# Cetaphil Healthy Radiance Antioxidant-C Serum for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Cetaphil](https://lovi.care/skincare/brands/cetaphil)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few serums fit it even better.

## Why this fit

- This serum offers high suitability for your normal skin, as sodium ascorbyl phosphate and niacinamide work effectively to brighten and even skin tone while also soothing redness and inflammation.
- The inclusion of glycerin and peppermint leaf extract further supports hydration and provides a calming sensation, making it a beneficial choice for managing irritation.
- The product is safe for your sensitive skin, containing no harsh ingredients and featuring soothing components like niacinamide and glycerin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/oily-acne-prone-skin): Superior

## Key ingredients

Niacinamide, Sodium Ascorbyl Phosphate Ascorbic Acid, Gentlebright Complex, Glycerin, Malva Sylvestris Flower Extract

## What the research says

- Niacinamide treatment mitigated environmental stress-induced inflammatory mediators and restored Lamin B1 levels in human epidermal keratinocytes, and reduced erythema and inflammatory biomarkers in a UV challenge clinical study of 40 female panelists compared to vehicle control. ([International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32657437/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Cooling skin temperature or applying topical menthol reduced histamine-induced itch intensity and flare diameters in healthy male volunteers. ([Neuroscience Letters, 1995](https://pubmed.ncbi.nlm.nih.gov/7624016/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Lectins and niacinamide reversibly inhibit melanosome transfer to keratinocytes without affecting cell viability, and topical niacinamide reduces facial hyperpigmented spots in a dose-dependent and reversible manner. ([Experimental Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/15946237/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of Malva sylvestris hydroalcoholic extract and its constituent malvidin 3-glucoside reduced ear oedema, polymorphonuclear cell influx, and interleukin-1beta levels in mice with 12-O-tetradecanoylphorbol-acetate-induced ear inflammation. ([Food and Chemical Toxicology, 2013](https://pubmed.ncbi.nlm.nih.gov/23684757/))
- Topical application of hydroalcoholic extract of Malva sylvestris reduced oedema, leukocyte migration, and keratinocyte hyperproliferation in a mouse ear model of chronic skin inflammation induced by multiple applications of TPA, and caused low toxicity and reduced cell proliferation by apoptosis in HaCaT keratinocytes. ([Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2017](https://pubmed.ncbi.nlm.nih.gov/28711022/))
- Topical administration of Malva sylvestris 1% aqueous extract improved cutaneous wound healing with less fibrosis, less scar formation, and less hair follicle damage compared to control groups in male BALB/c mice. ([Iranian Journal of Basic Medical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/26221487/))

## What reviewers say

This serum is highly regarded for its gentle formulation, effectively addressing dullness, hyperpigmentation, and post-acne marks, making it suitable for sensitive and acne-prone skin. Most users appreciate its quick absorption and the resulting brighter, more radiant complexion. Some users, however, have noted an unpleasant scent and occasional issues with product oxidation or a sticky feel.

- Liked: Gentle on skin (often mentioned)
- Liked: Absorbs quickly (sometimes noted)
- Liked: Fades dark spots (sometimes noted)
- Liked: Improves radiance (sometimes noted)
- Disliked: Unpleasant smell (sometimes noted)
- Disliked: Arrives oxidized (rarely noted)
- Disliked: Can feel sticky (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Cetaphil Antioxidant-C Serum a great fit for sensitive skin?

This serum is a great fit because ingredients like niacinamide and sodium ascorbyl phosphate brighten skin while soothing redness and calming irritation. Glycerin and peppermint leaf extract further help by keeping skin hydrated and comfortable.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32657437/), [Neuroscience Letters, 1995](https://pubmed.ncbi.nlm.nih.gov/7624016/)

### Which ingredients make this serum a good fit for sensitive skin?

This serum is a great fit because it contains niacinamide and glycerin, which soothe redness and keep sensitive skin calm and comfortable. These gentle ingredients work together to calm irritation without harsh components, making it very well suited for delicate skin.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32657437/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Sodium Ascorbyl Phosphate do for sensitive skin?

Sodium Ascorbyl Phosphate is generally well tolerated and helps calm and protect sensitive skin by reducing redness and fighting oxidation. This form of vitamin C is gentle and unlikely to cause irritation, making it a soothing choice for easily upset skin.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492184/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in your evening routine, as treatments with active ingredients are placed in the evening for simplicity and extra safety around sun exposure. Some of these serums can also be used in the morning or twice a day.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to brighten and calm the skin, followed by your retinol afterward. Using a soothing and hydrating routine helps keep sensitive skin comfortable while using active treatments like retinol.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

This serum is used in the evening routine, starting once a week and gradually increasing as your skin adjusts. Daily use of gentle antioxidants and soothing ingredients like niacinamide and glycerin helps brighten tone and calm irritation with a very low risk of side effects.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32657437/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is a great fit for sensitive skin and is unlikely to clog pores, cause breakouts, or lead to purging. Its formula features soothing ingredients like niacinamide and glycerin to help keep skin calm without heavy oils that block pores.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32657437/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — $53.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — $39.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — $25.08 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — $28.08 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — $28.05 at Amazon
- Moisturizer with Sun Protection: [innisfree Daily Mild Sunscreen](https://lovi.care/skincare/p/innisfree/daily-mild-sunscreen/for/sensitive-skin) — Superior fit — $18.00 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Sodium Ascorbyl Phosphate, Methyl Gluceth-20, Butylene Glycol, Bis-Peg-18 Methyl Ether Dimethyl Silane, Niacinamide, Glycerin, Citric Acid, Xanthan Gum, Phenoxyethanol, Sorbitan Oleate Decylglucoside Crosspolymer, Hydroxyacetophenone, Alcohol, Disodium Edta, Sodium Pca, Caprylyl Glycol, Malva Sylvestris Stem Extract Flower Leaf, Peppermint Leaf Extract, Primula Veris Flower Extract, Alchemilla Vulgaris Stem Extract Flower Leaf, Veronica Officinalis Stem Extract Flower Leaf, Melissa Officinalis Leaf Extract, Achillea Millefolium Stem Extract Flower Leaf, Erythritol, Chondrus Crispus, Grapefruit Peel Extract, Citrus Aurantium Dulcis Peel Extract, Benzoic Acid, Sodium Hydroxide, Sorbic Acid, Lemon Peel Extract, Bht
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/sensitive-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/sensitive-skin
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