# IOPE PDRN Caffeine Shot Serum for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [IOPE](https://lovi.care/skincare/brands/iope)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your dry skin, as Glycerin and Beta-Glucan provide humectant action and barrier repair, while caffeine and niacinamide energize and improve skin tone.
- The formula is generally safe for your dry skin, lacking harsh ingredients that could cause irritation.
- While it addresses general skincare needs, it lacks specialized ingredients to directly target dryness and flakiness.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Bio-Pdrn, Caffeine, Niacinamide, Adenosine, Lactobacillus Lysate Ferment

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- A topical cosmetic slimming product containing tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol significantly reduced body circumferences and improved skin aspect compared with placebo in 78 women over 12 weeks. ([International Journal of Cosmetic Science, 2011](https://pubmed.ncbi.nlm.nih.gov/21564138/))
- Topical sunscreen formulations containing caffeine combined with UV filters increased in vivo anti-UVB protection by approximately 25% and showed higher SPF values compared to caffeine-free sunscreen, while being well tolerated by the skin of healthy subjects. ([Frontiers in Physiology, 2019](https://pubmed.ncbi.nlm.nih.gov/31130869/))
- Caffeine gel combined with choline geranate showed high skin permeation capacity and superior clinical results in cellulite treatment compared to caffeine gel without ionic liquid. ([AAPS PharmSciTech, 2021](https://pubmed.ncbi.nlm.nih.gov/33796955/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Probiotic-derived lotion successfully reduced inflammatory acne lesion counts and erythema index comparably to 2.5% benzoyl peroxide in patients with mild-to-moderate acne vulgaris, while causing fewer side effects. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35384257/))
- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))
- Lactobacillus plantarum extracellular vesicles modulated extracellular matrix related gene expression in vitro and suppressed wrinkle formation and pigmentation in clinical trials. ([Current Issues in Molecular Biology, 2022](https://pubmed.ncbi.nlm.nih.gov/35723322/))

## Why other serums fit dry skin better

- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))

## What reviewers say

Based on a very large amount of data, users consistently praise this serum for its lightweight, fast-absorbing texture and its ability to visibly reduce facial puffiness and refine skin texture. While highly effective for "de-puffing" and strengthening the moisture barrier, some users with very dry skin find it requires an additional moisturizer, and the high price point is a frequent point of contention.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Reduces puffiness (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Gentle on skin (sometimes noted)
- Liked: Improves skin barrier (sometimes noted)
- Disliked: Dry skin needs more (sometimes noted)
- Disliked: Minor breakouts (rarely noted)
- Disliked: Subtle anti-aging (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does IOPE PDRN Caffeine Shot work for dry skin?

IOPE PDRN Caffeine Shot Serum is an average fit for dry skin, offering moderate moisture and tone improvement through glycerin and niacinamide. However, because it lacks specialized ingredients to directly target dryness and flakiness, dry skin needs products rich in deep hydrators, barrier-supporting ceramides, and soothing plant extracts.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry skin?

Glycerin and beta-glucan help make this serum a fit for dry skin by drawing in moisture and supporting the skin barrier, while caffeine and niacinamide improve skin tone. However, because it lacks specialized ingredients for dryness and flakiness, a treatment of this type needs rich hydrating ingredients like ceramides, propolis, or bifida ferment, along with soothing agents to fully care for dry skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Bio-PDRN do for dry skin?

Bio-PDRN helps nourish dry skin by supporting skin barrier repair and enhancing hydration. It is unlikely to cause irritation and may improve overall skin texture and softness.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37959659/), [Journal of Drugs in Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42696342/)

### What does Caffeine do for dry skin?

Caffeine helps protect skin cells against UV damage with antioxidants and increases microcirculation. It is unlikely to directly fix dry skin on its own, so dry skin types need added hydrating and barrier-repairing ingredients to stay soft and smooth.
Sources: [Skin Pharmacology and Physiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23075568/)

### Where does this serum go in a skincare routine for dry skin?

This serum goes in your evening routine after cleansing and before moisturizing. To best care for dry skin, this type of product also needs rich hydrators and soothing barrier oils.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol product, or by alternating the nights you use each to keep your dry skin calm. The formula is generally safe and lacks harsh ingredients that could cause irritation, but to truly care for dry skin it needs rich moisturizing ingredients like ceramides and rich plant oils.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. It is generally safe for your skin, but a product for dry skin needs extra rich moisturizers and barrier-repairing oils to lock in hydration.

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to cause breakouts on dry skin, as its formula lacks harsh ingredients that typically trigger irritation. Reviewers rarely mention breakouts, and it is generally safe for your skin type.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — $16.75 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — $53.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — $19.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — $19.99 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — $16.99 at Amazon
- Moisturizer: [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/dry-skin) — Superior fit — $22.00 at Amazon

## Where to buy

- Amazon.com: $43.00 (https://www.amazon.com/dp/B0BJQ86VNH?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Lactobacillus Lysate Ferment, Water, Propanediol, Glycerin, Niacinamide, Butylene Glycol, Caffeine, Dipropylene Glycol, 2-Hexanediol, Diethoxyethyl Succinate, Glyceryl Polymethacrylate, Polyacrylate Crosspolymer-6, Mannitol, Ethylhexylglycerin, Adenosine, Sodium Citrate, Dextrin, Theobroma Cacao Extract, Citric Acid, Disodium Edta, T-Butyl Alcohol, Arginine, Cyclodextrin, Hydroxypropyl Cyclodextrin, Maltodextrin, Xanthan Gum, Beta-Glucan, Acetyl Tetrapeptide-11, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/dry-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/iope/pdrn-caffeine-shot-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/iope/pdrn-caffeine-shot-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/iope/pdrn-caffeine-shot-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/iope/pdrn-caffeine-shot-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/iope/pdrn-caffeine-shot-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/iope/pdrn-caffeine-shot-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/iope/pdrn-caffeine-shot-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/iope/pdrn-caffeine-shot-serum/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/iope/pdrn-caffeine-shot-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/iope/pdrn-caffeine-shot-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/iope/pdrn-caffeine-shot-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/iope/pdrn-caffeine-shot-serum/for/dry-skin