# MARY & MAY 6 Peptide Complex Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [MARY & MAY](https://lovi.care/skincare/brands/mary-and-may)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Highly suitable for your combination skin due to the presence of multiple peptides like Copper Tripeptide-1 and Hexapeptide-11, which support collagen synthesis and skin repair, offering moderate plumping and firming benefits.
- While the serum provides general skincare benefits like hydration and soothing, it lacks targeted ingredients to address your oily shine.
- The formula is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Copper Tripeptide-1, Hexapeptide-11, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1

## What the research says

- Hexapeptide-11 activated proteasome, autophagy, chaperones, and antioxidant response genes, protected fibroblasts against oxidative-stress-mediated premature cellular senescence, and improved skin elasticity in human subjects. ([Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/))
- Treatment with Jet-M and GHR formulation greatly decreased wrinkles around the eye and increased collagen production in a 59-year-old male. ([Journal of Cosmetic and Laser Therapy, 2016](https://pubmed.ncbi.nlm.nih.gov/27064823/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Hexapeptide-11 reversibly downregulated ATM and p53 protein expression in intrinsically aged fibroblasts, extrinsically aged fibroblasts, and extrinsically aged dermal papillae cells at concentrations between 0.1% and 1.0% in vitro, thereby influencing the onset of cellular senescence. ([Journal of Cosmetic Science, 2013](https://pubmed.ncbi.nlm.nih.gov/23578831/))
- Topical treatment with cyclized hexapeptide-9 significantly reduced wrinkles and roughness in crow's feet and forehead compared to vehicle, and generally outperformed retinol in healthy volunteers with aging skin. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/))
- A chemically synthesized homotrimeric collagen peptide exhibited high purity, a stable triple-helical conformation, and excellent thermal stability, while safely enhancing collagen and elastin synthesis in fibroblasts in vitro and increasing skin collagen content, improving skin structure, and enhancing microvessel density in BALB/c mice in vivo. ([Frontiers in Bioengineering and Biotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40357327/))
- The addition of soybean peptide and collagen peptide to normal human dermal fibroblasts increased collagen synthesis and gene expression related to collagen formation, with the highest collagen levels observed when both peptides were added together compared to individual additions. ([International Journal of Food Sciences and Nutrition, 2012](https://pubmed.ncbi.nlm.nih.gov/22264122/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Based on a very large amount of data, users with diverse skin types consistently praise this serum for its lightweight hydration and ability to plump the skin without irritation. While it is not a miracle cure for deep wrinkles, the majority of users report smoother skin texture, improved elasticity, and a reduction in fine lines after consistent use.

- Liked: Lightweight & fast-absorbing (mostly mentioned)
- Liked: Gentle & non-irritating (often mentioned)
- Liked: Hydrating & plumping (often mentioned)
- Liked: Good value (sometimes noted)
- Disliked: Subtle or slow results (sometimes noted)
- Disliked: Consumed quickly (rarely noted)
- Disliked: Rare skin reactions (rarely noted)
- Disliked: Texture too watery (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Mary & May 6 Peptide Complex Serum work for combination skin?

Mary & May 6 Peptide Complex Serum works well enough for your combination skin by giving you light hydration and firming benefits with its mix of peptides, though it lacks ingredients to manage your oily shine. A treatment for combination skin needs balancing ingredients like niacinamide and zinc PCA to control excess oil while keeping your skin hydrated and smooth.
Sources: [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/)

### Which ingredients make this serum a good fit for combination skin?

This serum fits combination skin well through helpful peptides like Copper Tripeptide-1 and Hexapeptide-11, which support collagen and skin repair to give you moderate firming. However, a treatment of this type needs ingredients like niacinamide and zinc PCA to properly manage oily shine.
Sources: [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/)

### What does Copper Tripeptide-1 do for combination skin?

Copper Tripeptide-1 helps calm combination skin, smooth fine lines, and support a strong skin barrier. It protects against sun damage and helps tighten the skin, keeping it looking firm and healthy.
Sources: [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/), [BioMed Research International, 2015](https://pubmed.ncbi.nlm.nih.gov/26236730/)

### What does Hexapeptide-11 do for combination skin?

Hexapeptide-11 helps improve skin elasticity and protects your skin against oxidative stress. For a good fit on combination skin, this type of product needs hydrating ingredients that balance oily and dry areas without clogging pores.
Sources: [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/)

### Where does this serum go in a skincare routine for combination skin?

This treatment serum goes in your evening routine after cleansing and toning, and before moisturizing. Combination skin of this type also needs targeted ingredients to control oily shine.

### Can I use it with retinol, and in what order?

You can use this treatment with retinol by applying the retinol first and following with this serum, or by using them on alternating nights to keep your skin calm. The formula is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

### How often should I use this serum?

You can use this serum in your evening routine, applying it carefully as a treatment step. To properly care for combination skin, this type of product also needs ingredients that balance oily shine.
Sources: [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/)

### Can it clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts for combination skin because its gentle formula is safe and free of harsh ingredients. However, it lacks targeted ingredients to control oily shine, so this skin type also needs oil-balancing ingredients and lightweight hydrators.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — $28.88 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — $200.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $19.44 (https://www.amazon.com/dp/B095YHYF33?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Glycereth-26, 1,2-Hexanediol, Butylene Glycol, Glycerin, Arginine, Carbomer, Ethylhexylglycerin, Polyglyceryl-10 Laurate, Adenosine, Caprylyl Glycol, Copper Tripeptide-1, Hexapeptide-11, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Tripeptide-1
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/combination-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/mary-and-may/6-peptide-complex-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/mary-and-may/6-peptide-complex-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/mary-and-may/6-peptide-complex-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/mary-and-may/6-peptide-complex-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/mary-and-may/6-peptide-complex-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/mary-and-may/6-peptide-complex-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/mary-and-may/6-peptide-complex-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/mary-and-may/6-peptide-complex-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/mary-and-may/6-peptide-complex-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/mary-and-may/6-peptide-complex-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/mary-and-may/6-peptide-complex-serum/for/combination-skin