# Cetaphil Healthy Radiance Antioxidant-C Serum for acne-prone skin

**Lovi Fit: Superior fit for acne-prone skin.**
Combination Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Cetaphil](https://lovi.care/skincare/brands/cetaphil)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for acne-prone skin.

## Why this fit

- Excellent suitability for your combination skin and acne, blemishes, and breakouts is provided by Sodium Ascorbyl Phosphate and Niacinamide, which effectively target inflammation and regulate oil production.
- The inclusion of Glycerin and multiple botanical extracts ensures hydration and soothes the skin, complementing the primary active ingredients.
- This formula is safe for your skin, containing no harsh ingredients and featuring beneficial components like Niacinamide and Glycerin to prevent irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/acne-prone-skin): Superior (this page)
- [Skin with dark spots](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/oily-acne-prone-skin): Superior

## Key ingredients

Niacinamide, Sodium Ascorbyl Phosphate Ascorbic Acid, Gentlebright Complex, Glycerin, Malva Sylvestris Flower Extract

## What the research says

- Topical combination of 5% sodium ascorbyl phosphate and 0.2% retinol reduced inflammatory acne lesions by 29.28% at 4 weeks and 63.10% at 8 weeks, outperforming either agent alone. ([International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19134126/))
- Combined ascorbyl palmitate and sodium ascorbyl phosphate treatment significantly reduced facial sebum secretions in healthy female volunteers compared to a placebo control over 90 days. ([Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/))
- Niacinamide treatment mitigated environmental stress-induced inflammatory mediators and restored Lamin B1 levels in human epidermal keratinocytes, and reduced erythema and inflammatory biomarkers in a UV challenge clinical study of 40 female panelists compared to vehicle control. ([International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32657437/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Lectins and niacinamide reversibly inhibit melanosome transfer to keratinocytes without affecting cell viability, and topical niacinamide reduces facial hyperpigmented spots in a dose-dependent and reversible manner. ([Experimental Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/15946237/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of Malva sylvestris hydroalcoholic extract and its constituent malvidin 3-glucoside reduced ear oedema, polymorphonuclear cell influx, and interleukin-1beta levels in mice with 12-O-tetradecanoylphorbol-acetate-induced ear inflammation. ([Food and Chemical Toxicology, 2013](https://pubmed.ncbi.nlm.nih.gov/23684757/))
- Topical application of hydroalcoholic extract of Malva sylvestris reduced oedema, leukocyte migration, and keratinocyte hyperproliferation in a mouse ear model of chronic skin inflammation induced by multiple applications of TPA, and caused low toxicity and reduced cell proliferation by apoptosis in HaCaT keratinocytes. ([Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2017](https://pubmed.ncbi.nlm.nih.gov/28711022/))
- Topical administration of Malva sylvestris 1% aqueous extract improved cutaneous wound healing with less fibrosis, less scar formation, and less hair follicle damage compared to control groups in male BALB/c mice. ([Iranian Journal of Basic Medical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/26221487/))

## What reviewers say

This serum is highly regarded for its gentle formulation, effectively addressing dullness, hyperpigmentation, and post-acne marks, making it suitable for sensitive and acne-prone skin. Most users appreciate its quick absorption and the resulting brighter, more radiant complexion. Some users, however, have noted an unpleasant scent and occasional issues with product oxidation or a sticky feel.

- Liked: Gentle on skin (often mentioned)
- Liked: Absorbs quickly (sometimes noted)
- Liked: Fades dark spots (sometimes noted)
- Liked: Improves radiance (sometimes noted)
- Disliked: Unpleasant smell (sometimes noted)
- Disliked: Arrives oxidized (rarely noted)
- Disliked: Can feel sticky (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Cetaphil Antioxidant-C Serum one of the best fits for acne-prone skin?

This serum is one of the best fits for acne-prone skin because ingredients like sodium ascorbyl phosphate and niacinamide effectively calm inflammation and balance oil production. It also includes glycerin and botanical extracts to keep skin hydrated while helping prevent irritation.
Sources: [International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19134126/), [Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/)

### Which ingredients make this serum a good fit for acne-prone skin?

Sodium ascorbyl phosphate and niacinamide make this serum a great fit for acne-prone skin because they help calm swelling and keep oil in check. Glycerin and botanical extracts add soothing moisture, while the gentle formula is unlikely to cause irritation.
Sources: [Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/), [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32657437/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### What does Sodium Ascorbyl Phosphate do for acne-prone skin?

Sodium Ascorbyl Phosphate helps acne-prone skin by providing effective antimicrobial action and preventing sebum oxidation. It may significantly improve acne lesions and keep skin clear when used regularly.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492184/), [Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20367669/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment serum goes in your evening routine, applied after cleansing and toning and before moisturizing. Putting treatments in the evening provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first in your routine and following it with your retinol. Using these ingredients together is unlikely to cause irritation because the formula is gentle and designed to calm the skin.

### How often should I use this serum?

This serum fits your acne-prone skin exceptionally well and can be used in the evening as part of your routine. Ingredients like sodium ascorbyl phosphate and niacinamide help target inflammation and control oil with a safe, gentle profile.
Sources: [International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19134126/), [Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to clog pores or cause breakouts on acne-prone skin because it contains niacinamide and sodium ascorbyl phosphate, which help calm inflammation and control excess oil. It also features glycerin and botanical extracts to keep your skin hydrated and comfortable without causing irritation.
Sources: [International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19134126/), [Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — $28.88 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — $39.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — $15.60 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — $15.50 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Sodium Ascorbyl Phosphate, Methyl Gluceth-20, Butylene Glycol, Bis-Peg-18 Methyl Ether Dimethyl Silane, Niacinamide, Glycerin, Citric Acid, Xanthan Gum, Phenoxyethanol, Sorbitan Oleate Decylglucoside Crosspolymer, Hydroxyacetophenone, Alcohol, Disodium Edta, Sodium Pca, Caprylyl Glycol, Malva Sylvestris Stem Extract Flower Leaf, Peppermint Leaf Extract, Primula Veris Flower Extract, Alchemilla Vulgaris Stem Extract Flower Leaf, Veronica Officinalis Stem Extract Flower Leaf, Melissa Officinalis Leaf Extract, Achillea Millefolium Stem Extract Flower Leaf, Erythritol, Chondrus Crispus, Grapefruit Peel Extract, Citrus Aurantium Dulcis Peel Extract, Benzoic Acid, Sodium Hydroxide, Sorbic Acid, Lemon Peel Extract, Bht
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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