# EPICUTIS lipid serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/epicutis/lipid-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [EPICUTIS](https://lovi.care/skincare/brands/epicutis)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other moisturizers fit it better.

## Why this fit

- Offers moderate benefits for redness and irritation as hyaluronic acid and Tsc Disodium Tetramethylhexadecenyl Succinoyl Cysteine provide hydration and soothing effects suitable for your sensitive skin.
- It is moderately suitable for your normal skin type due to the humectant action of hyaluronic acid and glycerin, which hydrate but may lack sufficient emollient ingredients for optimal results.
- The product is safe for your sensitive skin as it contains no harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/epicutis/lipid-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/oily-acne-prone-skin): High

## Key ingredients

Hyaluronic Acid, Glycerin, Propanediol, Pentylene Glycol, Tsc Disodium Tetramethylhexadecenyl Succinoyl Cysteine

## What the research says

- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/))
- A mixture of propanediol, xylitol, and caprylic acid demonstrated in vitro antimicrobial activity against C. acnes and S. aureus, reduced 5-alpha reductase expression, and decreased skin oiliness, porphyrin, and inflammatory lesions in participants over 28 days. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34771112/))
- Sustainable cosmetic products formulated with renewable PDO-based emulsifiers showed equivalent performance in sensory and moisturization evaluations compared to those formulated with petroleum-derived PEG-based emulsifiers. ([Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/29465392/))
- Exposure of epidermal full-thickness skin equivalents to a blend of betaine, pentylene glycol, Saccharomyces cerevisiae, and Rhodiola rosea root extract significantly increased antioxidant, skin barrier, and oxidative stress biomarkers while reducing the negative impact of hydrogen peroxide on MMP3, MMP12, FBN2, ANXA1, and HGF, whereas a blend of Narcissus tazetta bulb extract and Schisandra chinensis fruit extract significantly increased 8 growth factors, 7 signaling, 7 structural/barrier function, 7 oxidative stress biomarkers, and specific microRNAs over control levels. ([International Journal of Molecular Sciences, 2018](https://pubmed.ncbi.nlm.nih.gov/30373163/))

## What reviewers say

Based on limited data, users highly recommend this serum for its ability to soothe redness and inflammation, deeply hydrate, and repair the skin barrier.

- Liked: Calms redness inflammation (mostly mentioned)
- Disliked: Expensive price tag (mostly mentioned)
- Liked: Deeply hydrating (often mentioned)
- Liked: Repairs skin barrier (often mentioned)
- Liked: Minimalist clean formula (sometimes noted)
- Disliked: Packaging dropper issues (rarely noted)
- Disliked: Rare breakouts (rarely noted)
- Disliked: Texture pilling (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does EPICUTIS Lipid Serum work for sensitive skin?

This serum works moderately well for sensitive skin because hyaluronic acid and Tsc Disodium Tetramethylhexadecenyl Succinoyl Cysteine help calm redness and irritation, though it lacks enough smoothing ingredients for optimal results. A product for this skin needs richer soothing components, multiple types of hyaluronic acid, and plant extracts to lock in moisture and maintain a healthy glow.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for sensitive skin?

Hyaluronic acid and Tsc Disodium Tetramethylhexadecenyl Succinoyl Cysteine make this serum a good fit for sensitive skin by providing hydration and soothing effects that help calm redness and irritation. Because this is an average fit, a product of this type needs richer soothing extracts, peptides, and multiple types of hyaluronic acid for optimal results.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### What does Glycerin do for sensitive skin?

Glycerin helps keep sensitive skin soft and deeply hydrated while supporting the skin barrier. It is unlikely to cause irritation and may protect against dryness and roughness.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Acta Dermato-venereologica, 1999](https://pubmed.ncbi.nlm.nih.gov/10598752/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in the evening routine for sensitive skin, applied after the soothing toner and before the moisturizer. Putting treatments in the evening keeps things simple and avoids extra safety concerns around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to hydrate your sensitive skin, followed by your retinol. This product provides moderate hydration to calm redness, but sensitive skin also needs nourishing oils and rich softeners to truly lock in moisture.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine, or twice a day if your skin tolerates it well. Daily application helps improve skin moisture and barrier function.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin, as it contains no harsh or prohibited ingredients that typically trigger irritation. However, a product of this type needs richer softening ingredients to fully support normal skin without feeling too light.

### Can I use this serum around the eyes or on my body?

You can safely use this serum around the eyes and on the body because it contains no harsh or prohibited ingredients for sensitive skin. A product of this type needs rich smoothing and softening ingredients to properly care for thin or body skin.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/sensitive-skin) — High fit — $30.00 at Amazon
- [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/p/isntree/green-tea-fresh-serum/for/sensitive-skin) — High fit — $17.90 at Amazon
- [Revision Skincare Hydrating Serum](https://lovi.care/skincare/p/revision-skincare/hydrating-serum/for/sensitive-skin) — High fit — $109.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — $28.08 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — $28.05 at Amazon
- Moisturizer with Sun Protection: [innisfree Daily Mild Sunscreen](https://lovi.care/skincare/p/innisfree/daily-mild-sunscreen/for/sensitive-skin) — Superior fit — $18.00 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Propanediol, Pentylene Glycol, Glycerin, Hyaluronic Acid, Tsc Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentasodium Pentetate, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/epicutis/lipid-serum/for/sensitive-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/epicutis/lipid-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/epicutis/lipid-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/epicutis/lipid-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/epicutis/lipid-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/epicutis/lipid-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/epicutis/lipid-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/epicutis/lipid-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/epicutis/lipid-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/epicutis/lipid-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/epicutis/lipid-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/epicutis/lipid-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/epicutis/lipid-serum/for/sensitive-skin