# Biotulin Supreme Skin Gel for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/biotulin/supreme-skin-gel/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Biotulin](https://lovi.care/skincare/brands/biotulin)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your dry skin due to Glycerin and Sodium Hyaluronate providing humectant action, but it lacks sufficient emollient ingredients for optimal hydration.
- The product provides general skincare benefits like hydration, which are mostly supportive for your dry or flaky skin.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/biotulin/supreme-skin-gel/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/biotulin/supreme-skin-gel/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/p/biotulin/supreme-skin-gel/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/biotulin/supreme-skin-gel/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/biotulin/supreme-skin-gel/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/biotulin/supreme-skin-gel/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/biotulin/supreme-skin-gel/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/biotulin/supreme-skin-gel/for/oily-acne-prone-skin): Average

## Key ingredients

Acmella Oleracea Extract, Imperata Cylindrica Root Extract, Sodium Hyaluronate, Vitis Vinifera Leaf Extract Grape Leaf Extract, Spilanthol

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- An Acmella oleracea extract-loaded glycolipid emulsion serum applied topically demonstrated safety with no ocular irritation or systemic dermal absorption, alongside significant improvements in facial skin hydration, smoothness, and reductions in roughness, scaliness, and wrinkles. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/))
- An all-natural anti-wrinkle emulsion serum containing Acmella oleracea extract demonstrated safe skin tolerability and reduced facial wrinkles in human volunteers after 2 weeks of application. ([International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/))
- A novel formulation containing supramolecular retinol plus acmella oleracea extract significantly reduced dark circles by 13.8% in melanin index, decreased fine wrinkles, and increased skin firmness by 13.0% in 33 Chinese urban women after 6 weeks of use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34806292/))
- The optimized squalane-based spilanthol emulsion achieved a maximum skin retention of 118.71 μg/g and restored skin hydroxyproline content to 23.99 μg/g, outperforming positive and negative groups due to high drug release and miscibility driven by weak Van der Waals interactions. ([AAPS PharmSciTech, 2019](https://pubmed.ncbi.nlm.nih.gov/31222590/))
- Treatment with methanolic extract of Acmella oleracea leaves exerted potent antioxidant, anti-inflammatory, antimicrobial, and wound healing effects in vitro by reducing inflammatory mediators, scavenging free radicals, inhibiting bacterial growth, and enhancing fibroblast migration without inducing cytotoxicity. ([Journal of Ethnopharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/39357584/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A combination of Vitis vinifera shoot extract and a biotechnological extract demonstrated significant in vitro and in vivo antioxidant effects and improved clinical signs of photoaged skin in female subjects after a 4-week application. ([Journal of Drugs in Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17691204/))
- Pre-treatment with Vitis vinifera L. water extract (100 ΓΙg/mL) demonstrated antioxidant and scavenger activity against UV-A radiation and exerted an anti-mutagenic effect by maintaining apoptosis in UV-A and UV-B irradiated human keratinocytes (HaCaT). ([Journal of Photochemistry and Photobiology. B, Biology, 2020](https://pubmed.ncbi.nlm.nih.gov/32028189/))
- A water extract from grapevine leaves inhibited proinflammatory-induced interleukin-8 and vascular endothelial growth factor secretion in human keratinocytes compared to untreated challenged cells. ([Antioxidants, 2019](https://pubmed.ncbi.nlm.nih.gov/31100904/))

## Why other serums fit dry skin better

- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Biotulin Supreme Skin Gel work for dry skin?

This gel works moderately well for dry skin, offering basic hydration through ingredients like glycerin and sodium hyaluronate. However, it lacks sufficient softening ingredients for optimal moisture levels. A product for dry skin needs rich, soothing ingredients, ceramides, niacinamide, peptides, or vitamin C to deeply nourish and repair the skin barrier.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this gel a good fit for dry skin?

This gel works moderately well for dry skin because glycerin and sodium hyaluronate draw in moisture. However, a product of this type needs rich softening ingredients, soothing plant extracts, ceramides, and vitamins to lock in hydration and deeply nourish dry skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Acmella Oleracea Extract do for dry skin?

Acmella oleracea extract helps improve dry skin by boosting hydration and smoothing out roughness and wrinkles. It is gentle and safe to use, making skin feel soft and comfortable after just a couple of weeks of daily application.
Sources: [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/), [International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/)

### What does Imperata Cylindrica Root Extract do for dry skin?

Imperata cylindrica root extract is unlikely to provide the hydration and moisture barrier support that dry skin needs. Dry skin of this type needs rich, soothing ingredients like ceramides, botanical oils, and glycerin to stay soft and smooth.

### Where does this gel go in a skincare routine for dry skin?

This treatment goes in your evening routine after cleansing and before your moisturizer. A product of this type needs rich moisturizing ingredients to properly soften and comfort dry skin.

### Can I use this gel with retinol, and in what order?

You can use this gel in the evening before your moisturizer, and it is unlikely to irritate your dry skin since it has no harsh ingredients. However, because your skin needs extra smoothing and softening oils alongside humectants like glycerin and sodium hyaluronate, you should pair it with a rich moisturizing cream to lock in deep hydration.

### How often should I use this gel?

You can use this treatment in your evening routine. A product of this type needs richer, softening ingredients to properly comfort dry skin.

### Can this gel clog pores, cause breakouts or purging for dry skin?

This gel is unlikely to cause breakouts or clog pores on dry skin, as its safety profile is excellent and it lacks harsh or irritating ingredients. It helps keep skin smooth and hydrated, though dry skin generally needs richer, softening ingredients to lock in moisture.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/)

### Is this gel fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — $16.75 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — $53.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — $19.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — $19.99 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — $16.99 at Amazon
- Moisturizer: [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/dry-skin) — Superior fit — $22.00 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Butylene Glycol, Alcohol, Imperata Cylindrica Root Extract, Acmella Oleracea Extract, Xanthan Gum, Chondrus Crispus, Benzoic Acid, Phenoxyethanol, Vitis Vinifera Leaf Extract Grape Leaf Extract, Sodium Hyaluronate, Sodium Hydroxide, Carbomer, Caprylyl Glycol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Ethylhexylglycerin, Dehydroacetic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biotulin/supreme-skin-gel/for/dry-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/biotulin/supreme-skin-gel/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/biotulin/supreme-skin-gel/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/biotulin/supreme-skin-gel/for/dry-skin
- France: https://lovi.care/skincare/fr/p/biotulin/supreme-skin-gel/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/biotulin/supreme-skin-gel/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/biotulin/supreme-skin-gel/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/biotulin/supreme-skin-gel/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/biotulin/supreme-skin-gel/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/biotulin/supreme-skin-gel/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/biotulin/supreme-skin-gel/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biotulin/supreme-skin-gel/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biotulin/supreme-skin-gel/for/dry-skin