Mario Badescu Enzyme Cleansing Gel for oily acne-prone skin

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Questions and answers

What the research says

• A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face.

  Giornale Italiano Di Dermatologia E Venereologia, 2015

• Incorporating 1, 2, and 5 percent papain into starch- and carboxymethyl cellulose-based films preserved proteolytic and skin exfoliation activity while improving mechanical properties and water solubility compared to control films, with immobilized enzyme maintaining stability for up to 90 days.

  International Journal of Biological Macromolecules, 2023

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo.

  Wilderness & Environmental Medicine, 2016

• Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation.

  Molecules, 2020

• Carica papaya leaf extracts obtained via supercritical fluid and conventional methods demonstrated antioxidant and cytoprotective effects on skin fibroblasts against oxidative stress, driven by their respective lipophilic and hydrophilic constituents.

  Molecules, 2021

• Topical application of an aqueous gel containing 0.1% w/w naringenin demonstrated in vitro safety, significantly reduced UV-induced stratum corneum lipid peroxidation, and showed in vivo anti-inflammatory efficacy against methyl nicotinate-induced inflammation in human participants compared to a blank gel and untreated area, while chlorogenic acid, apigenin, and kaempferol displayed pro-oxidant profiles.

  Frontiers in Chemistry, 2024

• Topical application of a naringenin-containing formulation protected hairless mice from ultraviolet B-induced skin damage by inhibiting edema, cytokine production, superoxide anion, and lipid hydroperoxides while maintaining antioxidant enzymes and glutathione levels.

  PloS One, 2016

• Encapsulating naringenin, nordihydroguaiaretic acid (NDGA), and kaempferol into nanostructured lipid carriers provided prolonged release, stability, and antioxidant protection against oxidative stress in human keratinocytes, with an NDGA and kaempferol mixture showing synergistic antioxidant effects.

  Pharmaceutics, 2021

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• Topical 2% tea lotion significantly decreased inflammatory lesions and was superior to 5% zinc sulphate solution in patients with acne vulgaris.

  Saudi Medical Journal, 2008

• Topical 2% tea lotion significantly reduced the mean lesion count of papules and pustules in patients with mild to moderate acne vulgaris compared to a control solution over 2 months.

  Saudi Medical Journal, 2006

Ingredients

Glycerin, Propylene Glycol, Peg-8 Stearate, Ppg-2 Hydroxyethyl Cocamide, Carica Papaya Fruit Extract, Grapefruit Fruit Extract, Carbomer, Sodium Chloride, Parfum, Phenoxyethanol, Methylparaben, Propylparaben, Triethanolamine, Diazolidinyl Urea, Mica, Ci 77891 Titanium Dioxide, Ci 19140 Yellow 5, Ci 42090 Blue 1, Ci 15985, Linalool, Hexyl Cinnamal, Benzyl Alcohol, Limonene, Citronellol, Geraniol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.