L'Oreal Paris Age Perfect Cell Renewal Midnight Cream for combination skin

How to apply

Questions and answers

What the research says

• Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

  American Journal of Clinical Dermatology, 2002

• A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

  The Journal of Dermatological Treatment, 2017

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.

  The Journal of Dermatology, 2008

• Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.

  International Journal of Molecular Sciences, 2026

• Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.

  International Journal of Molecular Sciences, 2021

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

• Capryloyl salicylic acid peel reduced fine lines, wrinkles, and hyperpigmentation comparably to glycolic acid peel in 44 female volunteers, with no statistically significant differences between the two treatments.

  Journal of Cosmetic Dermatology, 2008

• Combining a salicylic acid and lipohydroxy acid facial serum and mask improved closed comedones and acne severity significantly more than serum alone in adults with acne over 8 weeks, with no adverse reactions reported.

  Journal of Cosmetic Dermatology, 2023

• Parity was demonstrated between an OTC BPO 5.5% formulation with lipohydroxy acid and tretinoin cream 0.025% versus prescription clindamycin 1%-BPO 5% gel and tretinoin cream 0.025% in participants with mild to moderate acne vulgaris at 12 weeks.

  Cutis, 2012

• Kombucha Yerba Mate ferments after 14 and 21 days of fermentation showed about a 40% inhibition of lipoxygenase, collagenase, and elastase enzymes, long-lasting skin hydration, and increased cell viability on keratinocyte and fibroblast cell lines compared to unfermented extracts.

  Scientific Reports, 2021

• Fermentation of grape stems extract using a Scoby consortium for 10 and 20 days increases phenolic content and antioxidant activity, and when added to model cosmetic creams, improves skin hydration and reduces transepidermal water loss.

  International Journal of Cosmetic Science, 2023

Ingredients

Water, Glycerin, Hydrogenated Polyisobutene, Dimethicone, Butylene Glycol, Bis-Behenyl Isostearyl Phytosteryl Dimer Dilinoleyl Dimer Dilinoleate, Butyrospermum Parkii Butter, Shea Butter, Limnanthes Alba Seed Oil, Stearyl Alcohol, C30-45 Alkyl Dimethicone, Peg-20 Stearate, Saccharomyces Xylinum Black Tea Ferment, Panthenol, Silica, Adenosine, Capryloyl Salicylic Acid, Hydroxyacetophenone, Hydroxypropyl Tetrahydropyrantriol, Neohesperidin Dihydrochalcone, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Potassium Hydroxide, Tetrasodium Glutamate Diacetate, Tocopherol, Octyldodecanol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Ammonium Polyacryloyldimethyl Taurate, Caprylyl Glycol, Carbomer, Citric Acid, Glyceryl Stearate, Peg-100 Stearate, Peg-30 Dipolyhydroxystearate, Propylene Glycol, Trideceth-6, Alpha-Isomethyl Ionone, Benzyl Alcohol, Benzyl Salicylate, Citronellol, Geraniol, Hexyl Cinnamal, Hydroxycitronellal, Limonene, Linalool, Ci 14700, Red 4, Ci 19140, Yellow 5, Chlorphenesin, Potassium Sorbate, Sodium Benzoate, Parfum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.