# Biossance Squalane + Phyto-Retinol Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Biossance](https://lovi.care/skincare/brands/biossance)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin, this serum effectively addresses wrinkles and fine lines with bakuchiol and niacinamide, promoting skin renewal and collagen production. Squalane and hyaluronic acid provide essential hydration and barrier support, maintaining your skin's balance.
- Rosa canina fruit oil offers additional antioxidant benefits, complementing the primary anti-aging ingredients.
- The formula is safe for your skin, featuring soothing ingredients and avoiding harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Squalane, Bakuchiol, Niacinamide, Sodium Hyaluronate, Biosaccharide Gum-1

## What the research says

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days. ([Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25914553/))
- Bakuchiol functions as an anti-aging compound through retinol-like regulation of gene expression, producing significant improvements in lines, wrinkles, pigmentation, elasticity, firmness, and photo-damage after 12 weeks of twice-a-day facial application without usual retinol therapy-associated undesirable effects. ([International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24471735/))
- A nature-based bakuchiol-containing cleanser and moisturizer improved visual and tactile smoothness, clarity, radiance, overall appearance, global anti-aging, and skin moisture content by 16% in 60 female subjects with sensitive mild to moderate photodamaged skin over 4 weeks. ([Journal of Drugs in Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33346506/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Users frequently report improvements in skin texture and significant hydration without the irritation commonly associated with retinoids. Some users find the name misleading and the scent polarizing, while others note the high price and recent availability issues.

- Liked: Gentle, non-irritating (mostly mentioned)
- Liked: Hydrating and moisturizing (often mentioned)
- Disliked: Availability issues (often mentioned)
- Liked: Improves skin texture (sometimes noted)
- Liked: Lightweight formula (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Misleading name (sometimes noted)
- Disliked: Polarizing scent (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Biossance Squalane + Phyto-Retinol Serum a great fit for mature skin?

This serum is a great fit because bakuchiol and niacinamide help smooth out fine lines and wrinkles while encouraging skin renewal. At the same time, squalane and hyaluronic acid keep your skin well hydrated and support its natural barrier. Rosa canina fruit oil provides extra antioxidant protection to help keep your skin looking healthy and balanced.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Which ingredients make this serum a good fit for mature skin?

Bakuchiol and niacinamide make this serum a great fit for mature skin because they help smooth wrinkles and fine lines by promoting skin renewal and collagen production. Squalane and hyaluronic acid add essential moisture and support the skin barrier, keeping your face soft and balanced.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### What does Squalane do for mature skin?

Squalane helps keep mature skin feeling soft and smooth by boosting moisture and protecting the skin barrier. It also provides antioxidant support that helps improve the look of fine lines and wrinkles over time.
Sources: [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/), [Journal of Nanoscience and Nanotechnology, 2010](https://pubmed.ncbi.nlm.nih.gov/21137794/)

### What does Bakuchiol do for mature skin?

Bakuchiol helps smooth fine lines, firm up mature skin, and even out dark spots when applied twice daily. It works much like retinol to improve elasticity and signs of aging, but is unlikely to cause the dryness and stinging often linked to traditional retinol products.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24471735/)

### Where does this serum go in a skincare routine for mature skin?

This treatment serum goes in your evening routine, applied after cleansing and toning and before your moisturizer. Putting treatments in the evening keeps things simple and adds extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol, but it is best to alternate them or apply retinol first and follow with this treatment to keep your skin calm and hydrated. Because this formula contains bakuchiol and niacinamide, it helps smooth fine lines while supporting your skin barrier, making it less likely to feel dry or irritated when paired with strong anti-aging products.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### How often should I use this serum?

You can use this serum in your evening routine, as treatments fit best there for simplicity and extra safety around sun exposure. If your skin tolerates it well, you may be able to use it more often.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it relies on lightweight, hydrating ingredients like squalane and hyaluronic acid rather than heavy oils. It also contains bakuchiol, which helps smooth fine lines without the irritation or purging typically caused by traditional retinol.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (linalool, geraniol, and limonene).

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — $53.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — $39.99 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — $810.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Squalane, Glycerin, Niacinamide, Sodium Acrylates Copolymer, Bakuchiol, Sodium Hyaluronate, Rosa Canina Oil Fruit, Citrus Aurantium Amara Peel Oil, Biosaccharide Gum-1, Lecithin, Hexylene Glycol, Ethylhexylglycerin, Caprylyl Glycol, Phenoxyethanol, Sodium Gluconate, Citric Acid, Linalool, Geraniol, Limonene, Yeast Extract, Amino Acids, Tetrasodium Glutamate Diacetate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-phyto-retinol-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-phyto-retinol-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-phyto-retinol-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/biossance/squalane-phyto-retinol-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-phyto-retinol-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-phyto-retinol-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-phyto-retinol-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-phyto-retinol-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-phyto-retinol-serum/for/mature-skin
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- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-phyto-retinol-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-phyto-retinol-serum/for/mature-skin