# Drunk Elephant Protini Polypeptide Cream for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: Superior · Safety: High.

Page: https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Drunk Elephant](https://lovi.care/skincare/brands/drunk-elephant)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Excellent suitability for your normal skin is provided by multiple peptides, such as Sh-Oligopeptide-1 and Sh-Oligopeptide-2, which work synergistically to stimulate collagen synthesis and improve skin elasticity, effectively addressing your concerns about wrinkles and fine lines.
- Hyaluronic acid and a blend of amino acids further enhance the formula by providing superior hydration and supporting skin barrier function, ensuring a plump and smooth complexion.
- The product is safe for your skin, featuring a gentle formulation with soothing ingredients like hyaluronic acid and peptides, and contains no harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin): Superior
- [Sensitive skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/oily-acne-prone-skin): High

## Key ingredients

9 Signal Peptides, Pygmy Waterlily, Sodium Hyaluronate, Glycerin, Copper Palmitoyl Heptapeptide-14

## What the research says

- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG. ([Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/))
- Water lily rhizome extract protected human epidermal keratinocytes against UVB-induced mitochondria-mediated apoptosis by reducing reactive oxygen species generation, mitochondrial dysfunction, and apoptotic signaling while increasing antiapoptotic proteins and antioxidant levels. ([Pharmacology, 2016](https://pubmed.ncbi.nlm.nih.gov/26915077/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))

## What reviewers say

Based on a very large amount of data, this moisturizer is frequently praised for its lightweight, non-greasy texture that firms and plumps the skin, making it a favorite for combination and oily skin types. It also performs well under makeup and is generally well-tolerated by sensitive skin. However, some users with very dry skin find it lacks sufficient hydration, and a significant number of reviews mention the high price point as a drawback.

- Liked: Lightweight texture (mostly mentioned)
- Disliked: High price (mostly mentioned)
- Liked: Hygienic packaging (often mentioned)
- Liked: Makeup compatibility (sometimes noted)
- Liked: Sensitive skin friendly (sometimes noted)
- Liked: Visible results (sometimes noted)
- Disliked: Dry skin hydration (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Drunk Elephant Protini Polypeptide Cream one of the best fits for mature skin?

This cream is one of the best fits for mature skin because multiple peptides help boost firmness and smooth out fine lines, while hyaluronic acid and amino acids provide deep hydration to keep your complexion plump and soft. It is also very gentle on the skin with a safe formula that avoids harsh ingredients.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/)

### Which ingredients make this cream a good fit for mature skin?

This cream is a great fit for mature skin because it contains multiple peptides that help boost collagen and improve elasticity to smooth out fine lines and wrinkles. It also includes sodium hyaluronate and amino acids that provide deep hydration and support your skin barrier for a plump, soft feel.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/)

### What do Signal Peptides do for mature skin?

Signal peptides help mature skin by supporting collagen production, which smooths out fine lines and wrinkles while improving firmness and elasticity. Applying them daily may also increase skin hydration and help the skin look and feel more youthful.
Sources: [Journal of Drugs in Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27050701/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37335808/)

### What does Pygmy Waterlily do for mature skin?

Pygmy waterlily helps protect mature skin from daily sun damage and aging by fighting off harmful reactive oxygen species and reducing stress in skin cells. This plant extract is unlikely to cause irritation and may support your skin in staying smooth and healthy.
Sources: [Pharmacology, 2016](https://pubmed.ncbi.nlm.nih.gov/26915077/)

### Where does this cream go in a skincare routine for mature skin?

This moisturizing treatment goes after your toner and before your sunscreen in the morning, and after your cleansing toner and treatment in the evening. Using it daily helps keep mature skin plump, smooth, and well-hydrated.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol, and applying it after your retinol helps keep your skin calm and comfortable. This pairing is unlikely to cause irritation because the gentle formula features soothing ingredients like peptides and hyaluronic acid.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### How often should I use this cream?

This cream is well suited for daily use, and applying it twice a day helps keep mature skin plump and smooth. Regular use of moisturizers with peptides and hyaluronic acid is very likely to improve hydration, fine lines, and overall elasticity over time.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin, as it features a gentle formula with soothing ingredients and carries a low complaint rate for causing breakouts. It helps keep skin smooth and soft while supporting a healthy skin barrier.
Sources: [Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Can I use this cream around the eyes or on my body?

This moisturizing treatment is well suited for the thin skin around the eyes and body because its gentle peptides and hyaluronic acid hydrate deeply and improve elasticity without irritation. While the formula is safe and generally well tolerated, the delicate eye area may require careful application to avoid direct contact.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30636356/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon
- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/mature-skin) — Superior fit — $22.00 at Amazon
- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — $120.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — $46.00 at Amazon

## Where to buy

- Amazon.com: $49.95 (https://www.amazon.com/dp/B07934S6WK?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Dicaprylyl Carbonate, Glycerin, Cetearyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Sclerocarya Birrea Seed Oil, Bacillus Folic Acid Extract Ferment, Nymphaea Alba Root Extract, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Alanine, Arginine, Glycine, Histidine, Isoleucine, Phenylalanine, Proline, Serine, Threonine, Valine, Acetyl Glutamine, Coconut Alkanes, Coco-Caprylate Caprate, Sodium Hyaluronate, Aspartic Acid, Linoleic Acid, Linolenic Acid, Lecithin, Butylene Glycol, Polyvinyl Alcohol, Sodium Lactate, Sodium Pca, Pca, Sorbitan Isostearate, Carbomer, Polysorbate 20, Polysorbate 60, Lactic Acid Glycolic Acid Copolymer, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Xanthan Gum, Isomalt, 1,2-Hexanediol, Caprylyl Glycol, Chlorphenesin, Phenoxyethanol, Tocopherol, Sodium Benzoate, Phenylpropanol, Glyceryl Caprylate, Symphytum Officinale Callus Culture Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin