# HydroPeptide Power Serum for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/p/hydropeptide/power-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [HydroPeptide](https://lovi.care/skincare/brands/hydropeptide)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- This formulation is highly suitable for your oily skin, as Barosma Betulina Leaf Extract and Hexapeptide-11 work synergistically to regulate sebum production and condition the skin, addressing your concerns with acne, blemishes, and breakouts. Tetrahexyldecyl Ascorbate further aids in brightening your skin tone and smoothing texture, offering relevant benefits for your skin issues.
- The inclusion of Tocopherol and Glycerin ensures a gentle experience, minimizing irritation potential for your oily skin.
- This product is safe for your skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/hydropeptide/power-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/hydropeptide/power-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/p/hydropeptide/power-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/hydropeptide/power-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/hydropeptide/power-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/hydropeptide/power-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/hydropeptide/power-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/hydropeptide/power-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/hydropeptide/power-serum/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Palmitoyl Tripeptide-5, Hexapeptide-11, Acetyl Hexapeptide-30, Sodium Hyaluronate, Lemon Peel Extract

## What the research says

- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Hexapeptide-11 activated proteasome, autophagy, chaperones, and antioxidant response genes, protected fibroblasts against oxidative-stress-mediated premature cellular senescence, and improved skin elasticity in human subjects. ([Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/))
- Hexapeptide-11 reversibly downregulated ATM and p53 protein expression in intrinsically aged fibroblasts, extrinsically aged fibroblasts, and extrinsically aged dermal papillae cells at concentrations between 0.1% and 1.0% in vitro, thereby influencing the onset of cellular senescence. ([Journal of Cosmetic Science, 2013](https://pubmed.ncbi.nlm.nih.gov/23578831/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Users consistently praise this serum as a lightweight, non-greasy anti-aging powerhouse that visibly plumps and smooths the skin. While it is highly effective for hydrating dry skin and softening fine lines without irritating sensitive complexions, the high price point and distinct scent are occasional points of contention.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Visible anti-aging (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Gentle on skin (sometimes noted)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Packaging size (rarely noted)
- Disliked: Scent dislike (rarely noted)
- Disliked: Slow results (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Power Serum a great fit for oily acne-prone skin?

HydroPeptide Power Serum is a great fit because ingredients like Barosma Betulina Leaf Extract and Hexapeptide-11 help control excess oil and breakouts, while Tetrahexyldecyl Ascorbate brightens and smooths your skin. Tocopherol and Glycerin also help keep the formula gentle and unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Barosma Betulina Leaf Extract and Hexapeptide-11 help regulate oil and condition oily skin, while Tetrahexyldecyl Ascorbate brightens skin tone and smooths texture. Tocopherol and Glycerin also help keep the formula gentle and minimize irritation.

### What does Palmitoyl Tripeptide-5 do for oily acne-prone skin?

Palmitoyl tripeptide-5 helps smooth fine lines and firms the skin, though it is not a direct treatment for oily or acne-prone skin. This type of skin needs ingredients that help control excess oil, clear pores, and calm breakouts.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/)

### What does Hexapeptide-11 do for oily acne-prone skin?

Hexapeptide-11 helps protect skin cells from everyday damage and may improve firmness, but oily acne-prone skin also needs ingredients that control oil and soothe swelling to truly stay clear and smooth.
Sources: [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This serum goes in the evening routine after cleansing and before moisturizing, though some can also be used in the morning or twice a day. Applying treatments in the evening helps keep things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the retinol first at night, followed by this serum in your routine. This helps manage breakouts while keeping your skin calm, as the gentle ingredients minimize irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [American Family Physician, 2012](https://pubmed.ncbi.nlm.nih.gov/23062156/)

### How often should I use this serum?

You can use this serum in your evening routine, and some treatments like this one may also be used in the morning or twice a day. Its gentle ingredients are unlikely to cause irritation while helping to balance oil and brighten your skin.

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is a great fit for your oily acne-prone skin, as it uses ingredients that help control oil and condition the skin without clogging pores. It also includes gentle ingredients that minimize the likelihood of irritation or breakouts.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — $25.08 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — $25.08 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $160.00 (https://www.amazon.com/dp/B000URKRXS?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Glycerin, Lactococcus Lysate Ferment, Butylene Glycol, Propanediol, Diethylhexyl Carbonate, Isopentyldiol, Pentylene Glycol, Diheptyl Succinate, Caprylyl Glycol, Hydroxyacetophenone, Olea Europaea Fruit Olive Fruit, Sodium Stearoyl Glutamate, Cetearyl Alcohol, Glyceryl Stearate, Potassium Olivoyl Hydrolyzed Oat Protein, Lysolecithin, Sclerotium Gum, Hexapeptide-11, Tetrahexyldecyl Ascorbate, 1,2-Hexanediol, Capryloyl Glycerin Sebacic Acid Copolymer, Phenylpropanol, Sorbitan Laurate, Pullulan, Xanthan Gum, Caprylic Capric Triglyceride, Glyceryl Oleate, Glycine Soja Seed Extract Soybean Seed Extract, Anogeissus Leiocarpus Bark Extract, Lemon Peel Extract, Palmitoyl Hexapeptide-19, Sodium Phytate, Hydroxyethylcellulose, Sodium Hyaluronate, Acetyl Dipeptide-1 Cetyl Ester, Citrus Aurantium Dulcis Peel Extract, Grapefruit Fruit Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Bergamot Fruit Extract, Citrus Aurantifolia Peel Extract, Citrus Nobilis Fruit Extract Mandarin Orange Fruit Extract, Tangerine Peel Extract, Acetyl Hexapeptide-30, Barosma Betulina Leaf Extract, Vanilla Planifolia Fruit Extract, Vitis Vinifera Fruit Extract Grape Fruit Extract, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Tripeptide-5, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/hydropeptide/power-serum/for/oily-acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/hydropeptide/power-serum/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/hydropeptide/power-serum/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/hydropeptide/power-serum/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/hydropeptide/power-serum/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/hydropeptide/power-serum/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/hydropeptide/power-serum/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/hydropeptide/power-serum/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/hydropeptide/power-serum/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/hydropeptide/power-serum/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/hydropeptide/power-serum/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/hydropeptide/power-serum/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/hydropeptide/power-serum/for/oily-acne-prone-skin