# Image Skincare the MAX™ Stem Cell Serum for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/image-skincare/the-maxtm-stem-cell-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Image Skincare](https://lovi.care/skincare/brands/image-skincare)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- Offers excellent anti-aging benefits for your combination skin, with Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-38 working to minimize fine lines and wrinkles. Sodium Hyaluronate and Camellia Sinensis Leaf Extract provide hydration and antioxidant support, which are beneficial but not specifically targeted for your acne concerns.
- The serum is safe for your combination skin, as it lacks harsh ingredients that could cause irritation.
- It provides general skincare benefits like hydration and antioxidant support, which are helpful but do not directly address your primary concerns of acne, blemishes, and breakouts.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/image-skincare/the-maxtm-stem-cell-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/image-skincare/the-maxtm-stem-cell-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/image-skincare/the-maxtm-stem-cell-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/image-skincare/the-maxtm-stem-cell-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/image-skincare/the-maxtm-stem-cell-serum/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/p/image-skincare/the-maxtm-stem-cell-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/image-skincare/the-maxtm-stem-cell-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/image-skincare/the-maxtm-stem-cell-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/image-skincare/the-maxtm-stem-cell-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Pyrus Malus Extract Cell Fruit Culture, Sodium Hyaluronate, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Tetrahexyldecyl Ascorbate

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG. ([Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/))
- Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo. ([Experimental Dermatology, 2009](https://pubmed.ncbi.nlm.nih.gov/18631247/))
- A novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, creatine, and urea improved mitochondrial function in human senescent cultured fibroblasts and demonstrated anti-wrinkle, dermal density, and skin elasticity benefits in 32 women with sensitive skin applied twice daily for 28 days compared to baseline. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/26424007/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))

## Why other serums fit acne-prone skin better

- Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Users with mature, dry, or environmentally stressed skin frequently praise this serum for its hydrating, firming, and smoothing effects, which target fine lines and improve elasticity for a more youthful appearance. Some users note that consistent, long-term use is necessary to see the full benefits.

- Liked: Firms and tightens (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Liked: Absorbs quickly (sometimes noted)
- Liked: Hydrates and smooths (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Faulty pump (rarely noted)
- Disliked: Slow to show (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does the MAX Stem Cell Serum work for acne-prone skin?

This serum works reasonably well for your acne-prone skin, though other products fit it better because they target breakouts directly. While it provides helpful hydration and antioxidants, a product of this type needs acne-fighting ingredients like niacinamide, propolis, or zinc PCA to truly suit this skin type.

### Which ingredients make this serum a good fit for acne-prone skin?

This serum works for acne-prone skin because it provides general hydration and antioxidants, though other products fit this skin type better. To work best for acne-prone skin, a treatment of this type needs ingredients like niacinamide, propolis, and zinc PCA to target breakouts and control oiliness while keeping skin balanced.

### What does Apple Fruit Cell Culture Extract do for acne-prone skin?

Apple Fruit Cell Culture Extract is rich in antioxidants that help protect acne-prone skin from daily stress and damage. It is unlikely to clog pores and may support a clear, calm complexion when used in your routine.
Sources: [Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34885949/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in the evening routine after cleansing and before moisturizing, though products of this type for acne-prone skin need targeted ingredients like salicylic acid or niacinamide to help clear blemishes.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying it after your retinol treatment to help keep your skin hydrated. This product is safe and gentle for your skin, though an acne-prone skin type also needs targeted ingredients like salicylic acid or benzoyl peroxide to directly clear blemishes and breakouts.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

This serum works well in the evening routine. Acne-prone skin needs products with clarifying and soothing ingredients like salicylic acid, niacinamide, or tea tree oil to help clear breakouts.

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to clog pores or cause breakouts for your acne-prone skin, as it lacks harsh ingredients that could cause irritation. However, because it provides general hydration and antioxidant support rather than directly targeting blemishes, acne-prone skin needs products with ingredients that specifically clear pores, calm redness, and balance oil production.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — $28.88 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — $39.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — $15.60 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — $15.50 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Acetyl Hexapeptide-8, Sucrose Palmitate, Polysorbate 20, Tocopheryl Acetate, Pyrus Malus Extract Cell Fruit Culture, Plankton Extract, Sodium Hyaluronate, Hydrolyzed Rice Bran Protein, Imperata Cylindrica Root Extract, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-1, Algae Extract, Camellia Sinensis Leaf Extract, Spiraea Ulmaria Flower Extract, Centella Asiatica Extract, Echinacea Purpurea Extract, Phaseolus Radiatus L Callus Extract, Acetyl Octapeptide-3, Leontopodium Alpinum Meristem Cell Culture, Macrocystis Pyrifera Extract, Argania Spinosa Extract Cell Sprout Culture, Superoxide Dismutase, Palmitoyl Tripeptide-38, Hydroxypropyl Cyclodextrin, Hydrolyzed Wheat Protein, Arabidopsis Thaliana Extract, Lecithin, Butylene Glycol, Peg-8 Smdi Copolymer, Pullulan, Glycine Soja Protein Soybean Protein, Isomalt, Propylene Glycol, Glyceryl Polymethacrylate, Sodium Dextran Sulfate, Citric Acid, Pvp, Disodium Edta, Xanthan Gum, Sodium Benzoate, Potassium Sorbate, Hydroxyethylcellulose, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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