# Isntree C-Niacin Toning Ampoule for oily acne-prone skin

**Lovi Fit: Superior fit for oily acne-prone skin.**
Oily Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Isntree](https://lovi.care/skincare/brands/isntree)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for oily acne-prone skin.

## Why this fit

- Excellent suitability for your oily skin as 3-O-Ethyl Ascorbic Acid and Niacinamide work synergistically to regulate oil production and brighten your complexion. Hippophae Rhamnoides Fruit Extract further enhances these benefits by providing antioxidant protection and supporting skin clarity.
- The inclusion of Aloe Barbadensis Leaf Extract and Allantoin offers significant soothing properties, ensuring comfort and reducing any potential for irritation on your skin.
- This formula is exceptionally safe for your skin, with no harsh ingredients and a focus on calming and beneficial components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin): Superior (this page)

## Key ingredients

Niacinamide, 3-O-Ethyl Ascorbic Acid Ascorbic Acid, Hippophae Rhamnoides Fruit Extract, Sodium Hyaluronate, Aloe Barbadensis Leaf Extract

## What the research says

- Topical application of a sea buckthorn fruit extract formulation significantly reduced skin sebum secretion in 10 healthy human volunteers compared to the control base over an 8-week period. ([Journal of Pharmacy & Bioallied Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/21814424/))
- Topical emulsions containing Hippophae rhamnoides and Cassia fistula plant extracts significantly reduced skin sebum contents compared to placebo in patients with grade I and grade II acne vulgaris. ([Postepy Dermatologii I Alergologii, 2014](https://pubmed.ncbi.nlm.nih.gov/25254008/))
- A multi-component dissolving microneedle patch loaded with glabridin, 3-O-ethyl-L-ascorbic acid, and tranexamic acid effectively reduced chloasma and age spots while demonstrating safety in clinical evaluation, alongside significant antioxidant, anti-tyrosinase, and melanin-reduction effects in vitro and in vivo. ([Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of a 5% Hippophae rhamnoides oil-in-water emulsion significantly improved skin hydration (p=0.0003) and transepidermal water loss (p=0.0087) compared to a placebo base formulation in 13 healthy male subjects over 84 days. ([Pakistan Journal of Pharmaceutical Sciences, 2014](https://pubmed.ncbi.nlm.nih.gov/25362595/))
- Sea buckthorn seed oil prevents UV-induced disturbances in redox balance and lipid metabolism in human keratinocytes and fibroblasts by reducing reactive oxygen species and lipid peroxidation products while enhancing antioxidant levels. ([Antioxidants, 2018](https://pubmed.ncbi.nlm.nih.gov/30142919/))
- Sea buckthorn proanthocyanidins protected human skin fibroblasts against hydrogen peroxide-induced oxidative stress by enhancing antioxidant enzyme activities, promoting collagen synthesis via the TGF-beta1/Smads pathway, and inhibiting collagen degradation through the MMPs/TIMPs system. ([Antioxidants, 2022](https://pubmed.ncbi.nlm.nih.gov/36290623/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))
- Formulations containing 0.10%, 0.25%, and 0.50% freeze-dried Aloe vera extract increased stratum corneum water content compared with the vehicle in 20 female subjects, while transepidermal water loss was not modified. ([Skin Research and Technology, 2006](https://pubmed.ncbi.nlm.nih.gov/17026654/))

## What reviewers say

This ampoule is frequently praised for its lightweight, fast-absorbing texture and its ability to gently brighten the skin, providing a natural glow. It is well-tolerated by sensitive and acne-prone skin types. Some users report that results are subtle and require consistent long-term use, with a few experiencing minor breakouts or noting the watery consistency can be difficult to handle.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Brightens and glows (often mentioned)
- Liked: Gentle on sensitive skin (often mentioned)
- Liked: Hydrating (sometimes noted)
- Disliked: Slow or minimal results (sometimes noted)
- Disliked: Minor breakouts (rarely noted)
- Disliked: Runny consistency (rarely noted)
- Disliked: Slight tackiness (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Isntree C-Niacin Toning Ampoule one of the best fits for oily acne-prone skin?

This product is one of the best fits because 3-O-Ethyl Ascorbic Acid and Niacinamide work together to balance oil and brighten your complexion while sea buckthorn fruit extract helps keep your skin clear and calm. Soothing ingredients like aloe leaf extract and allantoin help ensure comfort and reduce the likelihood of irritation.
Sources: [Journal of Pharmacy & Bioallied Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/21814424/), [Postepy Dermatologii I Alergologii, 2014](https://pubmed.ncbi.nlm.nih.gov/25254008/)

### Which ingredients make this ampoule a good fit for oily acne-prone skin?

This ampoule is a great fit for your oily acne-prone skin because 3-O-Ethyl Ascorbic Acid and niacinamide work together to control oil and brighten your complexion. Sea buckthorn extract and aloe vera further help by supporting clear skin and keeping your face calm and comfortable.
Sources: [Journal of Pharmacy & Bioallied Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/21814424/), [Postepy Dermatologii I Alergologii, 2014](https://pubmed.ncbi.nlm.nih.gov/25254008/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### What does 3-O-Ethyl Ascorbic Acid do for oily acne-prone skin?

3-O-Ethyl Ascorbic Acid helps brighten an even skin tone and reduces signs of aging on oily acne-prone skin. It delivers vitamin C effectively to the skin to support a clearer, more balanced complexion.
Sources: [Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/38794349/)

### Where does this ampoule go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine after your cleansing toner and before your moisturizer. Niacinamide and vitamin C help regulate oil production and brighten your complexion while soothing ingredients keep your skin calm and comfortable.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this ampoule with retinol, and in what order?

Yes, you can use this ampoule with retinol by applying the ampoule after cleansing and toning, and following with your retinol and moisturizer in your evening routine. This safe formula helps soothe your skin and keeps oil in check while you use a retinoid.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [Journal of Pharmacy & Bioallied Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/21814424/)

### How often should I use this ampoule?

This treatment fits into your evening routine as a step after your cleansing toner. It helps regulate oil and brighten your complexion while remaining very safe and calming for your skin.
Sources: [Journal of Pharmacy & Bioallied Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/21814424/), [Postepy Dermatologii I Alergologii, 2014](https://pubmed.ncbi.nlm.nih.gov/25254008/)

### Can this ampoule clog pores, cause breakouts or purging for oily acne-prone skin?

This ampoule is unlikely to clog pores or cause breakouts on oily acne-prone skin, as it features a very safe formula with calming ingredients like niacinamide and aloe vera. Reviewers only occasionally mention minor breakouts.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/)

### Is this ampoule fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — $25.08 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — $25.08 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $17.90 (https://www.amazon.com/dp/B07VYVRXJ6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Hippophae Rhamnoides Fruit Extract, Butylene Glycol, Pentylene Glycol, Glycerin, Betaine, Water, Niacinamide, Propanediol, Aloe Barbadensis Leaf Extract, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Pumpkin Fruit Extract, Physalis Alkekengi Fruit Extract, Sodium Hyaluronate, Dipotassium Glycyrrhizate, Ocimum Sanctum Leaf Extract, Beta-Glucan, Curcuma Longa Root Extract, Corallina Officinalis Extract, Brassica Oleracea Italica Extract, Coccinia Indica Fruit Extract, Moringa Oleifera Seed Oil, Boswellia Serrata Extract Resin, Bioflavonoids, Panthenol, Allantoin, Sodium Polyacrylate, Tocopherol, Polysorbate 80, 1,2-Hexanediol, Ethyl Hexanediol, Ammonium Acryloyldimethyltaurate Vp Copolymer, 3-O-Ethyl Ascorbic Acid, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Usnea Barbata Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin