# EPICUTIS lipid serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/epicutis/lipid-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [EPICUTIS](https://lovi.care/skincare/brands/epicutis)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other moisturizers fit it better.

## Why this fit

- Offers moderate benefits for wrinkles and fine lines, as the hyaluronic acid and glycerin provide essential hydration and plumping effects suitable for your normal skin.
- The formulation is highly compatible with normal skin due to the humectant properties of hyaluronic acid and glycerin, which effectively hydrate and support skin barrier function.
- The product is safe for your skin, with no identified risks of irritation due to the absence of harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/epicutis/lipid-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/p/epicutis/lipid-serum/for/oily-acne-prone-skin): High

## Key ingredients

Hyaluronic Acid, Glycerin, Propanediol, Pentylene Glycol, Tsc Disodium Tetramethylhexadecenyl Succinoyl Cysteine

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/))
- A mixture of propanediol, xylitol, and caprylic acid demonstrated in vitro antimicrobial activity against C. acnes and S. aureus, reduced 5-alpha reductase expression, and decreased skin oiliness, porphyrin, and inflammatory lesions in participants over 28 days. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34771112/))
- Sustainable cosmetic products formulated with renewable PDO-based emulsifiers showed equivalent performance in sensory and moisturization evaluations compared to those formulated with petroleum-derived PEG-based emulsifiers. ([Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/29465392/))
- Exposure of epidermal full-thickness skin equivalents to a blend of betaine, pentylene glycol, Saccharomyces cerevisiae, and Rhodiola rosea root extract significantly increased antioxidant, skin barrier, and oxidative stress biomarkers while reducing the negative impact of hydrogen peroxide on MMP3, MMP12, FBN2, ANXA1, and HGF, whereas a blend of Narcissus tazetta bulb extract and Schisandra chinensis fruit extract significantly increased 8 growth factors, 7 signaling, 7 structural/barrier function, 7 oxidative stress biomarkers, and specific microRNAs over control levels. ([International Journal of Molecular Sciences, 2018](https://pubmed.ncbi.nlm.nih.gov/30373163/))

## What reviewers say

Based on limited data, users highly recommend this serum for its ability to soothe redness and inflammation, deeply hydrate, and repair the skin barrier.

- Liked: Calms redness inflammation (mostly mentioned)
- Disliked: Expensive price tag (mostly mentioned)
- Liked: Deeply hydrating (often mentioned)
- Liked: Repairs skin barrier (often mentioned)
- Liked: Minimalist clean formula (sometimes noted)
- Disliked: Packaging dropper issues (rarely noted)
- Disliked: Rare breakouts (rarely noted)
- Disliked: Texture pilling (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does EPICUTIS Lipid Serum work for mature skin?

This serum works moderately well for mature skin, as hyaluronic acid and glycerin provide essential hydration and plumping to help smooth fine lines. A product of this type needs intense hydration along with peptides, natural extracts, or fermented ingredients to better support mature skin vitality and radiance.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which ingredients make this serum a good fit for mature skin?

Hyaluronic acid and glycerin make this serum a good fit by providing essential hydration and plumping effects that help smooth fine lines. A moisturizing treatment for mature skin needs powerful hydrating ingredients like hyaluronic acid and glycerin, alongside peptides and natural extracts to support skin health and radiance.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this serum go in a skincare routine for mature skin?

Apply this serum in your evening routine after cleansing and toning, and before your moisturizer. Mature skin needs a moisturizing treatment with ingredients like hyaluronic acid and glycerin to provide essential hydration and plumping effects.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to hydrate and support your skin before applying retinol. This helps keep your skin comfortable and is unlikely to cause irritation.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this serum?

You can use this treatment in your evening routine, as treatments with active ingredients are typically placed at night for simplicity and safety around sun exposure. Some serums may also be used in the morning or twice a day depending on your skin's tolerance.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it contains no harsh ingredients and has a very low risk of breakouts. A product for this skin needs nourishing lipids and antioxidants like ceramides and peptides to smooth lines and better support firmness.

### Can I use this serum around the eyes or on my body?

You can safely use this serum around the eyes and on the body because it is gentle and well-tolerated. However, mature skin needs targeted ingredients like low molecular weight heparan sulfate or specialized botanical extracts to properly care for thinner areas and signs of aging.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30636356/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Revision Skincare Hydrating Serum](https://lovi.care/skincare/p/revision-skincare/hydrating-serum/for/mature-skin) — High fit — $109.00 at Amazon
- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/mature-skin) — High fit — $30.00 at Amazon
- [su:m37º Secret Essence Double Concentrate](https://lovi.care/skincare/p/su-m37o/secret-essence-double-concentrate/for/mature-skin) — High fit — $29.99 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — $46.00 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Propanediol, Pentylene Glycol, Glycerin, Hyaluronic Acid, Tsc Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentasodium Pentetate, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/epicutis/lipid-serum/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/epicutis/lipid-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/epicutis/lipid-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/epicutis/lipid-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/epicutis/lipid-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/epicutis/lipid-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/epicutis/lipid-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/epicutis/lipid-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/epicutis/lipid-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/epicutis/lipid-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/epicutis/lipid-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/epicutis/lipid-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/epicutis/lipid-serum/for/mature-skin