# Derma E Anti-Wrinkle Cleanser for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/derma-e/anti-wrinkle-cleanser/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Derma E](https://lovi.care/skincare/brands/derma-e)
Category: [Cleansers](https://lovi.care/skincare/best/cleansers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other cleansers fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as glycolic acid and bakuchiol provide mild exfoliation and antioxidant activity, but it lacks sufficient hydrating ingredients for drier areas.
- The cleansing agents, Sodium Methyl Cocoyl Taurate and Cocamidopropyl Hydroxysultaine, are effective for cleansing your oily shine, but the formula does not contain targeted ingredients for oil control.
- The safety profile is good, with no risks of irritation for your combination skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/derma-e/anti-wrinkle-cleanser/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/derma-e/anti-wrinkle-cleanser/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/derma-e/anti-wrinkle-cleanser/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/p/derma-e/anti-wrinkle-cleanser/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/derma-e/anti-wrinkle-cleanser/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/derma-e/anti-wrinkle-cleanser/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/derma-e/anti-wrinkle-cleanser/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/derma-e/anti-wrinkle-cleanser/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/derma-e/anti-wrinkle-cleanser/for/oily-acne-prone-skin): Average

## Key ingredients

Vitamin A, Glycolic Acid, Bakuchiol, Retinol, Carica Papaya Fruit Extract

## What the research says

- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25914553/))
- Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days. ([Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo. ([Wilderness & Environmental Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/26827260/))
- A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face. ([Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/))
- Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation. ([Molecules, 2020](https://pubmed.ncbi.nlm.nih.gov/31991676/))

## Why other cleansers fit combination skin better

- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))

## What reviewers say

This cleanser is widely praised for its effective makeup removal and ability to leave skin feeling clean and smooth without excessive dryness. While it is a favorite for many seeking a budget-friendly, cruelty-free option for daily use, individuals with sensitive skin or specific skin conditions should be mindful of its exfoliating ingredients, which can occasionally lead to redness or irritation. This summary is based on a very large amount of data and should definitely be taken into account.

- Liked: Effective makeup removal (mostly mentioned)
- Liked: Gentle daily use (often mentioned)
- Liked: Non-stripping formula (often mentioned)
- Liked: Good value (sometimes noted)
- Disliked: Potential irritation (sometimes noted)
- Disliked: Ineffective for some (rarely noted)
- Disliked: Scent concerns (rarely noted)

## How to apply

- Use this cleanser AM and PM as part of your daily routine. Start 3×/week and build up to daily use if your skin tolerates it well.
- Apply this cleanser as the very first step in your morning routine and right after your pre-cleanser in the evening.
- Gently massage a small amount of cleanser onto your skin using circular motions. Rinse thoroughly with lukewarm water.
- For the best results , apply the cleanser directly onto slightly damp skin to help lift away excess oil.
- Avoid the immediate eye area and do a patch test before your first use to check for any sensitivity.
- Video: https://storage.pora.ai/6a08416bd9315041c09c72f61cf27cc1.mp4

## Questions and answers

### How well does Derma E Anti-Wrinkle Cleanser work for combination skin?

Derma E Anti-Wrinkle Cleanser offers a moderate fit for combination skin, helping clear oily shine while providing mild exfoliation, but it does not include enough hydrating ingredients for drier areas. A cleanser for this skin needs to balance oil production and maintain moisture with hydrating and barrier-repairing ingredients.

### Which ingredients make this cleanser a good fit for combination skin?

Glycolic acid and bakuchiol make this cleanser a good fit because they provide mild exfoliation and antioxidant activity for your skin. To work best for combination skin, a cleanser of this type needs soothing and hydrating ingredients to maintain moisture in drier areas while balancing oil production.

### What does Vitamin A do for combination skin?

Vitamin A helps clear breakouts and smooth out rough patches on combination skin, but it may cause dryness or irritation at first. To work well for this skin type, a product of this type needs soothing ingredients and lightweight moisture to keep the skin calm and comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32210603/), [Drugs & Aging, 1995](https://pubmed.ncbi.nlm.nih.gov/7663068/)

### What does Glycolic Acid do for combination skin?

Glycolic acid helps smooth and brighten combination skin by gently loosening dead surface cells to speed up skin renewal. This ingredient is unlikely to cause irritation when used properly, but it needs a reliable sunscreen during the day since it makes skin more sensitive to the sun.
Sources: [Acta Dermato-venereologica, 1995](https://pubmed.ncbi.nlm.nih.gov/8651024/), [Archives of Dermatological Research, 1997](https://pubmed.ncbi.nlm.nih.gov/9248619/)

### Where does this cleanser go in a skincare routine for combination skin?

This cleanser goes in both your morning and evening routine. It works for your combination skin, but to truly satisfy both your oily and dry zones, this type of cleanser needs extra hydrating ingredients for dry areas and targeted ingredients for oil control.

### Can I use this cleanser with vitamin C, and in what order?

You can use this cleanser with vitamin C by applying your vitamin C serum after washing and before your moisturizer. Since this formula contains glycolic acid and retinol, using them together may occasionally cause dryness or sensitivity, so you might want to alternate days or use vitamin C in the morning and this cleanser at night.

### How often should I use this cleanser?

You can use this cleanser daily in the morning and evening as part of your routine. It is unlikely to irritate your skin because it lacks harsh ingredients, though a product of this type needs more hydrating ingredients and oil-control agents to truly balance combination skin.

### Can this cleanser clog pores, cause breakouts or purging for combination skin?

This cleanser is unlikely to clog pores or cause breakouts on combination skin since it has a good safety profile with no harsh ingredients. However, because it contains glycolic acid and retinol, it may cause mild purging if your skin is not used to exfoliating ingredients. A product for this skin type needs extra hydrating ingredients to balance dry areas alongside oil-controlling ingredients for oily zones.

### Can I use this cleanser around the eyes or on my body?

You can use this cleanser on your body and around your eyes, as it has a good safety profile with no harsh ingredients that may cause irritation to thin skin. However, combination skin needs a cleanser that provides extra hydration for drier areas and targeted ingredients to help control oily shine.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cleanser fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/combination-skin) — Superior fit — $15.97 at Amazon
- [SOME BY MI Snail Truecica Miracle Repair Low pH Gel Cleanser](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-low-ph-gel-cleanser/for/combination-skin) — Superior fit — $13.40 at Amazon
- [Eminence Organic Skin Care Clear Skin Probiotic Cleanser](https://lovi.care/skincare/p/eminence-organic-skin-care/clear-skin-probiotic-cleanser/for/combination-skin) — Superior fit — $34.00 at Amazon

## Pairs well with

- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — $18.99 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — $14.97 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Sodium Methyl Cocoyl Taurate, Cocamidopropyl Hydroxysultaine, Cocamidopropyl Betaine, Glyceryl Laurate, Glycolic Acid, Bakuchiol, Retinyl Palmitate Vitamin A, Carica Papaya Fruit Extract, Equisetum Arvense Extract, Macrocystis Pyrifera Extract Kelp Extract, Potassium Sorbate, Phenoxyethanol, Ethylhexylglycerin, Oils
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/derma-e/anti-wrinkle-cleanser/for/combination-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/derma-e/anti-wrinkle-cleanser/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/derma-e/anti-wrinkle-cleanser/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/derma-e/anti-wrinkle-cleanser/for/combination-skin
- France: https://lovi.care/skincare/fr/p/derma-e/anti-wrinkle-cleanser/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/derma-e/anti-wrinkle-cleanser/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/derma-e/anti-wrinkle-cleanser/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-cleanser/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/derma-e/anti-wrinkle-cleanser/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/derma-e/anti-wrinkle-cleanser/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/derma-e/anti-wrinkle-cleanser/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/derma-e/anti-wrinkle-cleanser/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/derma-e/anti-wrinkle-cleanser/for/combination-skin