# Medicube EXOSOME CICA CALMING PAD for mature skin

**Lovi Fit: Low fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/medicube/exosome-cica-calming-pad/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Medicube](https://lovi.care/skincare/brands/medicube)
Category: [Toners](https://lovi.care/skincare/best/toners)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A weak match for mature skin; the toners alongside fit it better.

## Why this fit

- Offers moderate soothing and calming for your normal skin, as exosome cica and niacinamide help reduce redness and irritation, though they provide general soothing benefits rather than targeted anti-aging effects for your wrinkles and fine lines.
- Niacinamide supports your skin barrier and offers anti-inflammatory action, while exosome cica provides soothing properties, making the formula highly suitable for your normal skin type.
- The product has a good safety profile with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-pad/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-pad/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-pad/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-pad/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/medicube/exosome-cica-calming-pad/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-pad/for/mature-skin): Low (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-pad/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin): Average

## Key ingredients

Exosome Cica, Tree, Niacinamide

## What the research says

- Combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling significantly improved skin wrinkles, elasticity, hydration, and pigmentation compared to microneedling alone in twenty-eight individuals with facial skin aging. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37377400/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Dermocosmetic loaded with plant extract significantly improved skin texture and surface parameters including roughness, scaliness, smoothness, and wrinkles compared to a base without extract in Asian male volunteers over three months. ([Pakistan Journal of Pharmaceutical Sciences, 2020](https://pubmed.ncbi.nlm.nih.gov/32276894/))
- A cosmetic cream containing Harungana madagascariensis plant extract induces similar anti-aging effects to a retinol-containing cream on 46 human subjects, improving wrinkles, ptosis, color homogeneity, smoothness, plumpness, firmness, and elasticity. ([Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37155516/))
- An OTC topical formulation containing a plant extract complex improved skin extensibility and firmness significantly (P < 0.02) compared to placebo in 20 volunteers, with no adverse reactions. ([International Journal of Cosmetic Science, 2000](https://pubmed.ncbi.nlm.nih.gov/18503475/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))

## Why other toners fit mature skin better

- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))

## What reviewers say

Based on a very large amount of data, users with sensitive and acne-prone skin frequently praise these pads for their immediate cooling and redness-reducing effects, often noting significant relief from facial heat and irritation. While most find them highly hydrating and effective for smoothing skin texture, a minority of users felt they were less effective for active blemishes or found the pad material slightly rough.

- Liked: Rapid soothing cooling (mostly mentioned)
- Liked: Hydrating non-sticky (often mentioned)
- Liked: Generous essence (sometimes noted)
- Liked: Gentle exfoliation (sometimes noted)
- Liked: High adherence (sometimes noted)
- Disliked: High price point (rarely noted)
- Disliked: Ineffective on acne (rarely noted)
- Disliked: Pad texture rough (rarely noted)
- Disliked: Strong scent (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using it 3 times a week and move to daily use if your skin tolerates it well.
- Apply this soothing toner right after cleansing and before your moisturizer or SPF .
- Gently press 2-3 drops of the soothing toner into your skin and let it absorb for a minute.
- Apply the soothing toner on slightly damp skin to help with better absorption.
- Avoid the sensitive eye area and do a patch test before your very first use .
- Video: https://storage.pora.ai/25abe7eb181ba53153fd15de2058c2a9.mp4

## Questions and answers

### Why is medicube Exosome Cica Calming Pad a weak match for mature skin?

This soothing toner is a weak match because it offers general calming rather than targeted anti-aging effects for your wrinkles and fine lines. A product of this type needs effective soothing ingredients that provide excellent benefits for addressing wrinkles and fine lines without any risk of irritation.

### Which ingredients make this toner a poor fit for mature skin?

This toner is a weak match for mature skin because its ingredients offer general soothing rather than targeted anti-aging effects for wrinkles and fine lines. A soothing toner for mature skin needs effective anti-aging and firming ingredients that smooth lines and boost elasticity while keeping the skin calm.

### What do Exosomes do for mature skin?

Exosomes help mature skin by improving firmness, smoothing out wrinkles, and boosting hydration. They also help calm redness and even out skin tone to give you a more glowing look.
Sources: [Dermatology Practical & Conceptual, 2026](https://pubmed.ncbi.nlm.nih.gov/41912205/), [Aesthetic Surgery Journal, 2022](https://pubmed.ncbi.nlm.nih.gov/35689936/)

### What does Tea Tree Oil do for mature skin?

Tea tree oil helps calm redness and protects mature skin from everyday stress that causes signs of aging. It may also help keep skin clear and smooth by lowering inflammation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38213091/), [International Journal of Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/22998411/)

### Where does this toner go in a skincare routine for mature skin?

This toner fits into the morning routine after your cleanser and before your moisturizer, and in the evening routine after your makeup remover and cleanser. While it helps calm and soothe the skin, this type of product needs added firming peptides and antioxidants to properly target fine lines and wrinkles on mature skin.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this toner with retinol, and in what order?

You can use this toner in your routine before applying your retinol treatment to help calm the skin. Mature skin needs products that provide targeted anti-aging ingredients like peptides, retinoids, or antioxidants to help smooth wrinkles and fine lines.

### How often should I use this toner?

This soothing toner is a weak match for mature skin because it offers general calming rather than targeted anti-aging care for wrinkles and fine lines. A toner of this type needs firming peptides, retinoids, or potent antioxidants to smooth and support mature skin.

### Can this toner clog pores, cause breakouts or purging for mature skin?

This toner is unlikely to clog pores or cause breakouts for mature skin, as it has a safe formula without harsh ingredients. A product of this type needs firming ingredients and antioxidants to better care for wrinkles and fine lines on mature skin.

## Alternatives for mature skin

- [Medicube Super Cica Pad](https://lovi.care/skincare/p/medicube/super-cica-pad/for/mature-skin) — Superior fit — $18.90 at Amazon
- [Dr. Jart+ Cicapair Toner](https://lovi.care/skincare/p/dr-jart/cicapair-toner/for/mature-skin) — High fit — $35.00 at Amazon

## Routine for mature skin

### AM

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — $46.00 at Amazon

### PM

- Pre-Cleanser: [Dermalogica PreCleanse](https://lovi.care/skincare/p/dermalogica/precleanse/for/mature-skin) — Superior fit — $49.00 at Amazon
- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Cleansing Toner: [Pixi Glow Tonic](https://lovi.care/skincare/p/pixi/glow-tonic/for/mature-skin) — Superior fit — $28.42 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/p/peach-and-lily/glass-skin-refining-serum/for/mature-skin) — Superior fit — $39.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon

### Weekly

- Pre-Cleanser: [Dermalogica PreCleanse](https://lovi.care/skincare/p/dermalogica/precleanse/for/mature-skin) — Superior fit — $49.00 at Amazon
- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Enzyme Powder: [Fancl Facial Washing Powder](https://lovi.care/skincare/p/fancl/facial-washing-powder/for/mature-skin) — Superior fit — $22.00 at Amazon
- Nourishing Mask: [MEDIHEAL Vita Essential Mask](https://lovi.care/skincare/p/mediheal/vita-essential-mask/for/mature-skin) — Superior fit — $22.00 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/p/peach-and-lily/glass-skin-refining-serum/for/mature-skin) — Superior fit — $39.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Exosome Cica, Tree, Niacinamide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/exosome-cica-calming-pad/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/exosome-cica-calming-pad/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/exosome-cica-calming-pad/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-pad/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medicube/exosome-cica-calming-pad/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-pad/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-pad/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medicube/exosome-cica-calming-pad/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-pad/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/medicube/exosome-cica-calming-pad/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/exosome-cica-calming-pad/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/exosome-cica-calming-pad/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/exosome-cica-calming-pad/for/mature-skin