-waterfull-mild-sunscreen/for/acne-prone-skin) — Superior fit — $15.99 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Centella Asiatica Extract, Exosome, Heart Leaf Extract, Extract Tree, Glycerin, Butylene Glycol, Water
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/exosome-cica-calming-toner/for/acne-prone-skin (this page)
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