# Manyo Factory Bifida Biome Complex Ampoule for dry skin

**Lovi Fit: Superior fit for dry skin.**
Dry Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Manyo Factory](https://lovi.care/skincare/brands/manyo-factory)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for dry skin.

## Why this fit

- Excellent suitability for your dry skin is provided by Bifida Lysate Ferment and multiple forms of Hyaluronic Acid, which deeply hydrate and support your skin barrier. Glycerin and Squalane further enhance humectant and emollient actions, leaving your skin smoother and more radiant.
- The combination of Lactobacillus Lysate Ferment and Lactococcus Lysate Ferment strengthens your skin barrier resilience, complementing the hydration benefits.
- This formula is safe for your dry skin, as it contains no harsh ingredients and includes soothing components like Bifida Lysate Ferment and Glycerin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin): Superior (this page)
- [Combination skin](https://lovi.care/skincare/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/manyo-factory/bifida-biome-complex-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/manyo-factory/bifida-biome-complex-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/manyo-factory/bifida-biome-complex-ampoule/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Bifida Lysate Ferment, Niacinamide, Copper Tripeptide-1, Sodium Hyaluronate, Acetyl Hexapeptide-8

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))

## What reviewers say

Based on a very large amount of data, users widely praise this ampoule for its ability to strengthen the skin barrier and provide deep hydration without feeling heavy. Many report achieving a healthy, radiant glow and appreciate its lightweight, fast-absorbing texture, with some finding it soothing for redness and irritation. A small number of users experienced breakouts, and some felt the watery consistency was not moisturizing enough on its own or that the results did not justify the price.

- Liked: Strengthens barrier (mostly mentioned)
- Liked: Hydration and glow (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Soothing and calming (sometimes noted)
- Disliked: Lack of results (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Price vs. value (rarely noted)
- Disliked: Too watery (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Manyo Factory Bifida Biome Complex Ampoule one of the best fits for dry skin?

This product is an excellent fit for dry skin because it combines multiple forms of hyaluronic acid, glycerin, and squalane to deeply hydrate and smooth your skin. It also features fermented ingredients like bifida lysate ferment that help strengthen your skin barrier while keeping your routine gentle and calm.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry skin?

Bifida Lysate Ferment, multiple forms of Hyaluronic Acid, glycerin, and squalane make this serum an excellent fit by deeply hydrating and supporting your skin barrier. They help leave dry skin smoother, more radiant, and better protected against moisture loss.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Bifida Ferment Lysate do for dry skin?

Bifida Ferment Lysate helps dry skin by strengthening the skin barrier and keeping it well hydrated. It also helps calm irritation and protects against everyday stress.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Scientific Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37803101/)

### What does Niacinamide do for dry skin?

Niacinamide helps dry skin by strengthening the skin barrier, increasing hydration, and reducing water loss. It supports ceramide production and helps keep the surface smooth and calm. This ingredient tends to be very well tolerated and is unlikely to irritate dry skin.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42108609/)

### Where does it go in a skincare routine for dry skin?

This treatment is used in the evening after cleansing and before your moisturizer. Putting it at night gives you extra safety around sun exposure and keeps your routine simple.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to deeply hydrate your dry skin, followed by your retinol product. This helps support your skin barrier and is unlikely to cause irritation since the formula contains soothing ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use it?

Use this treatment in your evening routine, applying it after cleansing and before your moisturizer. It is safe for daily use on dry skin, helping to deeply hydrate and support your skin barrier without harsh ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores or cause breakouts on dry skin, as it contains no harsh ingredients and is well-suited for your skin type. Reviewers rarely mention breakouts, and soothing components help keep your skin calm.

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — $16.75 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — $53.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — $19.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — $19.99 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — $16.99 at Amazon
- Moisturizer: [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/dry-skin) — Superior fit — $22.00 at Amazon

## Where to buy

- Amazon.com: $19.90 (https://www.amazon.com/dp/B08RYMSLPG?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Bifida Lysate Ferment, Butylene Glycol, Bifida Ferment Filtrate, Lactobacillus Lysate Ferment, Lactococcus Lysate Ferment, Saccharomyces Ferment Filtrate, Glycerin, Niacinamide, 1,2-Hexanediol, Lactobacillus Pumpkin Fruit Ferment Filtrate, Aureobasidium Pullulans Ferment, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Hydrolyzed Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Leontopodium Alpinum Callus Culture Extract, Cutibacterium Granulosum Extract Ferment Filtrate, Asiaticoside, Asiatic Acid, Madecassic Acid, Pentylene Glycol, Squalane, Hydrogenated Lecithin, Copper Tripeptide-1, Tromethamine, Acetyl Hexapeptide-8, Propanediol, Ethylhexylglycerin, Dextrin, Water, Caffeine, Benzyl Glycol, Sodium Phytate, Hydrolyzed Algin, Xanthan Gum, Epigallocatechin Gallate, Carbomer, Physalis Alkekengi Calyx Extract, Hydrolyzed Glycosaminoglycans, Polyglyceryl-10 Laurate, Theobroma Cacao Seed Extract, Adenosine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin
- France: https://lovi.care/skincare/fr/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin