# Clinique Dramatically Different Moisturizing Lotion+ for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Clinique](https://lovi.care/skincare/brands/clinique)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other moisturizers fit it better.

## Why this fit

- Offers excellent moisturizing for your normal skin due to glycerin and sodium hyaluronate, which hydrate and plump effectively, though these ingredients are not specialized for targeting wrinkles and fine lines.
- Urea provides mild exfoliation and hydration, supporting general skin health without specifically addressing your primary concerns.
- The product is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/clinique/dramatically-different-moisturizing-lotion/for/oily-skin): Caution
- [Dry skin](https://lovi.care/skincare/p/clinique/dramatically-different-moisturizing-lotion/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/clinique/dramatically-different-moisturizing-lotion/for/combination-skin): Caution
- [Sensitive skin](https://lovi.care/skincare/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin): Low
- [Skin with dark spots](https://lovi.care/skincare/p/clinique/dramatically-different-moisturizing-lotion/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/clinique/dramatically-different-moisturizing-lotion/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/clinique/dramatically-different-moisturizing-lotion/for/oily-acne-prone-skin): Caution

## Key ingredients

Glycerin, Sodium Hyaluronate, Sesamum Indicum Oil, Cucumis Sativus Fruit Extract, Hordeum Vulgare Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Sesame-derived cosmetic ingredients are safe and not skin irritants, sensitizers, teratogens, or carcinogens at exposures resulting from cosmetic use. ([International Journal of Toxicology, 2011](https://pubmed.ncbi.nlm.nih.gov/21772026/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of sesame oil combined with standard care significantly reduced infusion-related phlebitis in adults compared to a control condition, with a risk ratio of 0.54. ([Complementary Therapies in Medicine, 2025](https://pubmed.ncbi.nlm.nih.gov/39743002/))
- Sesamol loaded silver nanoparticles gel showed a twofold increase in skin permeation and higher antioxidant activity compared to conventional formulations, demonstrating potential for topical wound healing delivery. ([Current Pharmaceutical Design, 2024](https://pubmed.ncbi.nlm.nih.gov/39192646/))
- Treatment with moderately ozonated sesame oil accelerates cutaneous wound closure and enhances cell response, angiogenesis, and VEGF and cyclin D1 expression in SKH1 mice compared to oil with lower or higher peroxide values and controls. ([Wound Repair and Regeneration, 2011](https://pubmed.ncbi.nlm.nih.gov/21134039/))
- Transgenic cucumber expressing poly-γ-glutamic acid synthesis genes increased water content by 6-14%, reduced water loss by 11-12%, decreased facial wrinkles and roughness by 19.58% and 24.97%, decreased skin melanin by 5.27%, and improved facial elasticity in human skin and zebrafish compared to controls. ([International Journal of Biological Macromolecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38336313/))
- Copper Oxide nanoparticles synthesized using cucumber extract exhibited antibacterial, antifungal, UV protection, and reactive-oxygen species inhibition properties with low cellular toxicity and skin-rejuvenating effects when incorporated into skin cream. ([Endocrine, Metabolic & Immune Disorders Drug Targets, 2021](https://pubmed.ncbi.nlm.nih.gov/32628604/))
- Topical treatment with Holothuria parva extract gel showed significant wound contraction compared to the negative control in full-thickness wounded rats. ([The International Journal of Lower Extremity Wounds, 2024](https://pubmed.ncbi.nlm.nih.gov/34791922/))

## Why other moisturizers fit mature skin better

- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))
- Nanoemulsions containing Macadamia integrifolia seed oil successfully enhanced skin hydration and reduced wrinkles in human volunteers, outperforming conventional emulsions in skin hydration enhancement. ([Nanomaterials, 2024](https://pubmed.ncbi.nlm.nih.gov/38668218/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))

## What reviewers say

Based on a very large amount of data, this lotion is a highly regarded staple for dry and combination skin, frequently praised for restoring the moisture barrier and leaving a soft, non-greasy finish. Most users report improved hydration and a healthy glow. A moderate number of users experienced breakouts or found the texture too heavy for oily areas.

- Liked: Effective hydration (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Gentle/fragrance-free (sometimes noted)
- Liked: Makeup compatibility (sometimes noted)
- Disliked: Caused breakouts (sometimes noted)
- Disliked: Formula change (rarely noted)
- Disliked: Greasy residue (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Clinique Dramatically Different Moisturizing Lotion+ work for mature skin?

This moisturizer works well for everyday hydration on mature skin, though other products fit this skin type better. To truly fit mature skin, a product needs potent ingredients that actively target wrinkles and fine lines while providing rich nourishing and soothing benefits.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for mature skin?

Glycerin, sodium hyaluronate, and urea make this cream a good fit for mature skin by helping to hydrate and keep the skin feeling soft. However, a moisturizer for mature skin also needs potent ingredients like peptides, antioxidants, and soothing components to target wrinkles and fine lines.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this cream go in a skincare routine for mature skin?

In a routine for mature skin, apply this moisturizer in the morning after your hydrating toner and before your sunscreen, and at night as the final step after your treatment. Because it fits mature skin only on an average level without targeting wrinkles and fine lines, this skin also needs ingredients like specialized anti-aging peptides or antioxidants to get the best results.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol by applying it after your retinol treatment to help keep your skin soft and reduce potential dryness. This type of routine is well tolerated, though mature skin often benefits most from a product that also specifically targets wrinkles and fine lines.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing lotion twice a day, morning and evening, to keep your skin hydrated. Regular daily application supports overall skin moisture and comfort with very little chance of irritation.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream may cause breakouts for mature skin, as some reviewers note. However, it is unlikely to cause irritation and leaves skin soft and smooth with ingredients like glycerin and sodium hyaluronate. Mature skin often needs specialized ingredients like retinol, peptides, or antioxidants to target fine lines and firmness more effectively.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Toxicology, 2011](https://pubmed.ncbi.nlm.nih.gov/21772026/)

### Can I use this cream around the eyes or on my body?

You can safely use this cream around your eyes and on your body because it is gentle and well tolerated, though the skin around the eyes is much thinner than on the body. A product of this type needs targeted ingredients like specialized anti-aging compounds and rich hydrators to effectively smooth fine lines and care for delicate areas.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon
- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/mature-skin) — Superior fit — $22.00 at Amazon
- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — $120.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — $46.00 at Amazon

## Where to buy

- Amazon.com: $36.75 (https://www.amazon.com/dp/B00JGLEQAO?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Mineral Oil, Paraffinum Liquidum, Huile Minérale, Glycerin, Petrolatum, Stearic Acid, Glyceryl Stearate, Sesamum Indicum Oil, Urea, Lanolin Alcohol, Triethanolamine, Hordeum Vulgare Extract, Extrait Dorge, Cucumis Sativus Fruit Extract, Helianthus Annuus Seedcake Sunflower Seedcake, Propylene Glycol Dicaprate, Sodium Hyaluronate, Butylene Glycol, Pentylene Glycol, Trisodium Edta, Phenoxyethanol, Ci 15985, Yellow 5 Ci 19140, Red 33 Ci 17200
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin
- France: https://lovi.care/skincare/fr/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin