# Biossance Squalane + Phyto-Retinol Serum for dry sensitive skin

**Lovi Fit: High fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Biossance](https://lovi.care/skincare/brands/biossance)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry sensitive skin; a few serums fit it even better.

## Why this fit

- Excellent for your dry and sensitive skin as squalane and sodium hyaluronate provide essential hydration and support your skin barrier, while bakuchiol and niacinamide work to smooth texture and minimize fine lines.
- Rosa Canina Oil Fruit further nourishes and repairs, enhancing the emollient properties beneficial for dry or flaky skin.
- The formula is safe for your skin due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin): High (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Squalane, Bakuchiol, Niacinamide, Sodium Hyaluronate, Biosaccharide Gum-1

## What the research says

- Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days. ([Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Sunflower and rosehip oil nanoemulsions prepared with a mix of phospholipids and synthetic emulsifiers permeated intact skin to the dermis and showed a more prominent healing effect in a human organotypic skin explant culture wound model compared to nanoemulsions prepared only with phospholipids. ([Pharmaceutics, 2023](https://pubmed.ncbi.nlm.nih.gov/36986857/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25914553/))
- Bakuchiol functions as an anti-aging compound through retinol-like regulation of gene expression, producing significant improvements in lines, wrinkles, pigmentation, elasticity, firmness, and photo-damage after 12 weeks of twice-a-day facial application without usual retinol therapy-associated undesirable effects. ([International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24471735/))
- A nature-based bakuchiol-containing cleanser and moisturizer improved visual and tactile smoothness, clarity, radiance, overall appearance, global anti-aging, and skin moisture content by 16% in 60 female subjects with sensitive mild to moderate photodamaged skin over 4 weeks. ([Journal of Drugs in Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33346506/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Users frequently report improvements in skin texture and significant hydration without the irritation commonly associated with retinoids. Some users find the name misleading and the scent polarizing, while others note the high price and recent availability issues.

- Liked: Gentle, non-irritating (mostly mentioned)
- Liked: Hydrating and moisturizing (often mentioned)
- Disliked: Availability issues (often mentioned)
- Liked: Improves skin texture (sometimes noted)
- Liked: Lightweight formula (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Misleading name (sometimes noted)
- Disliked: Polarizing scent (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Biossance Squalane + Phyto-Retinol Serum a great fit for dry sensitive skin?

Biossance Squalane + Phyto-Retinol Serum is a great fit for dry sensitive skin because squalane and sodium hyaluronate deliver essential moisture to calm and comfort dry areas. At the same time, bakuchiol and niacinamide help smooth your skin texture and minimize fine lines without causing the irritation often linked to traditional retinol.
Sources: [Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/), [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Which ingredients make this serum a good fit for dry sensitive skin?

Squalane and sodium hyaluronate make this serum a great fit by providing essential hydration and supporting your skin barrier, while bakuchiol and niacinamide smooth texture without the stinging often caused by traditional retinol. Rosa Canina fruit oil further nourishes and repairs, making it especially beneficial for dry or flaky skin.
Sources: [Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/), [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Squalane do for dry sensitive skin?

Squalane helps keep dry sensitive skin soft and smooth by locking in moisture and calming irritation without causing flare-ups. It is unlikely to cause redness or discomfort, making it a gentle choice that supports the skin barrier. This type of skin needs ingredients that deeply hydrate and soothe, such as plant oils and antioxidants.
Sources: [International Journal of Molecular Sciences, 2017](https://pubmed.ncbi.nlm.nih.gov/29280987/), [Molecules, 2009](https://pubmed.ncbi.nlm.nih.gov/19169201/)

### What does Bakuchiol do for dry sensitive skin?

Bakuchiol is a gentle, plant-based option that helps smooth lines, improve firmness, and even out skin tone without causing the dryness, redness, or stinging often linked to traditional retinol. It is generally well-tolerated by delicate skin types and helps improve overall moisture and softness with regular use.
Sources: [Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/), [Journal of Drugs in Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33346506/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This serum goes in the evening routine after cleansing and toning, and before moisturizing. Putting it in the evening helps provide extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

This serum already contains bakuchiol, a plant-based alternative that helps smooth texture and minimize fine lines with a very gentle effect on sensitive skin. Using an additional retinol product at the same time is usually unnecessary and may trigger irritation or dryness.
Sources: [Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/), [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### How often should I use this serum?

You can use this serum in your evening routine. It helps smooth texture and calm dry sensitive skin without causing irritation.
Sources: [Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/), [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to clog pores or cause breakouts for dry sensitive skin because it relies on lightweight, hydrating ingredients like squalane and sodium hyaluronate rather than heavy oils. It does not contain traditional retinol, so it is also unlikely to cause skin purging, while bakuchiol and niacinamide help keep skin smooth and calm.
Sources: [Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/), [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (linalool, geraniol, and limonene).

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — $39.99 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin) — Superior fit — $53.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-sensitive-skin) — Superior fit — $16.75 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — $16.97 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — $28.05 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — $18.99 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Squalane, Glycerin, Niacinamide, Sodium Acrylates Copolymer, Bakuchiol, Sodium Hyaluronate, Rosa Canina Oil Fruit, Citrus Aurantium Amara Peel Oil, Biosaccharide Gum-1, Lecithin, Hexylene Glycol, Ethylhexylglycerin, Caprylyl Glycol, Phenoxyethanol, Sodium Gluconate, Citric Acid, Linalool, Geraniol, Limonene, Yeast Extract, Amino Acids, Tetrasodium Glutamate Diacetate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin