# La Roche-Posay Toleriane Dermallergo Night for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [La Roche-Posay](https://lovi.care/skincare/brands/la-roche-posay)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as squalane and glycerin provide excellent moisturization and barrier support beneficial for oily shine.
- Niacinamide offers additional soothing benefits, though it may not fully address the specific needs of both oily and dry areas of your combination skin.
- The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night/for/oily-acne-prone-skin): High

## Key ingredients

Thermal Spring Water, Squalane, Niacinamide, Butyrospermum Parkii Shea Butter, Dimethicone

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39528438/))
- Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups. ([Military Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38771104/))
- A dimethicone skin protectant lotion significantly decreased visual scoring and transepidermal water loss compared to vehicle control and SLS-only treated sites in 12 healthy humans exposed to sodium lauryl sulfate. ([Skin Research and Technology, 2000](https://pubmed.ncbi.nlm.nih.gov/11428946/))
- Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms. ([Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/))

## What reviewers say

Users frequently report waking up to softer, plumper, and less irritated skin. A minority of users with oily or acne-prone skin found the formula too heavy or experienced breakouts.

- Liked: Soothes sensitive skin (mostly mentioned)
- Liked: Deeply hydrating (often mentioned)
- Liked: Lightweight texture (sometimes noted)
- Disliked: Causes breakouts (rarely noted)
- Disliked: Not hydrating enough (rarely noted)
- Disliked: Sticky or heavy (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Toleriane Dermallergo Night work for combination skin?

This moisturizer works moderately well for your combination skin because squalane and glycerin provide balanced moisture and barrier support that helps with oily shine, though it may not fully address every need of both oily and dry areas. It is completely safe and unlikely to cause irritation, but a product for this skin type needs targeted brightening and hydrating ingredients along with antioxidants to manage multiple concerns and keep the skin balanced without excess weight.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for combination skin?

Squalane and glycerin help make this cream a good fit by providing balanced moisturization and barrier support for your skin. To work best for combination skin, a product of this type needs targeted hydrating and brightening ingredients along with soothing agents to address both oily and dry areas effectively.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Thermal Spring Water do for combination skin?

Thermal spring water helps calm sensitive areas, adds light hydration to dry spots, and keeps combination skin feeling comfortable. It is unlikely to clog pores and may reduce redness or stinging while supporting overall skin balance.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2020](https://pubmed.ncbi.nlm.nih.gov/32870553/), [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/)

### What does Squalane do for combination skin?

Squalane helps keep combination skin soft and smooth by locking in moisture without feeling heavy or greasy. It supports the skin barrier and provides lightweight hydration that works well for both dry and oily areas.
Sources: [Skin Health and Disease, 2024](https://pubmed.ncbi.nlm.nih.gov/39355739/), [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/)

### Where does this cream go in a skincare routine for combination skin?

This cream goes as the moisturizer step in both your morning and evening routines. For combination skin, a product of this type needs balanced hydration and soothing ingredients like glycerin and niacinamide to keep both oily and dry areas comfortable.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this cream with retinol, and in what order?

Yes, you can use this cream with retinol by applying it before or after retinol to help keep your skin comfortable and support its barrier. Using a barrier-supporting moisturizer alongside retinol helps reduce dryness and irritation while improving how your skin handles the treatment.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [The Journal of Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24930436/)

### How often should I use this cream?

You can use this moisturizing cream daily as part of your morning and evening skincare routine. Regular application helps keep skin soft and supports your skin barrier, though combination skin also needs targeted care to properly balance both oily and dry areas.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/)

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to clog pores or cause breakouts on your combination skin, as it has a very safe formula with no harsh ingredients. However, because it is a rich moisturizer, a product of this type for combination skin needs to balance deep hydration with lightweight, oil-controlling ingredients so it feels smooth without sitting heavily on oily areas.

### Can I use this cream around the eyes or on my body?

You can use this cream on the thin skin around your eyes and on your body, though it is primarily formulated for the face. The safety profile of its ingredients is gentle, and your skin is unlikely to experience irritation. However, because skin thickness and needs vary greatly across body regions, this type of product works best when it balances lightweight hydration for sensitive areas with richer nourishment for drier zones.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/combination-skin) — Superior fit — $15.50 at Amazon
- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin) — Superior fit — $49.95 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/p/the-ordinary/natural-moisturizing-factors-ha/for/combination-skin) — High fit — $12.50 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — $25.60 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — $14.97 at Amazon

## Where to buy

- Amazon.com: $31.97 (https://www.amazon.com/dp/B01D2SVADM?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Squalane, Butyrospermum Parkii Shea Butter, Glycerin, Dimethicone, Pentylene Glycol, Niacinamide, Sodium Hydroxide, Tocopherol, Adenosine, Caprylyl Glycol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Citric Acid, Disodium Edta, Ethylhexylglycerin, Sodium Citrate, Xanthan Gum, Polysorbate 20
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin
- France: https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin