# Eighth Day Regenerative Serum for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/p/eighth-day/regenerative-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Eighth Day](https://lovi.care/skincare/brands/eighth-day)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your combination skin, as niacinamide helps regulate oil production and sodium hyaluronate provides hydration, though it does not directly target acne and blemishes.
- The serum's multiple peptides, such as Sh-Oligopeptide-2 and Palmitoyl Tripeptide-5, are excellent for skin regeneration and smoothing texture, which can indirectly support clearer skin.
- The product is generally safe for your combination skin, with a low risk of irritation from glycolic acid.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/eighth-day/regenerative-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/eighth-day/regenerative-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/eighth-day/regenerative-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/eighth-day/regenerative-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/eighth-day/regenerative-serum/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/p/eighth-day/regenerative-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/eighth-day/regenerative-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/eighth-day/regenerative-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/eighth-day/regenerative-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Peptide-Rich Plasma, Sodium Hyaluronate, Niacinamide, Acetyl Glutamine, Manuka Honey

## What the research says

- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Topical insulin combined with fractional CO2 laser showed no significant difference in efficacy compared to topical PRP combined with fractional CO2 laser for atrophic acne scars in 30 patients. ([Archives of Dermatological Research, 2025](https://pubmed.ncbi.nlm.nih.gov/40167803/))
- Subcision and microneedling combined with topical platelet-rich plasma resulted in significantly greater improvement in scar grading compared to subcision and microneedling alone in patients with atrophic scars. ([Journal of Cutaneous and Aesthetic Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/38800810/))
- Platelets remain viable for up to 90 days in a refrigerated cosmetic vehicle with demonstrated topical clinical PRP facial benefits, and 20ml and 60ml PRP volumes are equally efficacious. ([Journal of Drugs in Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33346518/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical overnight application of MGO Manuka Honey microemulsion eye cream significantly reduced symptomology, improved tear film stability and lipid layer thickness, and decreased lid margin staining, ocular Demodex, and bacterial load in patients with blepharitis compared to control eyes. ([The Ocular Surface, 2020](https://pubmed.ncbi.nlm.nih.gov/31759183/))
- Optimel 16% manuka honey eye-drops significantly improved symptoms and objective signs in patients with meibomian gland dysfunction compared to baseline after 3 weeks. ([The British Journal of Ophthalmology, 2022](https://pubmed.ncbi.nlm.nih.gov/33419788/))
- The application of Manuka honey and the GENADYNE A4 negative pressure wound therapy system in a 55-year-old woman with extensive phlegmonous and necrotic lesions following traumatic colonic rupture successfully enabled skin autografting and complete wound healing. ([Medical Science Monitor, 2010](https://pubmed.ncbi.nlm.nih.gov/20980964/))

## Why other serums fit acne-prone skin better

- Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

This serum is highly praised for its "Peptide-Rich Plasma" technology, which users credit for rapidly improving skin texture, firmness, and radiance. While many describe it as a "holy grail" for anti-aging and hydration, a subset of users feel the high price tag is not justified by the results, which can be subtle for some.

- Disliked: High price (mostly mentioned)
- Liked: Fast absorption (often mentioned)
- Liked: Visible anti-aging (often mentioned)
- Liked: High-tech ingredients (sometimes noted)
- Liked: Hydration (sometimes noted)
- Disliked: Lack of results (sometimes noted)
- Liked: Packaging (rarely noted)
- Disliked: Availability issues (rarely noted)
- Disliked: No acne benefit (rarely noted)
- Disliked: Texture complaints (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Eighth Day Regenerative Serum work for acne-prone skin?

Eighth Day Regenerative Serum works moderately well for acne-prone skin, as niacinamide helps control oil and peptides smooth texture, though it does not directly target breakouts. To work best for this skin, a treatment needs ingredients like niacinamide and zinc PCA to target blemishes while balancing hydration and oil without irritation.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Which ingredients make this serum a good fit for acne-prone skin?

Niacinamide helps regulate oil production, while multiple peptides smooth texture to support clearer skin, and sodium hyaluronate provides hydration. To best fit acne-prone skin, a treatment of this type needs targeted ingredients like propolis or zinc PCA for blemishes, along with balancing hydrators that control oil without causing dryness.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/)

### What does Peptide-Rich Plasma do for acne-prone skin?

Platelet-rich plasma helps calm inflamed acne lesions and improves the look of acne scars when used alongside in-office treatments like lasers or microneedling. Combining these methods is unlikely to cause extra downtime and may boost collagen production for smoother skin.
Sources: [Lasers in Medical Science, 2022](https://pubmed.ncbi.nlm.nih.gov/35084634/), [Dermatologic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24354616/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine, after cleansing and before moisturizing, to keep things simple and safe around sun use. For this skin, a product of this type needs soothing and oil-controlling ingredients like niacinamide and salicylic acid to help clear breakouts.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following with your retinol to help smooth texture while managing potential irritation. This combination is generally safe, though a product of this type for acne-prone skin also needs ingredients that directly target breakouts and blemishes.

### How often should I use this serum?

Use this serum in the evening. Acne-prone skin needs a treatment that directly targets breakouts and blemishes with ingredients like salicylic acid or benzoyl peroxide.

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to cause breakouts on acne-prone skin, as niacinamide helps control oil and the overall formula is generally safe. However, because it does not directly target blemishes, acne-prone skin often needs products packed with clarifying ingredients like salicylic acid or benzoyl peroxide to truly keep pores clear.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — $28.88 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — $39.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — $15.60 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — $15.50 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentylene Glycol, Peptide-Rich Plasma, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Acetyl Hexapeptide-8, Sh-Oligopeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Acetyl Glutamine, Sodium Hyaluronate, Lysine Hcl, Alanine, Histidine Hcl, Arginine, Serine, Proline, Glutamic Acid, Threonine, Valine, Leucine, Glycine, Isoleucine, Phenylalanine, Taurine, Glycerin, Hedychium Coronarium Root Extract, Tripeptide-1, Polygonum Aviculare Extract, Honey, Nonapeptide-1, Acetyl Heptapeptide-4, Phytosphingosine, Sea Whip Extract, Niacinamide, Hydrolyzed Hyaluronic Acid, Aminobutyric Acid, Adenosine, Thioctic Acid, Glycolic Acid, Bacillus Soybean Folic Acid Extract Ferment, Polysorbate 20, Allantoin, Caprylyl Glycol, Lecithin, Butylene Glycol, 1,2-Hexanediol, Dextran, Phenoxyethanol, Ethylhexylglycerin, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/eighth-day/regenerative-serum/for/acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/eighth-day/regenerative-serum/for/acne-prone-skin
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