# Drunk Elephant Protini Polypeptide Cream for dry sensitive skin

**Lovi Fit: Superior fit for dry sensitive skin.**
Dry Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Drunk Elephant](https://lovi.care/skincare/brands/drunk-elephant)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for dry sensitive skin.

## Why this fit

- Excellent suitability for your dry and sensitive skin is provided by the high concentration of multiple peptides like Sh-Oligopeptide-1 and Sh-Oligopeptide-2, which are known for their skin-restoring and plumping properties, alongside humectants such as glycerin and sodium hyaluronate that deeply hydrate and smooth the skin.
- The inclusion of Sclerocarya Birrea Seed Oil and Linoleic Acid further nourishes and supports your skin barrier, enhancing overall comfort and suppleness.
- This formula is safe for your skin, as it contains no harsh ingredients and is formulated with soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin): Superior
- [Sensitive skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin): Superior (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/oily-acne-prone-skin): High

## Key ingredients

9 Signal Peptides, Pygmy Waterlily, Sodium Hyaluronate, Glycerin, Copper Palmitoyl Heptapeptide-14

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of Sclerocarya birrea nut oil is non-irritant, exhibits significant moisturising and hydrating effects on lipid-dry skin, and shows occlusive properties on normal skin in healthy caucasian adult female volunteers. ([Journal of Ethnopharmacology, 2015](https://pubmed.ncbi.nlm.nih.gov/26528587/))
- Water lily rhizome extract protected human epidermal keratinocytes against UVB-induced mitochondria-mediated apoptosis by reducing reactive oxygen species generation, mitochondrial dysfunction, and apoptotic signaling while increasing antiapoptotic proteins and antioxidant levels. ([Pharmacology, 2016](https://pubmed.ncbi.nlm.nih.gov/26915077/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, this moisturizer is frequently praised for its lightweight, non-greasy texture that firms and plumps the skin, making it a favorite for combination and oily skin types. It also performs well under makeup and is generally well-tolerated by sensitive skin. However, some users with very dry skin find it lacks sufficient hydration, and a significant number of reviews mention the high price point as a drawback.

- Liked: Lightweight texture (mostly mentioned)
- Disliked: High price (mostly mentioned)
- Liked: Hygienic packaging (often mentioned)
- Liked: Makeup compatibility (sometimes noted)
- Liked: Sensitive skin friendly (sometimes noted)
- Liked: Visible results (sometimes noted)
- Disliked: Dry skin hydration (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using this moisturizer 3 times a week and move to daily use if your dry skin tolerates it well.
- Apply this moisturizer after cleansing and toner in the morning, or after your serum in the evening. Always pair it with SPF in the morning.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it harshly to protect your sensitive skin.
- Apply the moisturizer on slightly damp skin to help with hydration absorption. This also works well for dry and flaky skin types.
- Do a patch test before your first use. Avoid the eye area to prevent any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Drunk Elephant Protini Polypeptide Cream one of the best fits for dry sensitive skin?

This cream is an exceptional fit for dry sensitive skin because it combines multiple peptides that plump and restore the skin with glycerin and sodium hyaluronate to deeply hydrate and smooth dry areas. Additionally, marula oil and linoleic acid nourish the skin barrier to enhance comfort without causing irritation.
Sources: [Journal of Ethnopharmacology, 2015](https://pubmed.ncbi.nlm.nih.gov/26528587/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for dry sensitive skin?

This cream is a great fit for your dry sensitive skin due to multiple peptides that plump and restore, alongside glycerin and sodium hyaluronate which deeply hydrate and smooth the skin. Additionally, marula seed oil and linoleic acid nourish and support your skin barrier for enhanced comfort.
Sources: [Journal of Ethnopharmacology, 2015](https://pubmed.ncbi.nlm.nih.gov/26528587/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What do Signal Peptides do for dry sensitive skin?

Signal peptides help make dry sensitive skin feel firmer and look smoother while supporting a strong skin barrier. This type of skin needs soothing ingredients like ceramides, panthenol, and plant extracts alongside peptides to calm irritation and lock in moisture safely.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41450017/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40682399/)

### What does Pygmy Waterlily do for dry sensitive skin?

Pygmy Waterlily helps calm dry sensitive skin by providing antioxidant protection against environmental stress and supporting skin comfort. This ingredient is unlikely to cause irritation and works to keep skin feeling soft and smooth.
Sources: [Pharmacology, 2016](https://pubmed.ncbi.nlm.nih.gov/26915077/)

### Where does this cream go in a skincare routine for dry sensitive skin?

This moisturizing treatment goes in the evening routine, after your soothing toner and before your moisturizer. Lovi routines put treatments in the evening for simplicity and extra safety around sun exposure.

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying your retinol first and following with this moisturizer to help keep your dry, sensitive skin calm and comfortable. Using a gentle moisturizer alongside retinoids is unlikely to cause irritation and helps support your skin barrier while it adjusts.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this cream?

This cream is well suited for your dry sensitive skin and can be used in your evening routine. Daily application helps deeply hydrate and smooth your skin while supporting your skin barrier for enhanced comfort.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for dry sensitive skin?

This cream is unlikely to clog pores or cause breakouts for dry sensitive skin, as its gentle formula contains soothing ingredients and no harsh additives. Reviewers also report a low rate of breakouts.

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on the body because its gentle peptide and glycerin formula helps hydrate and smooth delicate areas. The skin around the eyes and on the body is thin and prone to dryness, so it benefits greatly from the deep moisture and soothing care provided by this cream.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Journal of Ethnopharmacology, 2015](https://pubmed.ncbi.nlm.nih.gov/26528587/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry sensitive skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/dry-sensitive-skin) — Superior fit — $22.00 at Amazon
- [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/dry-sensitive-skin) — Superior fit — $85.00 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/p/the-ordinary/natural-moisturizing-factors-ha/for/dry-sensitive-skin) — Superior fit — $12.50 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — $16.97 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — $28.05 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $49.95 (https://www.amazon.com/dp/B07934S6WK?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Dicaprylyl Carbonate, Glycerin, Cetearyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Sclerocarya Birrea Seed Oil, Bacillus Folic Acid Extract Ferment, Nymphaea Alba Root Extract, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Alanine, Arginine, Glycine, Histidine, Isoleucine, Phenylalanine, Proline, Serine, Threonine, Valine, Acetyl Glutamine, Coconut Alkanes, Coco-Caprylate Caprate, Sodium Hyaluronate, Aspartic Acid, Linoleic Acid, Linolenic Acid, Lecithin, Butylene Glycol, Polyvinyl Alcohol, Sodium Lactate, Sodium Pca, Pca, Sorbitan Isostearate, Carbomer, Polysorbate 20, Polysorbate 60, Lactic Acid Glycolic Acid Copolymer, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Xanthan Gum, Isomalt, 1,2-Hexanediol, Caprylyl Glycol, Chlorphenesin, Phenoxyethanol, Tocopherol, Sodium Benzoate, Phenylpropanol, Glyceryl Caprylate, Symphytum Officinale Callus Culture Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin