# Biossance Squalane + Probiotic Gel Moisturizer for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Biossance](https://lovi.care/skincare/brands/biossance)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other moisturizers fit it better.

## Why this fit

- Offers moderate benefits for your normal skin, as squalane and glycerin provide excellent hydration and barrier support, though these ingredients do not directly address your primary concern of wrinkles and fine lines.
- The inclusion of allantoin and bisabolol offers soothing properties, which are beneficial for maintaining overall skin health.
- The product is safe for your normal skin, with no reported risks of irritation due to its gentle formulation and absence of harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/biossance/squalane-probiotic-gel-moisturizer/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/biossance/squalane-probiotic-gel-moisturizer/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/biossance/squalane-probiotic-gel-moisturizer/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/biossance/squalane-probiotic-gel-moisturizer/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/biossance/squalane-probiotic-gel-moisturizer/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/biossance/squalane-probiotic-gel-moisturizer/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/biossance/squalane-probiotic-gel-moisturizer/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/biossance/squalane-probiotic-gel-moisturizer/for/oily-acne-prone-skin): High

## Key ingredients

Squalane, Probiotics, Glycerin, Lactococcus Lysate Ferment, Zingiber Officinale Root Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- A 1-year clinical study on human facial skin demonstrated that Zingiber officinale (L.) Rose extract inhibits the UV-induced decrease in skin elasticity and prevents or improves wrinkle formation around the eye. ([Archives of Dermatological Research, 2008](https://pubmed.ncbi.nlm.nih.gov/17968573/))
- Ginger extract transethosomal hydrogel improved skin permeability, sustained drug release, and exhibited significant inhibition of edema swelling along with reduced reactive oxygen species and prostaglandin E2 compared to free ginger extract hydrogel and ketoprofen gel in a rat-paw edema model. ([International Journal of Nanomedicine, 2023](https://pubmed.ncbi.nlm.nih.gov/36945254/))
- Topical delivery of ginger extract-loaded nanoemulsions significantly reduced arthritic symptoms, paw edema inhibition by 27.7%, and inflammatory cytokines in RA-induced rats compared to the negative control. ([Journal of Pharmaceutical Sciences, 2023](https://pubmed.ncbi.nlm.nih.gov/36773928/))

## Why other moisturizers fit mature skin better

- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))
- Nanoemulsions containing Macadamia integrifolia seed oil successfully enhanced skin hydration and reduced wrinkles in human volunteers, outperforming conventional emulsions in skin hydration enhancement. ([Nanomaterials, 2024](https://pubmed.ncbi.nlm.nih.gov/38668218/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))

## What reviewers say

Based on a very large amount of data, this lightweight gel moisturizer is highly recommended for oily, combination, and sensitive skin types, effectively hydrating without pore clogging and visibly reducing redness. However, a significant number of recent reviews indicate dissatisfaction with a formula change, noting a stickier texture and less pleasant scent compared to the original. Dry skin types may find it insufficient for hydration, and some users express concerns about the price point. A small number of users have reported irritation or breakouts.

- Liked: Lightweight & fast absorbing (mostly mentioned)
- Liked: Balances oily skin (often mentioned)
- Liked: Calms redness & irritation (often mentioned)
- Disliked: Reformulation complaints (often mentioned)
- Liked: Excellent makeup base (sometimes noted)
- Disliked: Not hydrating enough (sometimes noted)
- Disliked: Price point (sometimes noted)
- Disliked: Irritation and breakouts (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Biossance Squalane + Probiotic Gel Moisturizer work for mature skin?

This moisturizer works reasonably well for mature skin by keeping it hydrated and calm, though it does not directly target wrinkles and fine lines. A product of this type needs to include potent ingredients for lines and wrinkles, peptides, and antioxidants to best fit mature skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this moisturizer a good fit for mature skin?

Squalane and glycerin make this moisturizer a good fit for mature skin by providing hydration and barrier support. To better address mature skin, a product of this type needs ingredients that target wrinkles and fine lines, along with peptides and antioxidants.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Squalane do for mature skin?

Squalane helps keep mature skin feeling soft and smooth by boosting moisture and protecting the skin barrier. It also provides antioxidant support that helps improve the look of fine lines and wrinkles over time.
Sources: [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/), [Journal of Nanoscience and Nanotechnology, 2010](https://pubmed.ncbi.nlm.nih.gov/21137794/)

### What do Probiotics do for mature skin?

Probiotics help mature skin by improving moisture, firmness, and elasticity while smoothing out wrinkles. Topical application of these ingredients supports the skin microbiome and may reduce signs of aging.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38174442/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36718014/)

### Where does it go in a skincare routine for mature skin?

This moisturizer goes in the morning and evening after your cleanser and toner, and before sunscreen in the day. It provides good hydration and soothing care, but mature skin also needs ingredients that directly target wrinkles and fine lines.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this moisturizer with retinol, and in what order?

You can use this moisturizer with retinol by applying the retinol first, letting it absorb, and then following with the moisturizer. This helps keep your skin soft and is unlikely to cause irritation because the formula is gentle. Mature skin also needs targeted ingredients like peptides or antioxidants to smooth fine lines and wrinkles.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use it?

You can use this moisturizing treatment twice a day as part of your morning and evening routine to keep your skin hydrated and supported. Regular daily application helps maintain moisture and keeps the skin soft, though mature skin also needs targeted anti-aging ingredients like peptides or retinoids to properly address fine lines and wrinkles.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can it clog pores, cause breakouts or purging for mature skin?

This moisturizer is unlikely to clog pores or cause breakouts for mature skin, as it has a gentle formula with low complaints of irritation and breakouts. To better target wrinkles and fine lines, mature skin needs products with ingredients like retinoids or peptides.

### Can I use this moisturizer around the eyes or on my body?

You can safely use this moisturizing treatment around your eyes and on your body, as its gentle formulation is unlikely to cause irritation. To properly address mature skin concerns like wrinkles and fine lines in these delicate areas, this type of product needs added firming ingredients like peptides, retinol, or specialized plant extracts.

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/mature-skin) — Superior fit — $22.00 at Amazon
- [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon
- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — $120.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — $46.00 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Squalane, Glycerin, Dimethicone, Pentylene Glycol, Ammonium Acryloyldimethyltaurate Vp Copolymer, Lactococcus Lysate Ferment, Caprylic Capric Triglyceride, Phenoxyethanol, Caprylyl Glycol, Dimethiconol, Chondrus Crispus Extract, Allantoin, Bisabolol, Glycine Soja Soybean Sterols, Linoleic Acid, Sodium Phytate, Lecithin, Sodium Hydroxide, Sodium Hyaluronate, Lactic Acid, Lepidium Sativum Extract Sprout, Sodium Chloride, Sodium Benzoate, Citric Acid, Zingiber Officinale Root Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin
- France: https://lovi.care/skincare/fr/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin