# IOPE PDRN Caffeine Shot Serum for oily skin

**Lovi Fit: High fit for oily skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [IOPE](https://lovi.care/skincare/brands/iope)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your oily skin due to the presence of niacinamide and caffeine which offer seboregulation and antioxidant activity.
- The serum provides excellent skin firming and plumping benefits from Acetyl Tetrapeptide-11, while Glycerin and Beta-Glucan offer supportive hydration and soothing effects for general skincare.
- The safety profile is excellent, with no risks of irritation for your oily skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/oily-skin): High (this page)
- [Dry skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Bio-Pdrn, Caffeine, Niacinamide, Adenosine, Lactobacillus Lysate Ferment

## What the research says

- Topical caffeine acts as an active cosmetic compound by preventing excessive fat accumulation through phosphodiesterase inhibition, protecting cells against UV radiation with antioxidant properties, increasing skin microcirculation, and stimulating hair growth via 5-alpha-reductase inhibition. ([Skin Pharmacology and Physiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23075568/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Topical sunscreen formulations containing caffeine combined with UV filters increased in vivo anti-UVB protection by approximately 25% and showed higher SPF values compared to caffeine-free sunscreen, while being well tolerated by the skin of healthy subjects. ([Frontiers in Physiology, 2019](https://pubmed.ncbi.nlm.nih.gov/31130869/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- A topical cosmetic slimming product containing tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol significantly reduced body circumferences and improved skin aspect compared with placebo in 78 women over 12 weeks. ([International Journal of Cosmetic Science, 2011](https://pubmed.ncbi.nlm.nih.gov/21564138/))
- Caffeine gel combined with choline geranate showed high skin permeation capacity and superior clinical results in cellulite treatment compared to caffeine gel without ionic liquid. ([AAPS PharmSciTech, 2021](https://pubmed.ncbi.nlm.nih.gov/33796955/))
- Caffeine stimulates metabolic activity in hair follicles and acts as an antioxidant through adenosine pathway interactions, showing potential as an effective and safe management option for hair loss despite current study limitations. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/39795223/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Probiotic-derived lotion successfully reduced inflammatory acne lesion counts and erythema index comparably to 2.5% benzoyl peroxide in patients with mild-to-moderate acne vulgaris, while causing fewer side effects. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35384257/))
- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))
- Lactobacillus plantarum extracellular vesicles modulated extracellular matrix related gene expression in vitro and suppressed wrinkle formation and pigmentation in clinical trials. ([Current Issues in Molecular Biology, 2022](https://pubmed.ncbi.nlm.nih.gov/35723322/))

## What reviewers say

Based on a very large amount of data, users consistently praise this serum for its lightweight, fast-absorbing texture and its ability to visibly reduce facial puffiness and refine skin texture. While highly effective for "de-puffing" and strengthening the moisture barrier, some users with very dry skin find it requires an additional moisturizer, and the high price point is a frequent point of contention.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Reduces puffiness (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Gentle on skin (sometimes noted)
- Liked: Improves skin barrier (sometimes noted)
- Disliked: Dry skin needs more (sometimes noted)
- Disliked: Minor breakouts (rarely noted)
- Disliked: Subtle anti-aging (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes IOPE PDRN Caffeine Shot Serum a great fit for oily skin?

IOPE PDRN Caffeine Shot Serum is a great fit for oily skin because it contains niacinamide and caffeine, which help balance oil and protect against damage with antioxidant activity. Glycerin and beta-glucan provide supportive hydration and soothing effects, while the formula has an excellent safety profile without harsh ingredients that might cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Which ingredients make this serum a good fit for oily skin?

This serum is a great fit for oily skin because it contains niacinamide and caffeine, which help control oil and provide antioxidant protection. It is also very safe and unlikely to cause irritation since it lacks harsh ingredients.
Sources: [Skin Pharmacology and Physiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23075568/)

### What does Bio-PDRN do for oily skin?

Bio-PDRN helps calm oily skin by reducing inflammation and supporting tissue repair. It works to manage skin irritation and helps keep the skin smooth while promoting a balanced, healthy look.
Sources: [Regenerative Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32757710/), [Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/)

### What does Caffeine do for oily skin?

Topical caffeine helps keep oily skin looking fresh by preventing excessive fat accumulation and boosting microcirculation. It is generally well tolerated and provides antioxidant protection against sun damage.
Sources: [Frontiers in Physiology, 2019](https://pubmed.ncbi.nlm.nih.gov/31130869/), [Skin Pharmacology and Physiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23075568/)

### Where does this serum go in a skincare routine for oily skin?

This serum goes in your evening routine, applied after cleansing and toning and before your moisturizer. Putting it in the evening keeps things simple and adds safety around sun exposure, while niacinamide and caffeine help manage oil.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol, but it is best to apply retinol first, let it sink in, and then follow with this serum to keep your skin calm and hydrated. This formula is unlikely to cause irritation on oily skin, and using it alongside retinol helps maintain a smooth and firm feel.

### How often should I use this serum?

This serum is a great fit for your oily skin and is used in the evening as part of your routine. It is unlikely to cause irritation and helps balance oil while keeping your skin calm and hydrated.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Can this serum clog pores, cause breakouts or purging for oily skin?

This serum is a great fit for oily skin and has an excellent safety profile, meaning it is unlikely to cause irritation or breakouts. Reviewers report only low chances of minor breakouts, and the formula avoids harsh ingredients that typically clog pores.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/oily-skin) — Superior fit — $28.88 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/oily-skin) — High fit — $39.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — $15.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $43.00 (https://www.amazon.com/dp/B0BJQ86VNH?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Lactobacillus Lysate Ferment, Water, Propanediol, Glycerin, Niacinamide, Butylene Glycol, Caffeine, Dipropylene Glycol, 2-Hexanediol, Diethoxyethyl Succinate, Glyceryl Polymethacrylate, Polyacrylate Crosspolymer-6, Mannitol, Ethylhexylglycerin, Adenosine, Sodium Citrate, Dextrin, Theobroma Cacao Extract, Citric Acid, Disodium Edta, T-Butyl Alcohol, Arginine, Cyclodextrin, Hydroxypropyl Cyclodextrin, Maltodextrin, Xanthan Gum, Beta-Glucan, Acetyl Tetrapeptide-11, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/oily-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/iope/pdrn-caffeine-shot-serum/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/iope/pdrn-caffeine-shot-serum/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/iope/pdrn-caffeine-shot-serum/for/oily-skin
- France: https://lovi.care/skincare/fr/p/iope/pdrn-caffeine-shot-serum/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/iope/pdrn-caffeine-shot-serum/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/iope/pdrn-caffeine-shot-serum/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/iope/pdrn-caffeine-shot-serum/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/iope/pdrn-caffeine-shot-serum/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/iope/pdrn-caffeine-shot-serum/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/iope/pdrn-caffeine-shot-serum/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/iope/pdrn-caffeine-shot-serum/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/iope/pdrn-caffeine-shot-serum/for/oily-skin