# Jole Azelaic Acid 10% Serum for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/jole/azelaic-acid-10-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Jole](https://lovi.care/skincare/brands/jole)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin, this serum effectively targets oily shine and acne lesions with azelaic acid and niacinamide, which help control sebum production and reduce pore appearance.
- The inclusion of soothing ingredients like Bisabolol and Allantoin further enhances its anti-inflammatory properties, ensuring a comfortable experience for your skin.
- The product is safe for your skin, as it contains no harsh ingredients and is formulated to minimize irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/jole/azelaic-acid-10-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/jole/azelaic-acid-10-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/jole/azelaic-acid-10-serum/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/p/jole/azelaic-acid-10-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/jole/azelaic-acid-10-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/jole/azelaic-acid-10-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/jole/azelaic-acid-10-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/jole/azelaic-acid-10-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/jole/azelaic-acid-10-serum/for/oily-acne-prone-skin): High

## Key ingredients

Azelaic Acid, Niacinamide, Squalane, Bisabolol, Allantoin

## What the research says

- Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/))
- Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo. ([Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/))
- Topical administration of 20% azelaic acid cream and 5% tranexamic acid solution comparably improved acne-related postinflammatory hyperpigmentation in patients with acne vulgaris, while tranexamic acid demonstrated a significantly better safety profile at week 4. ([Journal of Research in Medical Sciences, 2023](https://pubmed.ncbi.nlm.nih.gov/37213446/))
- Azelaic acid 15% gel showed comparable efficacy to adapalene 0.1% gel in reducing lesions, severity, and Dermatology Life Quality Index in women with adult acne, with significantly lower dryness and scaling, and demonstrated superiority during maintenance compared to no further treatment. ([Journal of the European Academy of Dermatology and Venereology, 2015](https://pubmed.ncbi.nlm.nih.gov/25399481/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Application of an alpha-bisabolol-containing cream produced a significant skin-lightening effect in pigmented skin compared to a vehicle control in the majority of female subjects after 8 weeks. ([International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/20642768/))
- The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate reduces UVB-induced PGE2, inflammatory cytokines, and mitochondrial superoxide in human epidermal keratinocytes. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38433250/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Prophylactic application of a topical scar gel containing Allium cepae extract, allantoin, and heparin significantly improves patient-assessed scar color, stiffness, and irregularity compared to no treatment in women following a cesarean section. ([Journal of Drugs in Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24509969/))

## What reviewers say

Users highly recommend this serum for acne-prone and sensitive skin, noting its strong effectiveness in clearing active breakouts, reducing inflammation, and fading post-acne hyperpigmentation. The lightweight formula absorbs quickly and improves overall skin texture, though a small number of users experienced temporary dryness or a brief purging phase.

- Liked: Reduces acne breakouts (mostly mentioned)
- Liked: Fades post-acne marks (often mentioned)
- Liked: Absorbs very quickly (sometimes noted)
- Liked: Calms skin redness (sometimes noted)
- Disliked: Causes mild dryness (rarely noted)
- Disliked: Faulty pump dispenser (rarely noted)
- Disliked: Initial skin purging (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Jole Jole Azelaic Acid 10% Serum a great fit for combination skin?

This serum is a great fit for your combination skin because azelaic acid and niacinamide help control oily shine and reduce pore appearance. Soothing ingredients like bisabolol and allantoin also calm redness and inflammation, ensuring a comfortable experience without harshness.
Sources: [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/), [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/)

### Which ingredients make this serum a good fit for combination skin?

Azelaic acid and niacinamide make this serum a great fit for combination skin because they help control oily shine and reduce the look of pores. Soothing ingredients like bisabolol and allantoin further calm the skin for a comfortable experience.
Sources: [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/), [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/)

### What does Azelaic Acid do for combination skin?

Azelaic acid helps combination skin by calming redness, clearing breakouts, and fading dark spots while keeping the skin smooth. It is unlikely to irritate dry areas while working on oily spots. Combination skin of this type needs a balanced routine with gentle exfoliants and soothing hydrators.
Sources: [Postepy Dermatologii I Alergologii, 2023](https://pubmed.ncbi.nlm.nih.gov/38282869/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26355614/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine after cleansing and toning, and before moisturizing. Treatments are placed in the evening for simplicity and extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying your retinol first and following with this treatment, or by using them on alternate nights to keep your skin calm. This helps prevent strong tingling or redness since both ingredients are active.

### How often should I use this serum?

This treatment is used in your evening routine once a week to start, and people who tolerate it well and see good results can carefully use it more often. Azelaic acid and niacinamide help control oily shine and acne while keeping your skin comfortable.
Sources: [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/), [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores, but initial skin purging is a low possibility for combination skin. Azelaic acid and niacinamide help control oily shine and reduce pore appearance, while gentle soothing ingredients keep the skin comfortable.
Sources: [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — $28.88 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — $200.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — $18.99 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Ethoxydiglycol, Azelaic Acid, Niacinamide, Glyceryl Glucoside, Squalane, Bisabolol, Allantoin, Ammonium Acryloyldimethyltaurate Vp Copolymer, Valine, Proline, Lysine, Serine, Sorbitan Caprylate, 1,2 Propanediol, Benzoic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/jole/azelaic-acid-10-serum/for/combination-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/jole/azelaic-acid-10-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/jole/azelaic-acid-10-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/jole/azelaic-acid-10-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/jole/azelaic-acid-10-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/jole/azelaic-acid-10-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/jole/azelaic-acid-10-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/jole/azelaic-acid-10-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/jole/azelaic-acid-10-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/jole/azelaic-acid-10-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/jole/azelaic-acid-10-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/jole/azelaic-acid-10-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/jole/azelaic-acid-10-serum/for/combination-skin