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Eucerin Hyaluron-Filler Epigenetic Serum for acne-prone skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Eucerin Hyaluron-Filler Epigenetic Serum

Average

  • HighCombination Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for acne-prone skin; other moisturizers fit it better.

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate hydration and plumping for your combination skin, as Hyaluronic Acid and Glycerin effectively moisturize and smooth texture. Panthenol also provides supportive benefits for acne-prone skin.
  • While the formula is generally safe and free from harsh ingredients, it does not directly target your primary concerns of acne, blemishes, and breakouts.
  • The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

How to apply

  • Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
  • Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
  • Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
  • Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
  • Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.

People Say

★4.5Overall rating based on 1.6k+ reviews

Based on a very large amount of data, users consistently report that the serum provides an immediate boost of hydration, leaving skin feeling significantly smoother, softer, and more radiant. While many observed a reduction in fine lines and a "plumped" effect within a few weeks, a small minority experienced skin irritation or felt the anti-aging results were not visible enough to justify the price.

Highlights

  • Lightweight, fast absorption Mostly Mentioned
    • “texture is lightweight and absorbs rapidly without leaving any residue”
    • “soaks into skin lovely... doesn't feel greasy”
    • “light gel texture that transforms almost into water”
  • Layers well Often Mentioned
    • “layers really well under the makeup”
    • “didn't pill under my moisturizer”
    • “makes a great base under make-up”
  • Smoother, plumper skin Often Mentioned
    • “skin feels plumped and rejuvenated”
    • “texture of my skin was smoother”
    • “face feels firmer and appears more youthful”
  • Pleasant, subtle scent Sometimes Noted
    • “fragrance is subtle and fresh”
    • “smell is really refreshing and nice”
    • “scent is very light... not overpowering”
  • Radiant, fresh glow Sometimes Noted
    • “makes your skin look fresh and glowy”
    • “regained the sort of translucent quality”
    • “skin feels more radiant”
  • High price point Sometimes Noted
    • “slightly pricey but does what it says”
    • “expensive for the amount you get”
    • “not worth the full price tag”
  • Allergic reactions Rarely Noted
    • “terrible reaction... requiring prescription-level antihistamines”
    • “caused irritation and breakouts”
    • “left my skin red and itchy”
  • No visible results Rarely Noted
    • “haven't seen any massive difference”
    • “don't really think it is anything special”
    • “yet to see any results in appearance”
  • Scent too strong Rarely Noted
    • “smell is a bit too strong for me”
    • “has a slight fragrance... sensitive skin might not like”
    • “perfume is quite noticeable”

Sources: lovi.care, boots.com, superdrug.com, lookfantastic.com, sephora.co.uk, hometesterclub.com, and more

Questions and answers

How well does Eucerin Epigenetic Serum work for acne-prone skin?

Eucerin Hyaluron-Filler Epigenetic Serum works moderately well for acne-prone skin by offering good hydration and smooth texture through hyaluronic acid, glycerin, and panthenol, though it does not actively treat breakouts. A product of this type needs ingredients like niacinamide, soothing botanical extracts, and peptides to properly target acne while keeping the skin balanced and calm.

Clinical, Cosmetic and Investigational Dermatology, 2017The Journal of Dermatological Treatment, 2017

Which ingredients make this serum a good fit for acne-prone skin?

Glycerin and Hyaluronic Acid help moisturize and smooth texture, while Panthenol provides supportive benefits for acne-prone skin. Because it does not directly target breakouts, a product for this skin needs ingredients like Niacinamide and soothing plant extracts that manage blemishes while keeping moisture balanced without excess oil.

Clinical, Cosmetic and Investigational Dermatology, 2017The Journal of Dermatological Treatment, 2017

What does Water do for acne-prone skin?

Water-based hydration helps keep acne-prone skin balanced by providing essential moisture without adding excess oil. Proper hydration also helps reduce dryness and flakiness that can sometimes result from harsh acne treatments.

What does Glycerin do for acne-prone skin?

Glycerin helps keep acne-prone skin hydrated and calm without clogging pores or feeling heavy. It supports the skin barrier so it stays soft and smooth while handling everyday treatments.

The British Journal of Dermatology, 2008International Journal of Toxicology, 2019

Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine step, after cleansing and toning and before moisturizing, for simplicity and extra safety around sun exposure. Acne-prone skin needs a product that directly targets breakouts with ingredients like salicylic acid or benzoyl peroxide.

Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to hydrate your skin before adding retinol. This approach helps keep your skin soft and smooth while your skin adjusts to the retinol. Acne-prone skin of this type needs a product that directly targets blemishes and breakouts alongside gentle hydration.

Cutis, 2006

How often should I use this serum?

You can use this treatment in your evening routine daily, as Lovi routines place serums in the evening for simplicity and extra safety around sun exposure. The formula is safe for your skin with no risks of irritation, though an acne-prone skin type needs targeted ingredients that directly clear blemishes and breakouts.

Journal of Cosmetic Dermatology, 2020

Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to clog pores or cause breakouts because it is generally safe and free from harsh ingredients, though it also does not actively treat acne. Acne-prone skin needs products with ingredients that directly target breakouts and blemishes.

Can I use this serum around the eyes or on my body?

This serum is safe to use around the eyes, though the skin there is much thinner than on the body. While it helps keep skin smooth, an acne-prone skin type needs a product that specifically targets breakouts and blemishes with clarifying and soothing ingredients.

Surgical and Radiologic Anatomy, 2002Clinical, Cosmetic and Investigational Dermatology, 2017

Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol denat).

What the research says

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

    The Journal of Dermatological Treatment, 2017

  • A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.

    Journal of Cosmetic Dermatology, 2025

  • The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

    Journal of Cosmetic Dermatology, 2020

  • Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

    International Journal of Cosmetic Science, 2001

  • Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

    Journal of Drugs in Dermatology, 2012

  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011

  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022

  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

Why other moisturizers fit acne-prone skin better

  • Gluconolactone 14% solution significantly improved mild to moderate acne by reducing inflamed and non-inflamed lesions similarly to 5% benzoyl peroxide, but with fewer side-effects in 150 patients.

    The Australasian Journal of Dermatology, 1992

  • A Tris/Arg-formulated cleanser significantly decreased noninflammatory and inflammatory acne and pore size with keratotic plugs compared to an AEC/AC cleanser in male Thai subjects with mild to moderate acne over 4 weeks.

    Journal of Cosmetic Dermatology, 2020

  • Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

    Molecules, 2023

Ingredients

Water, Glycerin, Alcohol Denat, Hyaluronic Acid, Epicelline, Panthenol, Glyceryl Glucoside, Sodium Hydroxide, Phenoxyethanol, Parfum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play