# Drunk Elephant Protini Polypeptide Cream for combination skin

**Lovi Fit: Superior fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Superior · Safety: High.

Page: https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Drunk Elephant](https://lovi.care/skincare/brands/drunk-elephant)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for combination skin.

## Why this fit

- Excellent for your combination skin, this formula leverages multiple peptides like Sh-Oligopeptide-1 and Sh-Oligopeptide-2 to promote skin regeneration and improve texture, while Lactic Acid Glycolic Acid Copolymer helps manage oiliness and reduce shine.
- The inclusion of glycerin and sodium hyaluronate provides essential hydration without feeling heavy, supporting your skin's barrier function and collagen stimulation.
- This product is safe for your skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin): Superior (this page)
- [Sensitive skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/oily-acne-prone-skin): High

## Key ingredients

9 Signal Peptides, Pygmy Waterlily, Sodium Hyaluronate, Glycerin, Copper Palmitoyl Heptapeptide-14

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Water lily rhizome extract protected human epidermal keratinocytes against UVB-induced mitochondria-mediated apoptosis by reducing reactive oxygen species generation, mitochondrial dysfunction, and apoptotic signaling while increasing antiapoptotic proteins and antioxidant levels. ([Pharmacology, 2016](https://pubmed.ncbi.nlm.nih.gov/26915077/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, this moisturizer is frequently praised for its lightweight, non-greasy texture that firms and plumps the skin, making it a favorite for combination and oily skin types. It also performs well under makeup and is generally well-tolerated by sensitive skin. However, some users with very dry skin find it lacks sufficient hydration, and a significant number of reviews mention the high price point as a drawback.

- Liked: Lightweight texture (mostly mentioned)
- Disliked: High price (mostly mentioned)
- Liked: Hygienic packaging (often mentioned)
- Liked: Makeup compatibility (sometimes noted)
- Liked: Sensitive skin friendly (sometimes noted)
- Liked: Visible results (sometimes noted)
- Disliked: Dry skin hydration (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Drunk Elephant Protini Polypeptide Cream one of the best fits for combination skin?

This cream is an excellent fit for combination skin because it uses multiple peptides to improve texture and regeneration while copolymers help manage oiliness and reduce shine. Ingredients like glycerin and sodium hyaluronate provide essential hydration without feeling heavy, supporting your skin barrier.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for combination skin?

This cream is a great fit for combination skin because it uses multiple peptides to improve texture and regeneration, along with a copolymer to help manage oiliness and reduce shine. Ingredients like glycerin and sodium hyaluronate also provide essential hydration without feeling heavy.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What do Signal Peptides do for combination skin?

Signal peptides help firm combination skin and smooth out fine lines by encouraging the skin to build fresh collagen and keep its structure strong. This type of skin needs ingredients that support firmness and hydration without feeling heavy.
Sources: [PloS One, 2025](https://pubmed.ncbi.nlm.nih.gov/40880343/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### What does Pygmy Waterlily do for combination skin?

Pygmy Waterlily helps protect combination skin by fighting cell damage from environmental stress and supporting healthy skin cells. This plant extract is unlikely to irritate and may help keep your skin looking calm and balanced.
Sources: [Pharmacology, 2016](https://pubmed.ncbi.nlm.nih.gov/26915077/)

### Where does this cream go in a skincare routine for combination skin?

This cream goes in the moisturizer step of your morning and evening routine, after your hydrating toner or treatment. It provides lightweight hydration that supports your skin barrier without feeling heavy, and it is unlikely to cause irritation.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol by applying the retinol first and following it with this moisturizer. This combination helps keep your skin hydrated and supports its barrier while you use retinoids.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

This cream is designed for daily use as part of your morning and evening routine. Regular application helps maintain skin hydration and texture without feeling heavy.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to cause breakouts for combination skin, as review complaints about breakouts are low and the formula avoids harsh ingredients that typically trigger irritation. Glycerin and sodium hyaluronate provide lightweight hydration to help keep your skin balanced.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on the body because its gentle, hydrating formula works safely on thin areas like the eyelids and across various body regions. Glycerin and sodium hyaluronate provide essential moisture and support the skin barrier without feeling heavy.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/combination-skin) — Superior fit — $15.50 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/p/the-ordinary/natural-moisturizing-factors-ha/for/combination-skin) — High fit — $12.50 at Amazon
- [Anua Heartleaf 78% Soothing Cream](https://lovi.care/skincare/p/anua/heartleaf-78-soothing-cream/for/combination-skin) — High fit — $25.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — $25.60 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — $14.97 at Amazon

## Where to buy

- Amazon.com: $49.95 (https://www.amazon.com/dp/B07934S6WK?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Dicaprylyl Carbonate, Glycerin, Cetearyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Sclerocarya Birrea Seed Oil, Bacillus Folic Acid Extract Ferment, Nymphaea Alba Root Extract, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Alanine, Arginine, Glycine, Histidine, Isoleucine, Phenylalanine, Proline, Serine, Threonine, Valine, Acetyl Glutamine, Coconut Alkanes, Coco-Caprylate Caprate, Sodium Hyaluronate, Aspartic Acid, Linoleic Acid, Linolenic Acid, Lecithin, Butylene Glycol, Polyvinyl Alcohol, Sodium Lactate, Sodium Pca, Pca, Sorbitan Isostearate, Carbomer, Polysorbate 20, Polysorbate 60, Lactic Acid Glycolic Acid Copolymer, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Xanthan Gum, Isomalt, 1,2-Hexanediol, Caprylyl Glycol, Chlorphenesin, Phenoxyethanol, Tocopherol, Sodium Benzoate, Phenylpropanol, Glyceryl Caprylate, Symphytum Officinale Callus Culture Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin
- France: https://lovi.care/skincare/fr/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin