# glymed+ Oxygen Cream for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/glymed/oxygen-cream/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [glymed+](https://lovi.care/skincare/brands/glymed)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate hydration for your combination skin, as glycerin and Tropaeolum Majus Stem Extract provide humectant and barrier-enhancing benefits, though these are not specifically targeted for acne, blemishes, and breakouts.
- Hydrolyzed Candida Saitoana Extract and sake extract offer additional barrier support and general skin conditioning, which are beneficial but do not directly address your primary concerns.
- The product is safe for your acne-prone skin, with grapefruit peel oil and tocopheryl acetate providing soothing effects and no harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/glymed/oxygen-cream/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/p/glymed/oxygen-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/glymed/oxygen-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/glymed/oxygen-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/glymed/oxygen-cream/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/p/glymed/oxygen-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/glymed/oxygen-cream/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/glymed/oxygen-cream/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/glymed/oxygen-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Hydrolyzed Candida Saitoana Extract, Lactobacillus Wasabia Extract, Tetrahexyldecyl Ascorbate, Glycerin, Tocopheryl Acetate

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Isosaponarin isolated from wasabi leaf increased type I collagen production in human fibroblasts by up-regulating TbetaR-II and P4H expression. ([Journal of Natural Medicines, 2010](https://pubmed.ncbi.nlm.nih.gov/20349148/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/))

## Why other moisturizers fit acne-prone skin better

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35763437/))

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does GlyMed Plus Oxygen Cream work for acne-prone skin?

GlyMed Plus Oxygen Cream works reasonably well for acne-prone skin, providing moderate hydration and soothing effects through ingredients like glycerin and tocopheryl acetate, though it does not specifically target breakouts. A moisturizing treatment for this skin needs ingredients that directly address acne and blemishes while supporting hydration without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/)

### Which ingredients make this cream a good fit for acne-prone skin?

Glycerin, grapefruit peel oil, and tocopheryl acetate make this cream a safe fit by providing moderate hydration and soothing effects without harsh ingredients. However, because it lacks targeted ingredients for blemishes and breakouts, a product for this skin needs effective acne-fighting ingredients, soothing extracts, and lightweight hydrators that balance oil without causing irritation.
Sources: [Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/)

### What does Hydrolyzed Candida Saitoana Extract do for acne-prone skin?

Hydrolyzed Candida Saitoana Extract helps improve the look of acne-prone skin by supporting a clear and smooth texture. It is generally well-tolerated and may help keep pores from clogging, leaving your face feeling balanced.

### What does Lactobacillus Wasabia Extract do for acne-prone skin?

Lactobacillus Wasabia Extract helps calm acne-prone skin by soothing redness and balancing surface bacteria. This ingredient is unlikely to clog pores and works well to keep oily skin clear and smooth.

### Where does this cream go in a skincare routine for acne-prone skin?

This moisturizing treatment goes in your evening routine after cleansing and before your final moisturizer, or as your main moisturizer in the morning. Acne-prone skin works best with products that provide lightweight hydration while actively targeting breakouts and blemishes.

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying your retinol first, letting it absorb, and then following with the cream to help keep your skin soft while soothing potential irritation. Using a barrier-supporting moisturizer alongside retinol helps improve your skin recovery and overall treatment comfort.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment daily to help keep your skin soft and calm. For an average fit on acne-prone skin, a product of this type needs targeted blemish-fighting ingredients and oil-balancing actives to properly address breakouts.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream is unlikely to clog pores or cause breakouts on acne-prone skin, as it contains soothing ingredients with a safe profile and no harsh additives. However, because it only offers moderate hydration without ingredients specifically targeted for blemishes and breakouts, acne-prone skin usually needs a moisturizing treatment with blemish-fighting ingredients and oil-balancing benefits.
Sources: [Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/)

### Can I use this cream around the eyes or on my body?

This cream is safe to use on the body and around the eyes, as its soothing ingredients help condition the skin without causing irritation. However, acne-prone skin needs products with targeted ingredients that directly clear breakouts and blemishes.

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — $15.50 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/p/cosrx/advanced-snail-96-mucin-power-essence/for/acne-prone-skin) — Superior fit — $15.88 at Amazon
- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin) — Superior fit — $49.95 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — $15.60 at Amazon
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/p/d-alba/piedmont-waterfull-mild-sunscreen/for/acne-prone-skin) — Superior fit — $15.99 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Isodecyl Neopentanoate, Isononyl Isononanoate, Glycerin, Tropaeolum Majus Stem Extract, Polyacrylate Crosspolymer-6, Hydroxystearyl Glucoside, Hydrolyzed Candida Saitoana Extract, Sorbitol, Lactobacillus Wasabia Extract, Sake Extract, Tocopheryl Acetate, Tetrahexyldecyl Ascorbate, Hydroxystearyl Alcohol, Grapefruit Peel Oil, Sodium Phytate, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/glymed/oxygen-cream/for/acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/glymed/oxygen-cream/for/acne-prone-skin
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