La Roche-Posay Toleriane Rosaliac AR Concentrate for dry sensitive skin

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Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Non-polar extracts of Schisandra sphenanthera and Schisandra chinensis inhibited the proliferation of HaCaT and A431 epidermal cell lines and reduced COX-2 expression and prostaglandin production, with non-polar extracts showing superior activity compared to polar ones.

  Planta Medica, 2007

• Schisandrin B protected human keratinocyte-derived HaCaT cells from tert-butyl hydroperoxide-induced oxidative damage by reducing cell death, oxidative stress, and DNA damage while enhancing antioxidant enzyme expression through the Nrf2 signaling pathway.

  International Journal of Molecular Medicine, 2018

• Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes.

  Life, 2023

• Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne.

  The Medical Journal of Malaysia, 2024

• A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro.

  International Journal of Cosmetic Science, 2025

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

• Exposure of epidermal full-thickness skin equivalents to a blend of betaine, pentylene glycol, Saccharomyces cerevisiae, and Rhodiola rosea root extract significantly increased antioxidant, skin barrier, and oxidative stress biomarkers while reducing the negative impact of hydrogen peroxide on MMP3, MMP12, FBN2, ANXA1, and HGF, whereas a blend of Narcissus tazetta bulb extract and Schisandra chinensis fruit extract significantly increased 8 growth factors, 7 signaling, 7 structural/barrier function, 7 oxidative stress biomarkers, and specific microRNAs over control levels.

  International Journal of Molecular Sciences, 2018

• Omija essential oil obtained by supercritical fluid extraction significantly reduced UV-B-induced ROS production in HaCaT keratinocytes and inhibited NO production in lipopolysaccharide-induced RAW 264.7 macrophages by suppressing iNOS expression and the NF-kappaB pathway.

  Foods, 2021

• An injectable, self-healing, and superadhesive PVA hydrogel trapping Northern Schisandrin B promotes skin wound healing by continuously suppressing inflammation to manage the inflammatory microenvironment.

  ACS Applied Bio Materials, 2025

Ingredients

Water, Glycerin, Isostearyl Neopentanoate, Butylene Glycol, Boron Nitride, Butyrospermum Parkii Butter, Shea Butter, Ci 77891, Titanium Dioxide, Pentylene Glycol, Hydrogenated Coco-Glycerides, Polysorbate 20, Zea Mays Starch, Schisandra Sphenanthera Fruit Extract, Tin Oxide, Sorbitan Oleate, Glyceryl Acrylate Acrylic Acid Copolymer, Glyceryl Stearate Citrate, Isohexadecane, Sphingomonas Extract Ferment, Silica, Aluminum Hydroxide, Mannitol, Ammonium Polyacryloyldimethyl Taurate, Hydrogenated Lecithin, Caprylyl Glycol, Citric Acid, Trisodium Ethylenediamine Disuccinate, Acetyl Dipeptide-1 Cetyl Ester, Maltodextrin, Polysorbate 80, Acrylamide Sodiumacryloyldimethyltaurate Copolymer, Mica, Ci 77288, Ci 77491, Iron Oxides, Ci 77492, Ci 77499, N70017620 1

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.