# Goldfaden MD Radical Difference for dry sensitive skin

**Lovi Fit: High fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/goldfaden-md/radical-difference/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Goldfaden MD](https://lovi.care/skincare/brands/goldfaden-md)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry sensitive skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your dry skin due to sodium hyaluronate providing excellent humectant action and Lactobacillus Acerola Cherry Ferment offering antioxidant benefits.
- The product also contains Saccharomyces Ferments which support skin health and hydration, making it a good choice for your dry or flaky skin.
- The safety profile is excellent, with no risks of irritation for your dry and sensitive skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/goldfaden-md/radical-difference/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/goldfaden-md/radical-difference/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/goldfaden-md/radical-difference/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/goldfaden-md/radical-difference/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/goldfaden-md/radical-difference/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/goldfaden-md/radical-difference/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/goldfaden-md/radical-difference/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/goldfaden-md/radical-difference/for/dry-sensitive-skin): High (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/p/goldfaden-md/radical-difference/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Aspalathus Linearis Extract, Lactobacillus Acerola Cherry Ferment, Saccharomyces Zinc Ferment, Saccharomyces Magnesium Ferment

## What the research says

- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Ginkgo formulation increased skin moisturization by 27.88% and smoothness by 4.32% while reducing roughness by 0.4% and wrinkles by 4.63%, and significantly improved skin moisturization compared to the tea and rooibos formula. ([International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/20412217/))
- The addition of Aspalathus linearis extracts to topical sunscreen formulas containing OMC and BMDBM increased protection factors by up to 50% and protected the filters against photodegradation under radiation doses up to 14.4 standard erythemal doses. ([Photochemical & Photobiological Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/41591727/))
- The combination of fermented and unfermented Aspalathus linearis extracts showed a synergistic photoprotective effect on Normal Human Dermal Fibroblast survival after UVB radiation, which further improved when combined with Polypodium leucotomos extract. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40076948/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Goldfaden MD Radical Difference Advanced Antioxidant Serum a great fit for dry sensitive skin?

Goldfaden MD Radical Difference is a great fit because sodium hyaluronate draws in moisture to help soothe flaky areas while cherry ferment and rooibos extract provide antioxidants. It also contains various mineral ferments that support hydration and overall skin health. The formula has an excellent safety profile, so it is unlikely to cause irritation on dry and sensitive skin.
Sources: [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Which ingredients make this serum a good fit for dry sensitive skin?

Sodium hyaluronate makes this serum a great fit because it brings deep moisture to dry skin, while lactobacillus acerola cherry ferment and rooibos extract provide soothing antioxidant benefits. These ingredients work together safely without harsh irritants, making it very gentle for sensitive skin.
Sources: [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### What does Hyaluronic Acid do for dry sensitive skin?

Hyaluronic acid is a great fit for dry, sensitive skin because it brings a large boost in hydration, making the skin feel soft and smooth while improving barrier function. It helps calm tightness and dryness, and is unlikely to cause irritation.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/)

### What does Roobos Extract do for dry sensitive skin?

Rooibos extract helps calm dry, sensitive skin by protecting against irritation and soothing redness. It brings antioxidants that support your skin barrier and keep it feeling soft and comfortable.
Sources: [Molecules, 2016](https://pubmed.ncbi.nlm.nih.gov/27706097/)

### Where does it go in a skincare routine for dry sensitive skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. It is unlikely to cause irritation on your dry and sensitive skin.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment first and following with your retinol. Because this product has a very safe profile and lacks harsh ingredients, it is unlikely to irritate dry or sensitive skin when combined this way.

### How often should I use it?

Use this treatment in your evening routine, applying it after your toner and before your moisturizer. It is very gentle and safe for your dry and sensitive skin, so you can use it every evening without worry.
Sources: [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/), [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can it clog pores, cause breakouts or purging for dry sensitive skin?

This treatment is unlikely to clog pores or cause breakouts for dry sensitive skin because it is free of heavy, pore-clogging ingredients. Its gentle formula helps keep skin calm and hydrated without irritation.
Sources: [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — $39.99 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin) — Superior fit — $53.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-sensitive-skin) — Superior fit — $16.75 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — $16.97 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — $28.05 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — $18.99 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Sodium Hyaluronate, Aspalathus Linearis Extract, Lactobacillus Acerola Cherry Ferment, Saccharomyces Zinc Ferment, Saccharomyces Magnesium Ferment, Saccharomyces Iron Ferment, Saccharomyces Silicon Ferment, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/goldfaden-md/radical-difference/for/dry-sensitive-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/goldfaden-md/radical-difference/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/goldfaden-md/radical-difference/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/goldfaden-md/radical-difference/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/goldfaden-md/radical-difference/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/goldfaden-md/radical-difference/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/goldfaden-md/radical-difference/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/goldfaden-md/radical-difference/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/goldfaden-md/radical-difference/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/goldfaden-md/radical-difference/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/goldfaden-md/radical-difference/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/goldfaden-md/radical-difference/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/goldfaden-md/radical-difference/for/dry-sensitive-skin