# Dermol 500 Lotion for mature skin

**Lovi Fit: Caution fit for mature skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: Concerning.

Page: https://lovi.care/skincare/p/dermol/500-lotion/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Dermol](https://lovi.care/skincare/brands/dermol)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A poor match for mature skin; the moisturizers alongside fit it better.

## Why this fit

- Offers moderate suitability for normal skin as liquid paraffin and isopropyl myristate provide emollient action, though the formula lacks sufficient humectants for optimal hydration.
- The product offers supportive benefits for wrinkles and fine lines due to the absence of specialized ingredients like retinoids or peptides that target collagen production.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/dermol/500-lotion/for/oily-skin): Warning
- [Dry skin](https://lovi.care/skincare/p/dermol/500-lotion/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/dermol/500-lotion/for/combination-skin): Caution
- [Sensitive skin](https://lovi.care/skincare/p/dermol/500-lotion/for/sensitive-skin): Caution
- [Acne-prone skin](https://lovi.care/skincare/p/dermol/500-lotion/for/acne-prone-skin): Caution
- [Skin with dark spots](https://lovi.care/skincare/p/dermol/500-lotion/for/dark-spots): Caution
- [Mature skin](https://lovi.care/skincare/p/dermol/500-lotion/for/mature-skin): Caution (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/dermol/500-lotion/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/p/dermol/500-lotion/for/oily-acne-prone-skin): Caution

## Key ingredients

Benzalkonium Chloride, Chlorhexidine Dihydrochloride, Liquid Paraffin, Isopropyl Myristate, Cetostearyl Alcohol

## What the research says

- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- Topical application of an intimate cleansing gel containing chlorhexidine, hyaluronic acid, and anti-inflammatory agents after ultrasound scalpel-assisted hemorrhoidectomy reduced pain and itching while accelerating complete wound healing at 4 weeks compared to washing with warm water alone in adult patients. ([Annals of Coloproctology, 2024](https://pubmed.ncbi.nlm.nih.gov/39748553/))
- Topical therapy with 4% chlorhexidine digluconate products resolved clinical signs in all dogs with superficial pyoderma, including those with meticillin-resistant strains, showing comparable efficacy to systemic amoxicillin-clavulanic acid. ([Veterinary Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26140535/))
- Repeated application of concentrated water-in-oil emulsions over four weeks caused no skin irritation, positively affected skin properties, and delivered almost 50% of the applied fluorescein sodium, with isopropyl myristate showing superior penetration performance compared to liquid paraffin in healthy volunteers. ([International Journal of Pharmaceutics, 2019](https://pubmed.ncbi.nlm.nih.gov/31525444/))
- Increasing the softness of pressure-sensitive adhesives using isopropyl myristate decreased pain and stripped corneocytes during removal without significantly changing human skin dermal peeling force. ([Skin Research and Technology, 2007](https://pubmed.ncbi.nlm.nih.gov/17374065/))
- A modern cold cream formulation using a self-emulsionable excipient with isopropyl myristate shows improved preparation ease, stability, rheological qualities, and moisture and emollient power compared to traditional cerates. ([Bollettino Chimico Farmaceutico, 1996](https://pubmed.ncbi.nlm.nih.gov/8942063/))

## What reviewers say

It is celebrated for its versatility as both a leave-on moisturizer and a soap substitute, providing rapid relief from itching and preventing secondary infections due to its antimicrobial properties.

- Liked: Versatile application (mostly mentioned)
- Liked: Excellent texture (often mentioned)
- Liked: Hand care (often mentioned)
- Liked: Rapid itch relief (often mentioned)
- Liked: Antimicrobial benefits (sometimes noted)
- Disliked: Adverse reactions (rarely noted)
- Disliked: Insufficient for dryness (rarely noted)
- Disliked: Medicinal scent (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Texture dislike (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### Why does Lovi advise caution with Dermol 500 Lotion for mature skin?

Lovi advises caution because this lotion lacks specialized ingredients like retinoids or peptides that target collagen production for wrinkles and fine lines, and it does not have enough water-attracting ingredients for deep hydration. A moisturizing treatment for mature skin needs multiple hydrating agents and soothing extracts to maintain skin balance and target signs of aging.

### Which ingredients make this lotion a poor fit for mature skin?

This lotion is a poor fit for mature skin because it lacks specialized ingredients like retinoids or peptides that target collagen production and smooth fine lines. A moisturizing treatment for mature skin needs active ingredients that boost collagen and richer hydrating agents to keep dry skin soft and plump.

### What does Benzalkonium Chloride do for mature skin?

Benzalkonium chloride does not provide anti-aging benefits for mature skin and may cause irritation or compromise the skin barrier with repeated use. Mature skin needs nourishing ingredients like antioxidants, peptides, and rich moisturizers to improve firmness and keep it soft and smooth.
Sources: [Regulatory Toxicology and Pharmacology, 2005](https://pubmed.ncbi.nlm.nih.gov/16099566/), [Dermatosen in Beruf und Umwelt. Occupation and Environment, 1985](https://pubmed.ncbi.nlm.nih.gov/4028973/)

### What does Chlorhexidine Dihydrochloride do for mature skin?

Chlorhexidine Dihydrochloride is an antiseptic agent that helps reduce bacteria on the skin, but it is not typically targeted for mature skin benefits. A product for mature skin needs nourishing ingredients and moisturizers that improve firmness, smooth fine lines, and keep dry skin soft.
Sources: [The Journal of Investigative Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29753031/)

### Where does it go in a skincare routine for mature skin?

This moisturizing treatment goes in the moisturizer step of your morning and evening routines. Mature skin needs products with ingredients like retinoids or peptides to help with wrinkles and fine lines, which this formula lacks.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this lotion with retinol, and in what order?

You can use this lotion with retinol, applying the lotion first to help keep your skin comfortable and smooth. Using a moisturizer like this helps support your skin barrier while you use retinol, though mature skin also needs ingredients like retinoids or peptides to help with fine lines.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use it?

This lotion is a poor match for mature skin because it lacks key anti-aging ingredients and deep hydration. Mature skin needs products with powerful hydrators and specialized ingredients like retinoids or peptides to boost collagen and smooth fine lines.

### Can this lotion clog pores, cause breakouts or purging for mature skin?

This lotion is unlikely to clog pores or cause breakouts for mature skin, though it may not provide enough rich moisture to keep dry mature skin feeling soft and smooth. A product of this type needs extra hydrators and firming ingredients like peptides or retinoids to properly care for mature skin.

### Can I use it around the eyes or on my body?

This lotion is a poor match for mature skin because it lacks specialized ingredients like retinoids or peptides that target collagen production. To care for mature skin around the eyes or on the body, a product of this type needs added hydrating ingredients and components that support firmness.

### Is this lotion fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [ROUND LAB Mugwort Calming Line](https://lovi.care/skincare/p/round-lab/mugwort-calming-line/for/mature-skin) — Average fit — $19.96 at Amazon

## Routine for mature skin

### AM

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — $46.00 at Amazon

### PM

- Pre-Cleanser: [Dermalogica PreCleanse](https://lovi.care/skincare/p/dermalogica/precleanse/for/mature-skin) — Superior fit — $49.00 at Amazon
- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Cleansing Toner: [Pixi Glow Tonic](https://lovi.care/skincare/p/pixi/glow-tonic/for/mature-skin) — Superior fit — $28.42 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/p/peach-and-lily/glass-skin-refining-serum/for/mature-skin) — Superior fit — $39.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon

### Weekly

- Pre-Cleanser: [Dermalogica PreCleanse](https://lovi.care/skincare/p/dermalogica/precleanse/for/mature-skin) — Superior fit — $49.00 at Amazon
- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Enzyme Powder: [Fancl Facial Washing Powder](https://lovi.care/skincare/p/fancl/facial-washing-powder/for/mature-skin) — Superior fit — $22.00 at Amazon
- Nourishing Mask: [MEDIHEAL Vita Essential Mask](https://lovi.care/skincare/p/mediheal/vita-essential-mask/for/mature-skin) — Superior fit — $22.00 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/p/peach-and-lily/glass-skin-refining-serum/for/mature-skin) — Superior fit — $39.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Benzalkonium Chloride, Chlorhexidine Dihydrochloride, Liquid Paraffin, Isopropyl Myristate, Cetostearyl Alcohol, Cetomacrogol 1000, Phenoxyethanol, Water
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/dermol/500-lotion/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/dermol/500-lotion/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/dermol/500-lotion/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/dermol/500-lotion/for/mature-skin
- France: https://lovi.care/skincare/fr/p/dermol/500-lotion/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/dermol/500-lotion/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/dermol/500-lotion/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/dermol/500-lotion/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/dermol/500-lotion/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/dermol/500-lotion/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/dermol/500-lotion/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/dermol/500-lotion/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/dermol/500-lotion/for/mature-skin