# Isntree C-Niacin Toning Ampoule for oily skin

**Lovi Fit: High fit for oily skin.**
Oily Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Isntree](https://lovi.care/skincare/brands/isntree)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your oily skin is provided by niacinamide and 3-O-ethyl ascorbic acid, which work to control sebum and offer antioxidant activity, respectively. These ingredients also contribute to brightening and evening your skin tone, addressing your main goal of reducing oily shine.
- The formula is safe for your skin, with no risks of irritation due to the absence of harsh ingredients, and offers moderate benefits for controlling oiliness.
- The overall safety profile is excellent, with no risks of irritation for your oily skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/oily-skin): High (this page)
- [Dry skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin): Superior

## Key ingredients

Niacinamide, 3-O-Ethyl Ascorbic Acid Ascorbic Acid, Hippophae Rhamnoides Fruit Extract, Sodium Hyaluronate, Aloe Barbadensis Leaf Extract

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- A multi-component dissolving microneedle patch loaded with glabridin, 3-O-ethyl-L-ascorbic acid, and tranexamic acid effectively reduced chloasma and age spots while demonstrating safety in clinical evaluation, alongside significant antioxidant, anti-tyrosinase, and melanin-reduction effects in vitro and in vivo. ([Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/))
- Topical application of a sea buckthorn fruit extract formulation significantly reduced skin sebum secretion in 10 healthy human volunteers compared to the control base over an 8-week period. ([Journal of Pharmacy & Bioallied Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/21814424/))
- Topical emulsions containing Hippophae rhamnoides and Cassia fistula plant extracts significantly reduced skin sebum contents compared to placebo in patients with grade I and grade II acne vulgaris. ([Postepy Dermatologii I Alergologii, 2014](https://pubmed.ncbi.nlm.nih.gov/25254008/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of a 5% Hippophae rhamnoides oil-in-water emulsion significantly improved skin hydration (p=0.0003) and transepidermal water loss (p=0.0087) compared to a placebo base formulation in 13 healthy male subjects over 84 days. ([Pakistan Journal of Pharmaceutical Sciences, 2014](https://pubmed.ncbi.nlm.nih.gov/25362595/))
- Sea buckthorn seed oil prevents UV-induced disturbances in redox balance and lipid metabolism in human keratinocytes and fibroblasts by reducing reactive oxygen species and lipid peroxidation products while enhancing antioxidant levels. ([Antioxidants, 2018](https://pubmed.ncbi.nlm.nih.gov/30142919/))
- Sea buckthorn proanthocyanidins protected human skin fibroblasts against hydrogen peroxide-induced oxidative stress by enhancing antioxidant enzyme activities, promoting collagen synthesis via the TGF-beta1/Smads pathway, and inhibiting collagen degradation through the MMPs/TIMPs system. ([Antioxidants, 2022](https://pubmed.ncbi.nlm.nih.gov/36290623/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))

## What reviewers say

This ampoule is frequently praised for its lightweight, fast-absorbing texture and its ability to gently brighten the skin, providing a natural glow. It is well-tolerated by sensitive and acne-prone skin types. Some users report that results are subtle and require consistent long-term use, with a few experiencing minor breakouts or noting the watery consistency can be difficult to handle.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Brightens and glows (often mentioned)
- Liked: Gentle on sensitive skin (often mentioned)
- Liked: Hydrating (sometimes noted)
- Disliked: Slow or minimal results (sometimes noted)
- Disliked: Minor breakouts (rarely noted)
- Disliked: Runny consistency (rarely noted)
- Disliked: Slight tackiness (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Isntree C-Niacin Toning Ampoule a great fit for oily skin?

This product is a great fit because niacinamide and sea buckthorn fruit extract help control sebum and reduce oily shine. It also features vitamin C and niacinamide to brighten and even out your skin tone while remaining gentle and safe for oily skin.
Sources: [Journal of Pharmacy & Bioallied Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/21814424/), [Postepy Dermatologii I Alergologii, 2014](https://pubmed.ncbi.nlm.nih.gov/25254008/)

### Which ingredients make this serum a good fit for oily skin?

Niacinamide and 3-O-ethyl ascorbic acid make this serum a great fit by helping to control sebum and provide antioxidant benefits. Sea buckthorn fruit extract further helps reduce oily shine and keep skin balanced.
Sources: [Journal of Pharmacy & Bioallied Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/21814424/), [Postepy Dermatologii I Alergologii, 2014](https://pubmed.ncbi.nlm.nih.gov/25254008/)

### What does Niacinamide do for oily skin?

Niacinamide helps balance oily skin by significantly reducing excess oil production and shine. It is well tolerated and may improve skin texture without clogging pores.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does 3-O-Ethyl Ascorbic Acid do for oily skin?

3-O-Ethyl Ascorbic Acid helps brighten an uneven skin tone and reduces signs of aging. It works well on oily skin by delivering vitamin C to improve clarity without clogging pores.
Sources: [Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/38794349/), [Pharmaceutics, 2023](https://pubmed.ncbi.nlm.nih.gov/36986679/)

### Where does it go in a skincare routine for oily skin?

This treatment goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. Niacinamide and 3-o-ethyl ascorbic acid help control sebum and brighten skin without causing irritation.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following with your retinol once it absorbs, which helps manage oiliness while keeping your skin calm. The formula is safe for your skin, with no risk of irritation from harsh ingredients.
Sources: [Journal of Pharmacy & Bioallied Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/21814424/), [Postepy Dermatologii I Alergologii, 2014](https://pubmed.ncbi.nlm.nih.gov/25254008/)

### How often should I use it?

This treatment fits into your evening routine and is typically used once a day. The formula helps control oily shine without harsh ingredients, making it very safe for daily use.
Sources: [Journal of Pharmacy & Bioallied Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/21814424/), [Postepy Dermatologii I Alergologii, 2014](https://pubmed.ncbi.nlm.nih.gov/25254008/)

### Can it clog pores, cause breakouts or purging for oily skin?

This product is unlikely to clog pores or cause breakouts for oily skin, as it has an excellent safety profile without harsh ingredients. Minor breakouts are only a low complaint among reviewers.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/oily-skin) — Superior fit — $28.88 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/oily-skin) — High fit — $39.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — $15.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $17.90 (https://www.amazon.com/dp/B07VYVRXJ6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Hippophae Rhamnoides Fruit Extract, Butylene Glycol, Pentylene Glycol, Glycerin, Betaine, Water, Niacinamide, Propanediol, Aloe Barbadensis Leaf Extract, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Pumpkin Fruit Extract, Physalis Alkekengi Fruit Extract, Sodium Hyaluronate, Dipotassium Glycyrrhizate, Ocimum Sanctum Leaf Extract, Beta-Glucan, Curcuma Longa Root Extract, Corallina Officinalis Extract, Brassica Oleracea Italica Extract, Coccinia Indica Fruit Extract, Moringa Oleifera Seed Oil, Boswellia Serrata Extract Resin, Bioflavonoids, Panthenol, Allantoin, Sodium Polyacrylate, Tocopherol, Polysorbate 80, 1,2-Hexanediol, Ethyl Hexanediol, Ammonium Acryloyldimethyltaurate Vp Copolymer, 3-O-Ethyl Ascorbic Acid, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Usnea Barbata Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/oily-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/isntree/c-niacin-toning-ampoule/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/isntree/c-niacin-toning-ampoule/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/isntree/c-niacin-toning-ampoule/for/oily-skin
- France: https://lovi.care/skincare/fr/p/isntree/c-niacin-toning-ampoule/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/isntree/c-niacin-toning-ampoule/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/isntree/c-niacin-toning-ampoule/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/isntree/c-niacin-toning-ampoule/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/isntree/c-niacin-toning-ampoule/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/isntree/c-niacin-toning-ampoule/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/isntree/c-niacin-toning-ampoule/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/isntree/c-niacin-toning-ampoule/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/isntree/c-niacin-toning-ampoule/for/oily-skin