La Roche-Posay Anthelios AOX Daily Antioxidant Serum with Sunscreen SPF 50 for acne-prone skin

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Questions and answers

What the research says

• Topical application of tocopherol succinate ethosomal gel decreased erythema, melanin, and sebum levels while improving moisture content and skin elasticity in 34 human women.

  Journal of Cosmetic Dermatology, 2024

• A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers.

  Journal of Cosmetic Dermatology, 2020

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Encapsulating avobenzone in low-porosity TiO2-embedded mesoporous silica (TiO2/SBA-S) reduced cutaneous avobenzone absorption from 0.76 to 0.50 nmol/mg while providing effective pollutant adsorbability, UVA protection, and a two- to three-fold reduction in photoaged skin cytokines/chemokines compared to the non-treatment control.

  European Journal of Pharmaceutical Sciences, 2023

• Chemical sunscreens containing avobenzone, octocrylene, homosalate, and octisalate showed no to minimal risks of dermal irritation, sensitization, photo-allergy, and photo-irritation in human subjects.

  Journal of Drugs in Dermatology, 2025

• A nighttime topical antioxidant containing resveratrol, baicalin, and vitamin E significantly improved fine lines, wrinkles, firmness, elasticity, laxity, hyperpigmentation, radiance, roughness, and dermal thickness in subjects with mild to moderately photodamaged skin over 12 weeks.

  Journal of Drugs in Dermatology, 2014

• Motor baicalin encapsulated in bio-vesicles enhanced water solubility, stability, transdermal penetration, antioxidant activity, and clinical skin antiaging efficacy compared to liposome baicalin and baicalin raw material.

  Journal of Cosmetic Dermatology, 2025

• Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.

  Journal of Cosmetic Dermatology, 2026

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

• Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.

  Journal of Cosmetic Dermatology, 2025

• Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.

  Contemporary Clinical Trials Communications, 2021

• Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.

  Journal of Cosmetic Dermatology, 2024

• Sunscreens containing Mexoryl SX provide superior protection against UVA- and solar-simulated radiation-induced biological damage, including pigmentation, DNA damage, immune suppression, and dermal alterations, compared to formulations without it in human volunteers and patients.

  Photodermatology, Photoimmunology & Photomedicine, 2008

• Mexoryl SX (5%) efficiently prevents UVA-induced skin alterations including pigmentation, stratum corneum thickening, and protein expression changes in human skin.

  Journal of Photochemistry and Photobiology. B, Biology, 1998

• Topical application of both a UVB absorber and a broad-spectrum Mexoryl SX sunscreen effectively prevented UVB-induced damage in in vitro reconstructed human skin, whereas only the Mexoryl SX-containing preparation successfully prevented UVA-specific dermal fibroblast disappearance.

  Photochemistry and Photobiology, 2000

Ingredients

Avobenzone, Homosalate, Octisalate, Octocrylene, Oxybenzone, Water, Dimethicone, Cyclopentasiloxane, Tocopherol, Acrylates Dimethicone Copolymer, Phenoxyethanol, Propylene Glycol, Caprylyl Glycol, Silica, Sodium Polyacrylate, Ascorbyl Glucoside, Scutellaria Baicalensis Root Extract, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Disodium Edta, Diethylhexyl Syringylidenemalonate, Polyacrylamide, C13-14 Isoparaffin, Laureth-7, Cassia Alata Leaf Extract, Maltodextrin, Triethanolamine

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.