# COSRX The 6 Peptide Skin Booster Serum for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/p/cosrx/the-6-peptide-skin-booster-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [COSRX](https://lovi.care/skincare/brands/cosrx)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your oily skin, this serum effectively addresses acne and breakouts with niacinamide for oil control and inflammation reduction, complemented by acetyl hexapeptide-8 to hydrate and minimize fine lines.
- The inclusion of multiple peptides like copper tripeptide-1 and sh-polypeptide-121 further supports skin health and anti-aging benefits, enhancing overall skin appearance.
- The product boasts an excellent safety profile, with soothing ingredients like tocopherol and allantoin ensuring no irritation for your oily skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/cosrx/the-6-peptide-skin-booster-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/cosrx/the-6-peptide-skin-booster-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/cosrx/the-6-peptide-skin-booster-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/cosrx/the-6-peptide-skin-booster-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/cosrx/the-6-peptide-skin-booster-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/cosrx/the-6-peptide-skin-booster-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/cosrx/the-6-peptide-skin-booster-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/p/cosrx/the-6-peptide-skin-booster-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/p/cosrx/the-6-peptide-skin-booster-serum/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Sodium Hyaluronate, Peptides, N-Acetyl Glucosamine, Niacinamide, Allantoin

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))

## What reviewers say

Based on a very large amount of data, users consistently praise this serum as a lightweight, water-like "booster" that significantly improves skin texture and hydration without heaviness. It is widely celebrated for smoothing pores and creating a "glass skin" glow. A small minority of users with specific sensitivities experienced breakouts or closed comedones.

- Liked: Lightweight & fast-absorbing (mostly mentioned)
- Liked: Hydrating & plumping (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Gentle & non-irritating (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Ingredient sensitivities (rarely noted)
- Disliked: No visible results (rarely noted)
- Disliked: Sticky residue (rarely noted)

## How to apply

- Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
- Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
- Gently press a small amount into your skin and avoid rubbing to keep pores clear.
- Apply on clean, slightly damp skin to help the product absorb better and control oil.
- Avoid the sensitive eye area and do a simple patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes COSRX The 6 Peptide Skin Booster Serum a great fit for oily acne-prone skin?

This serum is a great fit because niacinamide helps control oil and calm breakouts, while multiple peptides hydrate and smooth fine lines. Soothing ingredients like allantoin ensure it is very unlikely to cause irritation on oily skin.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

This serum is a great fit for your oily acne-prone skin because it contains niacinamide to control oil and calm redness, along with acetyl hexapeptide-8 and copper tripeptide-1 to smooth and support skin health. Soothing ingredients like allantoin and tocopherol help ensure it stays gentle and is unlikely to cause irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Hyaluronic Acid do for oily acne-prone skin?

Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28163068/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35796638/)

### What do Peptides do for oily acne-prone skin?

Peptides help calm oily, acne-prone skin by targeting acne-causing bacteria and reducing redness and swelling. Advanced delivery methods like nanomicelles may also improve how deeply these helpful ingredients sink into the skin.
Sources: [Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/), [Bioorganic Chemistry, 2025](https://pubmed.ncbi.nlm.nih.gov/40925226/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This serum goes in the evening routine after cleansing and before moisturizing, as treatments with actives are placed in the evening for simplicity and extra safety. Soothing ingredients like allantoin and tocopherol help ensure this product is unlikely to cause irritation.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to hydrate and soothe your skin before your retinol product. This layered approach helps manage oil and reduce breakouts while keeping your skin calm and comfortable.

### How often should I use this serum?

This serum is a great fit for your oily acne-prone skin and is designed to be used in the evening routine. Applying it daily helps manage oil, soothe breakouts, and hydrate without causing irritation.

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is a great fit for your oily acne-prone skin and is unlikely to cause breakouts or clog pores, as it uses niacinamide to help control oil and soothe inflammation. Reviewers rarely report breakouts, and calming ingredients like allantoin help prevent irritation.

### Can I use this serum around the eyes or on my body?

This moisturizing treatment is generally safe to use on the body and around the eyes, though the skin around the eyes is much thinner and more delicate than body skin. Soothing ingredients like allantoin and tocopherol help ensure a low risk of irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/oily-acne-prone-skin) — Superior fit — $30.00 at Amazon
- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/oily-acne-prone-skin) — Superior fit — $8.40 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/oily-acne-prone-skin) — Superior fit — $22.25 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — $25.60 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-acne-prone-skin) — Superior fit — $25.99 at Amazon

## Where to buy

- Amazon.com: $17.50 (https://www.amazon.com/dp/B0CCJ3SRB9?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, Pentylene Glycol, 1,2-Hexanediol, Niacinamide, Ammonium Acryloyldimethyltaurate Vp Copolymer, Polyacrylate Crosspolymer-6, Butylene Glycol, Xanthan Gum, Ethylhexylglycerin, Adenosine, Polyquaternium-51, Disodium Edta, Citric Acid, Caprylyl Glycol, Betaine, T-Butyl Alcohol, Sodium Pca, Sodium Lactate, Acetyl Hexapeptide-8, Copper Tripeptide-1, Pca, Sh-Polypeptide-121, Serine, Alanine, Allantoin, Sodium Hyaluronate, Acetyl Glucosamine, Glycine, Glutamic Acid, Lysine Hcl, Threonine, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Arginine, Tocopherol, Oligopeptide-68, Proline, Dextran, Palmitoyl Tripeptide-8, Glycine Soja Oil Soybean Oil, Hydrogenated Lecithin, Potassium Sorbate, Sodium Oleate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/cosrx/the-6-peptide-skin-booster-serum/for/oily-acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/cosrx/the-6-peptide-skin-booster-serum/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/cosrx/the-6-peptide-skin-booster-serum/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/cosrx/the-6-peptide-skin-booster-serum/for/oily-acne-prone-skin
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