# IOPE PDRN Caffeine Shot Serum for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [IOPE](https://lovi.care/skincare/brands/iope)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate skin treatment for your oily skin, as niacinamide and adenosine help with evening skin tone and minimizing fine lines, while caffeine supports seboregulation and antioxidant activity.
- The formulation provides general skincare benefits like hydration and soothing, which are supportive for your acne, blemishes, and breakouts.
- The product is safe for your oily skin with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Bio-Pdrn, Caffeine, Niacinamide, Adenosine, Lactobacillus Lysate Ferment

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- A topical cosmetic slimming product containing tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol significantly reduced body circumferences and improved skin aspect compared with placebo in 78 women over 12 weeks. ([International Journal of Cosmetic Science, 2011](https://pubmed.ncbi.nlm.nih.gov/21564138/))
- Topical sunscreen formulations containing caffeine combined with UV filters increased in vivo anti-UVB protection by approximately 25% and showed higher SPF values compared to caffeine-free sunscreen, while being well tolerated by the skin of healthy subjects. ([Frontiers in Physiology, 2019](https://pubmed.ncbi.nlm.nih.gov/31130869/))
- Caffeine gel combined with choline geranate showed high skin permeation capacity and superior clinical results in cellulite treatment compared to caffeine gel without ionic liquid. ([AAPS PharmSciTech, 2021](https://pubmed.ncbi.nlm.nih.gov/33796955/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Adenosine treatment of dermal papilla cells upregulates fibroblast growth factor-7 expression via the A2b adenosine receptor and intracellular cAMP signaling, and fibroblast growth factor-7 significantly stimulates hair fiber elongation in human scalp hair follicle organ cultures. ([The Journal of Investigative Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17301835/))
- Probiotic-derived lotion successfully reduced inflammatory acne lesion counts and erythema index comparably to 2.5% benzoyl peroxide in patients with mild-to-moderate acne vulgaris, while causing fewer side effects. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35384257/))
- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))
- Lactobacillus plantarum extracellular vesicles modulated extracellular matrix related gene expression in vitro and suppressed wrinkle formation and pigmentation in clinical trials. ([Current Issues in Molecular Biology, 2022](https://pubmed.ncbi.nlm.nih.gov/35723322/))

## What reviewers say

Based on a very large amount of data, users consistently praise this serum for its lightweight, fast-absorbing texture and its ability to visibly reduce facial puffiness and refine skin texture. While highly effective for "de-puffing" and strengthening the moisture barrier, some users with very dry skin find it requires an additional moisturizer, and the high price point is a frequent point of contention.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Reduces puffiness (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Gentle on skin (sometimes noted)
- Liked: Improves skin barrier (sometimes noted)
- Disliked: Dry skin needs more (sometimes noted)
- Disliked: Minor breakouts (rarely noted)
- Disliked: Subtle anti-aging (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does IOPE Caffeine Shot Serum work for oily acne-prone skin?

IOPE PDRN Caffeine Shot Serum works moderately well for your oily acne-prone skin, providing gentle hydration and evening out your skin tone while supporting oil control. A product of this type needs specialized ingredients like niacinamide and soothing extracts that target excess oil and blemishes without feeling heavy, while keeping your skin calm and comfortable.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Niacinamide and adenosine help even out skin tone and smooth fine lines, while caffeine helps control excess oil. Treatments that fit this skin best also need ingredients like propolis or Vitamin C to provide even better oil control and acne care.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Bio-PDRN do for oily acne-prone skin?

Bio-PDRN helps calm oily acne-prone skin and supports skin recovery. A product of this type needs soothing ingredients and lightweight hydrators to keep pores clear and balance oil without feeling heavy.
Sources: [Pharmaceutics, 2025](https://pubmed.ncbi.nlm.nih.gov/40871045/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35427427/)

### What does Caffeine do for oily acne-prone skin?

Topical caffeine helps calm oily, acne-prone skin by protecting cells against UV damage and preventing excessive fat accumulation. It is also well tolerated and may boost your sunscreen protection when used together with UV filters.
Sources: [Skin Pharmacology and Physiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23075568/), [Frontiers in Physiology, 2019](https://pubmed.ncbi.nlm.nih.gov/31130869/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

Apply this serum in your evening routine after cleansing and before moisturizing. Oily acne-prone skin needs a treatment that combines soothing ferment extracts, balancing caffeine, and blemish-clearing ingredients like niacinamide to keep skin calm and clear.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/), [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36798538/)

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol, applying the treatment after your cleanser and before your moisturizer. It is generally safe for your skin, but oily acne-prone skin typically benefits more from targeted ingredients like salicylic acid or benzoyl peroxide to actively clear breakouts.

### How often should I use this serum?

You can use this serum in your evening routine, applying it after cleansing and toning. This product of this type needs lightweight hydration, soothing ingredients, and gentle blemish-fighting actives to effectively care for oily, acne-prone skin.

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to clog pores or cause purging on oily acne-prone skin since it lacks harsh ingredients, though reviewers occasionally report minor breakouts. A product for this skin works best when it includes oil-balancing ingredients and lightweight hydrators to keep breakouts calm without feeling heavy.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — $25.08 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — $25.08 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $43.00 (https://www.amazon.com/dp/B0BJQ86VNH?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Lactobacillus Lysate Ferment, Water, Propanediol, Glycerin, Niacinamide, Butylene Glycol, Caffeine, Dipropylene Glycol, 2-Hexanediol, Diethoxyethyl Succinate, Glyceryl Polymethacrylate, Polyacrylate Crosspolymer-6, Mannitol, Ethylhexylglycerin, Adenosine, Sodium Citrate, Dextrin, Theobroma Cacao Extract, Citric Acid, Disodium Edta, T-Butyl Alcohol, Arginine, Cyclodextrin, Hydroxypropyl Cyclodextrin, Maltodextrin, Xanthan Gum, Beta-Glucan, Acetyl Tetrapeptide-11, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin