# Good Molecules Super Peptide Serum for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/good-molecules/super-peptide-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Good Molecules](https://lovi.care/skincare/brands/good-molecules)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate hydration and plumping for your oily skin, with peptides like Acetyl Hexapeptide-8 and Copper Tripeptide-1 providing firming benefits, while capryloyl glycerin sebacic acid copolymer helps regulate oil production without clogging pores.
- Glycerin and sodium hyaluronate offer general skincare support by hydrating your skin, though they are not specifically targeted for your acne, blemishes, and breakouts.
- The product is safe for your oily skin, as it contains no harsh ingredients that would cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/good-molecules/super-peptide-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/good-molecules/super-peptide-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/good-molecules/super-peptide-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/good-molecules/super-peptide-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/good-molecules/super-peptide-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/good-molecules/super-peptide-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/good-molecules/super-peptide-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/good-molecules/super-peptide-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/good-molecules/super-peptide-serum/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Copper Tripeptide-1, Sodium Hyaluronate, Glycerin

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## Why other serums fit oily acne-prone skin better

- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Users consistently praise this serum for its ability to plump and hydrate the skin, with many noting a visible reduction in fine lines and improved skin texture over time. While most find it gentle and effective for the price, some users with sensitive skin noted the bergamot scent, and others felt it required long-term use to see significant anti-aging results.

- Liked: Great value (mostly mentioned)
- Liked: Plumps and hydrates (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Liked: Gentle formula (sometimes noted)
- Disliked: Scent complaints (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: No visible change (rarely noted)
- Disliked: Soapy texture (rarely noted)
- Disliked: Watery consistency (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Good Molecules Super Peptide Serum work for oily acne-prone skin?

Good Molecules Super Peptide Serum is an average fit for your oily acne-prone skin, offering moderate hydration and firming peptides alongside oil-regulating ingredients that do not clog pores. While it is safe and provides general skincare support, it lacks specific blemish-fighting ingredients found in higher-rated options. A product of this type needs acne-targeting ingredients like niacinamide, propolis, or Vitamin C to better handle blemishes and excess oil while keeping the skin clear.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

This serum fits your oily acne-prone skin with peptides like Acetyl Hexapeptide-8 and Copper Tripeptide-1 for firming, along with capryloyl glycerin sebacic acid copolymer to help manage oil without clogging pores. Glycerin and sodium hyaluronate also provide light hydration, though a treatment for this skin needs targeted ingredients like niacinamide, propolis, or Vitamin C to address breakouts and excess oil.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Argireline do for oily acne-prone skin?

Argireline is unlikely to treat acne or oiliness directly, as it focuses on reducing fine lines and making skin smooth. Oily acne-prone skin needs lightweight, non-greasy ingredients that clear pores and calm breakouts.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Acetyl Octapeptide-3 do for oily acne-prone skin?

Acetyl Octapeptide-3 helps smooth the look of expression lines and is generally gentle for oily, acne-prone skin. Because it targets fine lines rather than oil or breakouts, this type of product also needs oil-controlling ingredients like niacinamide to fully support clear skin.

### Where does it go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Oily acne-prone skin needs serums containing ingredients that target breakouts and control oil alongside firming peptides.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first and following it with your retinol. This product is unlikely to irritate your oily skin, but to properly care for acne-prone skin, it needs targeted ingredients that actively clear breakouts and blemishes.

### How often should I use it?

You can use this treatment in your evening routine for simplicity and safety around sun exposure, applying it after cleansing. This serum provides moderate hydration and firming peptides, but an oily acne-prone skin often needs targeted blemish-fighting ingredients and oil-balancing agents.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Can it clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to clog pores or cause breakouts on oily skin, as it contains no harsh ingredients and includes a copolymer that helps regulate oil production. However, because it only provides moderate hydration and lacks ingredients specifically targeted for blemishes and breakouts, oily acne-prone skin needs a treatment with added blemish-fighting ingredients to truly clear the skin.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — $25.08 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — $25.08 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $12.00 (https://www.amazon.com/dp/B091MTKS35?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Propanediol, Glycerin, 1,2-Hexanediol, Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Copper Tripeptide-1, Ethylhexylglycerin, Caprylyl Glycol, Glycine, Sodium Hyaluronate, Xanthan Gum, Ammonium Acryloyldimethyltaurate Vp Copolymer, Diheptyl Succinate, Capryloyl Glycerin Sebacic Acid Copolymer, Chlorphenesin, Disodium Edta, Butylene Glycol, Glycereth-25 Pca Isostearate, Bht, Phenoxyethanol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Sorbitan Isostearate, Polyacrylate-13, Polyisobutene, Polysorbate 20, Tromethamine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/good-molecules/super-peptide-serum/for/oily-acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/good-molecules/super-peptide-serum/for/oily-acne-prone-skin
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