# ma:nyo Bifida Complex Ampoule for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: Average · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/p/ma-nyo/bifida-complex-ampoule/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [ma:nyo](https://lovi.care/skincare/brands/ma-nyo)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers excellent skin barrier resilience due to Bifida Lysate Ferment and Lactobacillus Pumpkin Fruit Ferment Filtrate, which are beneficial for your oily skin, but it lacks targeted ingredients to effectively address your acne, blemishes, and breakouts.
- Niacinamide provides some seboregulation for your oily skin, but the formula does not offer sufficient ingredients for optimal oil control.
- The product is generally safe for your oily skin with some risks of irritation due to the absence of harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/ma-nyo/bifida-complex-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/ma-nyo/bifida-complex-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/ma-nyo/bifida-complex-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/ma-nyo/bifida-complex-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/ma-nyo/bifida-complex-ampoule/for/acne-prone-skin): Low
- [Skin with dark spots](https://lovi.care/skincare/p/ma-nyo/bifida-complex-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/ma-nyo/bifida-complex-ampoule/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/ma-nyo/bifida-complex-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/ma-nyo/bifida-complex-ampoule/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Bifidobacterium Lysate Ferment Bifidalacto Complex Ferment, Niacinamide, Lactobacillus Pumpkin Fruit Ferment Filtrate, Panax Ginseng Root Extract, Sodium Hyaluronate

## What the research says

- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical treatment with pumpkin seed oil-loaded niosomes decreased fallen hairs by 44.42% and increased the anagen to telogen ratio by 1.4-fold after 8 weeks compared to initial conditions. ([Pharmaceuticals, 2022](https://pubmed.ncbi.nlm.nih.gov/36015077/))
- Topical application of prickly pear, pumpkin, and linseed oils significantly reduced clinical signs of acute inflammation, inflammatory markers, and oxidative stress in carrageenan-treated rats compared to the normal saline-treated group. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/32802857/))
- Enzyme-modified ginseng extract cream significantly reduced the global photo-damage score and various roughness measures including total roughness, smoothness depth, and arithmetic roughness average compared to placebo in 23 human subjects. ([Rejuvenation Research, 2015](https://pubmed.ncbi.nlm.nih.gov/25867599/))
- A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects. ([Journal of Ginseng Research, 2022](https://pubmed.ncbi.nlm.nih.gov/35509819/))
- A 1% fermented black ginseng cream significantly reduced eye wrinkles and brightened skin color in twenty-three human subjects compared to control cream and baseline. ([Journal of Toxicology and Environmental Health. Part A, 2020](https://pubmed.ncbi.nlm.nih.gov/32564709/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## Why other serums fit oily acne-prone skin better

- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does ma:nyo Bifida Complex Ampoule work for oily acne-prone skin?

This ampoule works okay for your oily acne-prone skin because it strengthens your skin barrier and helps with oil, but it lacks targeted ingredients to properly handle breakouts. An ideal treatment for this skin needs ingredients like niacinamide, propolis, or Vitamin C to control oil and clear blemishes comfortably without causing breakouts.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Bifida Lysate Ferment and Lactobacillus Pumpkin Fruit Ferment Filtrate help strengthen your skin barrier, while niacinamide offers some oil control for oily acne-prone skin. However, an oily acne-prone skin type needs targeted ingredients like propolis or vitamin C to effectively address breakouts and manage excess oil.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### What does Bifida Ferment Lysate do for oily acne-prone skin?

Bifida Ferment Lysate helps keep oily, acne-prone skin calm and protected by strengthening the skin barrier and lowering irritation. It is unlikely to clog pores and may reduce redness and reactivity while supporting your skin's natural defenses.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in your evening routine after your cleansing toner and before your moisturizer. Oily acne-prone skin of this type needs targeted ingredients that actively clear breakouts, blemishes, and acne alongside oil-control ingredients.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the serum first to strengthen your skin barrier, followed by retinol once it absorbs. This routine is unlikely to cause irritation since the formula is generally safe, and using soothing care alongside retinoids may help reduce dryness and discomfort.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. Oily acne-prone skin needs targeted blemish-fighting ingredients and stronger oil control to get the best results.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to cause breakouts or clog pores for oily acne-prone skin, as it is generally safe and free of harsh ingredients. However, because it lacks targeted ingredients for blemishes and strong oil control, an acne-prone routine needs added acne-fighting ingredients and oil-balancing components to truly clear the skin.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — $25.08 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — $25.08 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — $18.99 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Bifida Lysate Ferment, Lactobacillus Pumpkin Fruit Ferment Filtrate, Niacinamide, Butylene Glycol, Acetyl Hexapeptide-8, Aureobasidium Pullulans Ferment, Hydrolyzed Algin, Caffeine, Panax Ginseng Root Extract, Panax Ginseng Callus Culture Extract, Glycerin, Epigallocatechin Gallate, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Usnea Barbata Extract, Copper Tripeptide-1, Physalis Alkekengi Fruit Extract, Methyl Gluceth-20, Sodium Hyaluronate, Adenosine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/ma-nyo/bifida-complex-ampoule/for/oily-acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/ma-nyo/bifida-complex-ampoule/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/ma-nyo/bifida-complex-ampoule/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/ma-nyo/bifida-complex-ampoule/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/ma-nyo/bifida-complex-ampoule/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/ma-nyo/bifida-complex-ampoule/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/ma-nyo/bifida-complex-ampoule/for/oily-acne-prone-skin
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- Canada: https://lovi.care/skincare/ca/p/ma-nyo/bifida-complex-ampoule/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/ma-nyo/bifida-complex-ampoule/for/oily-acne-prone-skin
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