Dermalogica Daily Milkfoliant for acne-prone skin

How to apply

Questions and answers

What the research says

• A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face.

  Giornale Italiano Di Dermatologia E Venereologia, 2015

• Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris.

  Journal of Cosmetic Dermatology, 2021

• A novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid showed similar tolerance and efficacy compared with clindamycin 1% and benzoyl peroxide 5% gel in subjects with acne vulgaris.

  Journal of Drugs in Dermatology, 2013

• A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.

  Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

• A multiple W/O/W emulsion containing Rosmarinus officinalis L., Avena sativa L., and Linum usitatissimum L. extracts showed no irritant, phototoxic, inflammatory, or allergenic potential in human skin models and patch tests, establishing its safety as a cosmetic base.

  Pharmaceutics, 2021

• A repair cream containing Rhealba oat plantlets extract, l-ALA-l-GLU dipeptide, and hyaluronic acid provided immediate relief and was judged by doctors as good or very good in 96.8% of cases for wound healing in 2,363 patients following dermatological acts.

  Clinical, Cosmetic and Investigational Dermatology, 2018

• Topically applied Avena sativa and Avena Rhealba oatmeal extracts significantly reduced skin irritation parameters including a* parameter increase and blood flow increase compared to vehicle in 12 healthy individuals subjected to the sodium lauryl sulfate irritation model.

  Skin Pharmacology and Applied Skin Physiology, 2002

• Colloidal oat extracts diminished pro-inflammatory cytokines in vitro and colloidal oat lotion improved skin dryness, scaling, roughness, and itch intensity in healthy female subjects compared to baseline.

  Journal of Drugs in Dermatology, 2015

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo.

  Wilderness & Environmental Medicine, 2016

• Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation.

  Molecules, 2020

• Carica papaya leaf extracts obtained via supercritical fluid and conventional methods demonstrated antioxidant and cytoprotective effects on skin fibroblasts against oxidative stress, driven by their respective lipophilic and hydrophilic constituents.

  Molecules, 2021

• Sodium cocoyl isethionate micelles are too large to penetrate stratum corneum aqueous pores, resulting in significant steric hindrance that prevents skin barrier perturbation and explains its skin mildness.

  Journal of Cosmetic Science, 2007

• Camellia oleifera Abel shell 1,3-butanediol extract decreased facial melanin levels by 59% from baseline at 6 weeks compared to a placebo group showing no effect in 30 female subjects.

  Journal of Cosmetic Dermatology, 2019

• Camellia japonica oil activated the human COL1A2 promoter, induced type I procollagen synthesis, inhibited matrix metalloproteinase-1 activity, and reduced trans-epidermal water loss without inducing adverse reactions in human skin.

  Journal of Ethnopharmacology, 2007

• Camellia japonica placenta extract treatment upregulated hair growth marker genes in human follicle dermal papilla cells in vitro and improved scalp moisture, sebum, keratin, and erythema in 42 adult female participants in vivo.

  FEBS Open Bio, 2021

Ingredients

Sodium Cocoyl Isethionate, Microcrystalline Cellulose, Sodium Bicarbonate, Sorbitol, Zea Mays Starch, Sodium Cocoyl Glutamate, Saccharomyces Ferment, Rice Starch, Magnesium Oxide, Citric Acid, Tapioca Starch, Avena Sativa Kernel Protein Oat Kernel Protein, Camellia Oleifera Seed Extract, Silica, Coconut Fruit Extract, Inulin, Cassia Hydroxypropyltrimonium Chloride, Silybum Marianum Seed Oil, Kaolin, Lauryl Methacrylate Glycol Dimethacrylate Crosspolymer, Papain, Sodium Hyaluronate, Avena Sativa Kernel Extract Oat Kernel Extract, Helianthus Annuus Seed Oil Sunflower Seed Oil, Avena Sativa Bran Extract Oat Bran Extract, Glycine Soja Oil Soybean Oil, Citrus Aurantium Dulcis Peel Extract, Vitis Vinifera Fruit Extract Grape Fruit Extract, Bergamot Oil Fruit, Rosewood Oil Wood, Salvia Sclarea Oil, Eucalyptus Globulus Oil Leaf, Chamomilla Recutita Oil Flower Matricaria Oil Flower, Pumpkin Fruit Extract, Cucumis Sativus Fruit Extract, Perilla Ocymoides Leaf Extract, Daucus Carota Sativa Root Extract Carrot Root Extract, Sea Salt, Juniperus Virginiana Oil, Alpha-Glucan Oligosaccharide, Tocopherol, Castoryl Maleate, Caprylyl Glycol, Allantoin, Diglycerin, Maltodextrin, Lauroyl Lysine, Arginine, Saccharide Isomerate, Sodium Lauroyl Glutamate, Beta-Carotene, Xanthan Gum, Ethylhexylglycerin, 1,2-Hexanediol, Hydroxypropyl Methylcellulose, Dextrin, Sodium Palmitate, Sodium Chloride, Acacia Senegal Gum, Sodium Citrate, Water, O-Cymen-5-Ol, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.